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Letm2 leucine zipper-EF-hand containing transmembrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 270035, updated on 4-Nov-2024

Summary

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Official Symbol
Letm2provided by MGI
Official Full Name
leucine zipper-EF-hand containing transmembrane protein 2provided by MGI
Primary source
MGI:MGI:2444979
See related
Ensembl:ENSMUSG00000037363 AllianceGenome:MGI:2444979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6030453H13; D030041N04Rik
Summary
Predicted to enable transmembrane transporter activity. Predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human LETM2 (leucine zipper and EF-hand containing transmembrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 17.6), cerebellum adult (RPKM 2.3) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Letm2 in Genome Data Viewer
Location:
8 A2; 8 14.17 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (26068494..26088005, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (25578478..25597989, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31288 Neighboring gene fibroblast growth factor receptor 1 Neighboring gene VISTA enhancer mm612 Neighboring gene STARR-seq mESC enhancer starr_20978 Neighboring gene predicted gene 16159 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26686963-26687146 Neighboring gene STARR-positive B cell enhancer ABC_E8232 Neighboring gene STARR-positive B cell enhancer ABC_E2860 Neighboring gene STARR-positive B cell enhancer ABC_E6630 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26722454-26722679 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26728550-26728737 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene predicted gene, 24992 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:26830817-26831000 Neighboring gene phospholipid phosphatase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mitochondrial calcium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
LETM1 domain-containing protein LETM2, mitochondrial
Names
LETM1 and EF-hand domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364069.1 → NP_001350998.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AW048776, BC055685, BE648035, DV647889
    Consensus CDS
    CCDS52527.1
    UniProtKB/Swiss-Prot
    Q7TNU7
    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  2. NM_001364070.1 → NP_001350999.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156990, AW048776, BC055685, BE648035
    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  3. NM_001364071.1 → NP_001351000.1  LETM1 domain-containing protein LETM2, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156990, AW048776, BC055685, BE648035, CJ087333
    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  4. NM_173012.3 → NP_766600.2  LETM1 domain-containing protein LETM2, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_766600.2

    Status: VALIDATED

    Source sequence(s)
    AW048776, BC055685, BE648035
    Consensus CDS
    CCDS52527.1
    UniProtKB/Swiss-Prot
    Q7TNU7
    Related
    ENSMUSP00000078160.7, ENSMUST00000079160.8
    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

RNA

  1. NR_157064.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC156990, AC160526, AW048776, BC055685, BE648035

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    26068494..26088005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154069.1 → XP_036009962.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  2. XM_036154074.1 → XP_036009967.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  3. XM_006509130.5 → XP_006509193.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  4. XM_036154073.1 → XP_036009966.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  5. XM_030243591.2 → XP_030099451.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  6. XM_017312844.3 → XP_017168333.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  7. XM_036154072.1 → XP_036009965.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X6

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

  8. XM_036154068.1 → XP_036009961.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  9. XM_006509124.5 → XP_006509187.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509187.1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  10. XM_036154067.1 → XP_036009960.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  11. XM_030243592.2 → XP_030099452.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X7

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 204
    LETM1; LETM1-like protein

  12. XM_006509126.4 → XP_006509189.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509189.1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  13. XM_006509125.4 → XP_006509188.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509188.1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  14. XM_036154070.1 → XP_036009963.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 343
    LETM1; LETM1-like protein

  15. XM_030243590.2 → XP_030099450.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X4

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 343
    LETM1; LETM1-like protein

  16. XM_006509123.5 → XP_006509186.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X1

    See identical proteins and their annotated locations for XP_006509186.1

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  17. XM_036154071.1 → XP_036009964.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X5

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  18. XM_011242140.4 → XP_011240442.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X9

    See identical proteins and their annotated locations for XP_011240442.1

    Conserved Domains (2) summary
    TIGR04526
    Location:170 → 243
    predic_Ig_block; putative immunoglobulin-blocking virulence protein
    pfam07766
    Location:3 → 163
    LETM1; LETM1-like protein

  19. XM_030243594.2 → XP_030099454.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X10

    Conserved Domains (1) summary
    pfam07766
    Location:3 → 163
    LETM1; LETM1-like protein

  20. XM_006509128.5 → XP_006509191.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X3

    Conserved Domains (1) summary
    pfam07766
    Location:120 → 343
    LETM1; LETM1-like protein

  21. XM_006509127.4 → XP_006509190.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_006509190.1

    UniProtKB/Swiss-Prot
    Q7TNU7
    Conserved Domains (1) summary
    pfam07766
    Location:120 → 383
    LETM1; LETM1-like protein

  22. XM_030243593.1 → XP_030099453.1  LETM1 domain-containing protein LETM2, mitochondrial isoform X8

    Conserved Domains (1) summary
    pfam07766
    Location:2 → 219
    LETM1; LETM1-like protein

RNA

  1. XR_870217.4 RNA Sequence

  2. XR_003947290.2 RNA Sequence

  3. XR_003947291.2 RNA Sequence

  4. XR_004934835.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNU7.1 GenPept UniProtKB/Swiss-Prot:Q7TNU7

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