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Rpl8 ribosomal protein L8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 26962, updated on 2-May-2024

Summary

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Symbol
Rpl8provided by RGD
Full Name
ribosomal protein L8provided by RGD
Primary source
RGD:619827
See related
Ensembl:ENSRNOG00000068956 AllianceGenome:RGD:619827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables 5.8S rRNA binding activity. Involved in cellular response to nerve growth factor stimulus. Part of cytosolic large ribosomal subunit. Orthologous to human RPL8 (ribosomal protein L8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 3946.9), Thymus (RPKM 3303.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rpl8 in Genome Data Viewer
Location:
7q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (110506815..110509106)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (108626194..108628485)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (117967608..117969886)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5 Neighboring gene zinc finger protein 647 Neighboring gene Zinc finger protein 16 like, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The primary structure of rat ribosomal protein L8. Chan YL, et al. Biochem Biophys Res Commun, 1992 Jun 15. PMID 1610349
  2. Nerve growth factor selectively regulates expression of transcripts encoding ribosomal proteins. Angelastro JM, et al. BMC Neurosci, 2002. PMID 11922865, Free PMC Article
  3. Characterization by cDNA cloning of the mRNA of human ribosomal protein L8. Hanes J, et al. Biochem Biophys Res Commun, 1993 Dec 30. PMID 7506540
  4. Identification by affinity chromatography of the eukaryotic ribosomal proteins that bind to 5.8 S ribosomal ribonucleic acid. Ulbrich N, et al. J Biol Chem, 1979 Sep 10. PMID 468846
  5. Comparative study of human and mouse postsynaptic proteomes finds high compositional conservation and abundance differences for key synaptic proteins. Bayés A, et al. PLoS One, 2012. PMID 23071613, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC124745, MGC156485

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 5.8S rRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to nerve growth factor stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic translation ISO
Inferred from Sequence Orthology
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL2
Names
60S ribosomal protein L8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034916.3 → NP_001030088.2  large ribosomal subunit protein uL2

    See identical proteins and their annotated locations for NP_001030088.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    A0JMZ6, P62919
    UniProtKB/TrEMBL
    A6HSE3, A6HSE4
    Conserved Domains (1) summary
    cl40667
    Location:1 → 254
    RplB; Ribosomal protein L2 [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    110506815..110509106
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62919.2 GenPept UniProtKB/Swiss-Prot:P62919

Gene LinkOut

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