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Gsg1l GSG1-like [ Mus musculus (house mouse) ]

Gene ID: 269994, updated on 28-Oct-2024

Summary

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Official Symbol
Gsg1lprovided by MGI
Official Full Name
GSG1-likeprovided by MGI
Primary source
MGI:MGI:2685483
See related
Ensembl:ENSMUSG00000046182 AllianceGenome:MGI:2685483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
g1l; Gm637; C230098I05Rik; G630023A01Rik
Summary
Involved in regulation of postsynaptic neurotransmitter receptor internalization. Located in asymmetric synapse. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in brain; chondrocranium; and neural tube. Orthologous to human GSG1L (GSG1 like). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in adrenal adult (RPKM 69.5), cortex adult (RPKM 12.4) and 7 other tissues See more
Orthologs
human all
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Genomic context

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See Gsg1l in Genome Data Viewer
Location:
7 F3; 7 69.01 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (125477584..125681929, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (125878412..126082757, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene general transcription factor III C 1 Neighboring gene STARR-positive B cell enhancer ABC_E2848 Neighboring gene katanin interacting protein Neighboring gene VISTA enhancer mm174 Neighboring gene STARR-seq mESC enhancer starr_20126 Neighboring gene predicted gene, 51456 Neighboring gene STARR-seq mESC enhancer starr_20127 Neighboring gene exportin 6 Neighboring gene STARR-seq mESC enhancer starr_20131 Neighboring gene LAG1 homolog, ceramide synthase 2 pseudogene Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility. Kamalova A, et al. Cell Rep, 2020 Jul 21. PMID 32697982, Free PMC Article
  2. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons. Gu X, et al. Nat Commun, 2016 Mar 2. PMID 26932439, Free PMC Article
  3. In vivo neuronal subtype-specific targets of Atoh1 (Math1) in dorsal spinal cord. Lai HC, et al. J Neurosci, 2011 Jul 27. PMID 21795538, Free PMC Article
  4. TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons. Caubit X, et al. Nat Genet, 2016 Nov. PMID 27668656, Free PMC Article
  5. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes. Schwenk J, et al. Neuron, 2012 May 24. PMID 22632720

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
    Title: AMPA Receptor Auxiliary Subunit GSG1L Suppresses Short-Term Facilitation in Corticothalamic Synapses and Determines Seizure Susceptibility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (1)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of AMPA receptor activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of AMPA receptor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in Schaffer collateral - CA1 synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in asymmetric synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
germ cell-specific gene 1-like protein
Names
GSG1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101488.2 → NP_001094958.1  germ cell-specific gene 1-like protein isoform 1

    See identical proteins and their annotated locations for NP_001094958.1

    Status: VALIDATED

    Source sequence(s)
    AC012297, AC150648
    Consensus CDS
    CCDS52395.1
    UniProtKB/Swiss-Prot
    D3Z7H4
    Related
    ENSMUSP00000073591.6, ENSMUST00000073935.7
    Conserved Domains (2) summary
    pfam07803
    Location:24 → 122
    GSG-1; GSG1-like protein
    cl21598
    Location:92 → 225
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. NM_001358885.2 → NP_001345814.1  germ cell-specific gene 1-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC012297, AC150648
    Conserved Domains (1) summary
    pfam07803
    Location:24 → 122
    GSG-1; GSG1-like protein

  3. NM_001419659.1 → NP_001406588.1  germ cell-specific gene 1-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC012297, AC150648

  4. NM_001419660.1 → NP_001406589.1  germ cell-specific gene 1-like protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC012297, AC150648

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    125477584..125681929 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242625.1 → XP_030098485.1  germ cell-specific gene 1-like protein isoform X1

  2. XM_030242626.1 → XP_030098486.1  germ cell-specific gene 1-like protein isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3Z7H4.2 GenPept UniProtKB/Swiss-Prot:D3Z7H4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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