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CHORDC1 cysteine and histidine rich domain containing 1 [ Homo sapiens (human) ]

Gene ID: 26973, updated on 5-Mar-2024

Summary

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Official Symbol
CHORDC1provided by HGNC
Official Full Name
cysteine and histidine rich domain containing 1provided by HGNC
Primary source
HGNC:HGNC:14525
See related
Ensembl:ENSG00000110172 MIM:604353; AllianceGenome:HGNC:14525
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CHP1
Summary
Enables Hsp90 protein binding activity. Predicted to be involved in centrosome duplication; chaperone-mediated protein folding; and regulation of cellular response to heat. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 9.0), appendix (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
11q14.3
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (90200429..90223049, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (90120509..90143130, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (89933597..89956217, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD56 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:89867735-89868438 Neighboring gene MPRA-validated peak1387 silencer Neighboring gene N-acetylated alpha-linked acidic dipeptidase 2 Neighboring gene uncharacterized LOC124902812 Neighboring gene NANOG hESC enhancer GRCh37_chr11:89961208-89961714 Neighboring gene Sharpr-MPRA regulatory region 337 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:89974290-89974542 Neighboring gene DISC1 fusion partner 1 Neighboring gene tubulin alpha pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein. Zhao F, et al. J Biol Chem, 2014 Dec 12. PMID 25342750, Free PMC Article
  2. The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis. Fusella F, et al. Nat Commun, 2017 Nov 21. PMID 29158506, Free PMC Article
  3. Mammalian CHORD-containing protein 1 is a novel heat shock protein 90-interacting protein. Wu J, et al. FEBS Lett, 2005 Jan 17. PMID 15642353
  4. Chp-1 and melusin, two CHORD containing proteins in vertebrates. Brancaccio M, et al. FEBS Lett, 2003 Sep 11. PMID 12965203
  5. A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans. Shirasu K, et al. Cell, 1999 Nov 12. PMID 10571178

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NF-kappaB activation in breast cancer cells depends on the presence of the CHORDC1 gene product Morgana.
    Title: The IKK/NF-κB signaling pathway requires Morgana to drive breast cancer metastasis.
  2. suppression of miR-26b expression up-regulates its target gene CHORDC1, which increases HBV enhancer/promoter activities and promotes viral transcription, gene expression, and replication
    Title: MicroRNA-26b inhibits hepatitis B virus transcription and replication by targeting the host factor CHORDC1 protein.
  3. morgana causes PTEN destabilization, by inhibiting ROCK activity
    Title: Morgana acts as a proto-oncogene through inhibition of a ROCK-PTEN pathway.
  4. Chp-1 and melusin can interact with cochaperones PP5 and Sgt1 and with each other in an ATP-dependent manner
    Title: Dynamic nucleotide-dependent interactions of cysteine- and histidine-rich domain (CHORD)-containing Hsp90 cochaperones Chp-1 and melusin with cochaperones PP5 and Sgt1.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.
  6. A novel ADP-dependent HSP90 interaction with the cysteine- and histidine-rich domain (CHORD)-containing protein CHORDC1, is characterized.
    Title: A proteomic investigation of ligand-dependent HSP90 complexes reveals CHORDC1 as a novel ADP-dependent HSP90-interacting protein.
  7. This paper described the cloning of a barley CHORD containing protein, but it also described the CHORD containing proteins in other species including human and characterized the CHORD domains.
    Title: A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C. elegans.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of cysteine and histidine-rich domain (CHORD) containing 1 (CHORDC1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Vpu vpu HIV-1 Vpu is identified to have a physical interaction with cysteine and histidine-rich domain containing 1 (CHORDC1; CHP1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ37289

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp90 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in centrosome duplication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cellular response to heat ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of centrosome duplication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
cysteine and histidine-rich domain-containing protein 1
Names
CHORD-containing protein 1
CHP-1
chord domain-containing protein 1
cysteine and histidine-rich domain (CHORD) containing 1
cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
morgana
protein morgana

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144073.2 → NP_001137545.1  cysteine and histidine-rich domain-containing protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) is shorter compared to isoform a.
    Source sequence(s)
    AF123249, BC072461, CB852298, CF146721, CK300454
    Consensus CDS
    CCDS44705.1
    Related
    ENSP00000401080.2, ENST00000457199.6
    Conserved Domains (2) summary
    cd06488
    Location:211 → 297
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:136 → 197
    CHORD; CHORD

  2. NM_012124.3 → NP_036256.2  cysteine and histidine-rich domain-containing protein 1 isoform a

    See identical proteins and their annotated locations for NP_036256.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK290231, BC002339, BC072461, CB852298, CK300454
    Consensus CDS
    CCDS8289.1
    UniProtKB/Swiss-Prot
    B2R6P8, Q6IN49, Q8WVL9, Q9H3D6, Q9UHD1
    Related
    ENSP00000319255.6, ENST00000320585.11
    Conserved Domains (2) summary
    cd06488
    Location:230 → 316
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:3 → 64
    CHORD; CHORD

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    90200429..90223049 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017541.3 → XP_016873030.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

    Conserved Domains (2) summary
    cd06488
    Location:116 → 202
    p23_melusin_like; p23_like domain similar to the C-terminal (tail) domain of vertebrate Melusin and related proteins. Melusin's tail domain interacts with the cytoplasmic domain of beta1-A and beta1-D isoforms of beta1 integrin, it does not bind other integrin beta ...
    pfam04968
    Location:41 → 102
    CHORD; CHORD

  2. XM_047426766.1 → XP_047282722.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

  3. XM_047426767.1 → XP_047282723.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9PPQ5
    Related
    ENSP00000436945.1, ENST00000525317.5

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_019805497.1 Reference GRCh38.p14 PATCHES

    Range
    106552..129172 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332426.1 → XP_054188401.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

  2. XM_054332427.1 → XP_054188402.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

  3. XM_054332428.1 → XP_054188403.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9PPQ5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    90120509..90143130 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368421.1 → XP_054224396.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

  2. XM_054368422.1 → XP_054224397.1  cysteine and histidine-rich domain-containing protein 1 isoform X1

  3. XM_054368423.1 → XP_054224398.1  cysteine and histidine-rich domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    E9PPQ5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UHD1.2 GenPept UniProtKB/Swiss-Prot:Q9UHD1

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