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Cadps calcium dependent secretion activator [ Rattus norvegicus (Norway rat) ]

Gene ID: 26989, updated on 17-Aug-2024

Summary

Symbol
Cadpsprovided by RGD
Full Name
calcium dependent secretion activatorprovided by RGD
Primary source
RGD:708573
See related
EnsemblRapid:ENSRNOG00000008570 AllianceGenome:RGD:708573
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Caps; Caps1; Caps2
Summary
Enables calcium ion binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in positive regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in glutamatergic synapse and presynapse. Is extrinsic component of neuronal dense core vesicle membrane. Orthologous to human CADPS (calcium dependent secretion activator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 424.1), Adrenal (RPKM 89.7) and 1 other tissue See more
Orthologs
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Genomic context

See Cadps in Genome Data Viewer
Location:
15p15
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (14719078..15173218)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (12289803..12742786)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (15275489..15690575)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene synaptoporin Neighboring gene uncharacterized LOC102552767 Neighboring gene ornithine decarboxylase antizyme 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Histone deacetylase 1, pseudogene 3 Neighboring gene ribosomal protein S27, pseudogene 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene Fez family zinc finger 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in catecholamine secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within catecholamine secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in dense core granule exocytosis IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
NOT acts_upstream_of_or_within exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynaptic dense core vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in presynaptic dense core vesicle exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in regulated exocytosis TAS
Traceable Author Statement
more info
PubMed 
involved_in synaptic vesicle exocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in synaptic vesicle priming IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle priming ISO
Inferred from Sequence Orthology
more info
 
involved_in vesicle organization IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within vesicle organization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extrinsic component of neuronal dense core vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
calcium-dependent secretion activator 1
Names
CAPS-1
Ca++-dependent secretion activator
Ca2+ dependent secretion activator
Ca2+-dependent activator protein
Ca<2+-dependent activator protein for secretion
calcium-dependent activator protein for secretion 1
calcium-dependent secretion activator 1-like
rCAPS

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013219.2NP_037351.2  calcium-dependent secretion activator 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/TrEMBL
    A0A8I5Y0W4, A6K086, F1LLX6
    Related
    ENSRNOP00000076873.2, ENSRNOT00000094744.2
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834925
    DUF1041; Domain of Unknown Function (DUF1041)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    14719078..15173218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039093071.2XP_038948999.1  calcium-dependent secretion activator 1 isoform X15

    UniProtKB/TrEMBL
    F1LLX6
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:887978
    DUF1041; Domain of Unknown Function (DUF1041)
  2. XM_063274046.1XP_063130116.1  calcium-dependent secretion activator 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AGZ8
    Related
    ENSRNOP00000095354.2, ENSRNOT00000099157.2
  3. XM_039093064.2XP_038948992.1  calcium-dependent secretion activator 1 isoform X9

    UniProtKB/TrEMBL
    F1LLX6
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834961
    DUF1041; Domain of Unknown Function (DUF1041)
  4. XM_063274049.1XP_063130119.1  calcium-dependent secretion activator 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AGZ8
    Related
    ENSRNOP00000092113.2, ENSRNOT00000098925.2
  5. XM_063274052.1XP_063130122.1  calcium-dependent secretion activator 1 isoform X10

    UniProtKB/TrEMBL
    F1LLX6
  6. XM_063274048.1XP_063130118.1  calcium-dependent secretion activator 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ATV6
  7. XM_039093050.2XP_038948978.1  calcium-dependent secretion activator 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A5K7, A0A8I6ATV6
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834948
    DUF1041; Domain of Unknown Function (DUF1041)
  8. XM_039093067.2XP_038948995.1  calcium-dependent secretion activator 1 isoform X11

    UniProtKB/TrEMBL
    F1LLX6
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834948
    DUF1041; Domain of Unknown Function (DUF1041)
  9. XM_039093055.2XP_038948983.1  calcium-dependent secretion activator 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AGZ8
    Related
    ENSRNOP00000093742.2, ENSRNOT00000105737.2
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834938
    DUF1041; Domain of Unknown Function (DUF1041)
  10. XM_063274050.1XP_063130120.1  calcium-dependent secretion activator 1 isoform X7

    UniProtKB/TrEMBL
    A0A8I6AGZ8
  11. XM_063274054.1XP_063130124.1  calcium-dependent secretion activator 1 isoform X12

    UniProtKB/TrEMBL
    F1LLX6
  12. XM_039093060.2XP_038948988.1  calcium-dependent secretion activator 1 isoform X6

    UniProtKB/TrEMBL
    A0A8I6AGZ8
    Conserved Domains (2) summary
    cd01234
    Location:513632
    PH_CADPS; Ca2+-dependent activator protein (also called CAPS) Pleckstrin homology (PH) domain
    pfam06292
    Location:834932
    DUF1041; Domain of Unknown Function (DUF1041)
  13. XM_063274051.1XP_063130121.1  calcium-dependent secretion activator 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AGZ8, A0A8I6AI45
  14. XM_063274055.1XP_063130125.1  calcium-dependent secretion activator 1 isoform X13

  15. XM_063274056.1XP_063130126.1  calcium-dependent secretion activator 1 isoform X14