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TPK1 thiamin pyrophosphokinase 1 [ Homo sapiens (human) ]

Gene ID: 27010, updated on 3-Apr-2024

Summary

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Official Symbol
TPK1provided by HGNC
Official Full Name
thiamin pyrophosphokinase 1provided by HGNC
Primary source
HGNC:HGNC:17358
See related
Ensembl:ENSG00000196511 MIM:606370; AllianceGenome:HGNC:17358
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP20; HTPK1; THMD5
Summary
The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]
Expression
Ubiquitous expression in duodenum (RPKM 1.3), testis (RPKM 0.7) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
7q35
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144451941..144836437, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145632112..146017232, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (144149034..144533146, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 40, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 83 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144172657-144173158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18729 Neighboring gene Sharpr-MPRA regulatory region 13519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18730 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:144231635-144232508 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144262663-144263224 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144316313-144316842 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26797 Neighboring gene RN7SK pseudogene 174 Neighboring gene MPRA-validated peak6812 silencer Neighboring gene uncharacterized LOC105375552

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype. Au LWC, et al. Clin Neurol Neurosurg, 2020 Dec. PMID 33031988
  2. Whole Exome Sequencing Identifies a Novel Mutation of TPK1 in a Chinese Family with Recurrent Ataxia. Zhu B, et al. J Mol Neurosci, 2020 Aug. PMID 32361878
  3. TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer. Hong JY, et al. Pathol Res Pract, 2020 Mar. PMID 31964553
  4. Reduced thiamine binding is a novel mechanism for TPK deficiency disorder. Huang W, et al. Mol Genet Genomics, 2019 Apr. PMID 30483896
  5. TPK1 mutation induced childhood onset idiopathic generalized dystonia: Report of a rare mutation and effect of deep brain stimulation. Mahajan A, et al. J Neurol Sci, 2017 May 15. PMID 28431625

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
    Title: The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
  2. Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype.
    Title: Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype.
  3. Whole Exome Sequencing Identifies a Novel Mutation of TPK1 in a Chinese Family with Recurrent Ataxia.
    Title: Whole Exome Sequencing Identifies a Novel Mutation of TPK1 in a Chinese Family with Recurrent Ataxia.
  4. TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer.
    Title: TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer.
  5. any disease mutants are directly or indirectly involved in thiamine binding. Thus, our study provided a novel rationale for thiamine supplementation, so far the major therapeutic intervention in TPK deficiency.
    Title: Reduced thiamine binding is a novel mechanism for TPK deficiency disorder.
  6. These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines.
    Title: Up-regulation of vitamin B1 homeostasis genes in breast cancer.
  7. Mutation analysis of TPK1 uncovered three missense, one splice-site, and one frameshift mutation resulting in decreased TPK protein levels
    Title: Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight.
  10. Genomic variations in either the fetal or maternal TPK1 gene could contribute to variability of birth weight in normal humans.
    Title: Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Childhood encephalopathy due to thiamine pyrophosphokinase deficiency
MedGen: C3280866 OMIM: 614458 GeneReviews: Not available
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Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of thiamin pyrophosphokinase 1 (TPK1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif upregulates the expression of thiamin pyrophosphokinase 1 (TPK1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables thiamine binding IEA
Inferred from Electronic Annotation
more info
  
enables thiamine diphosphokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine diphosphokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine diphosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thiamine diphosphate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in thiamine diphosphate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in thiamine metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
thiamin pyrophosphokinase 1
Names
placental protein 20
thiamine diphosphokinase
thiamine kinase
NP_001035947.1
NP_001337808.1
NP_001337809.1
NP_001337810.1
NP_001337811.1
NP_001337812.1
NP_001337813.1
NP_001337814.1
NP_001337815.1
NP_001337816.1
NP_001337818.1
NP_001337822.1
NP_001337823.1
NP_001337824.1
NP_071890.2
XP_005250027.1
XP_011514333.1
XP_011514334.1
XP_011514335.1
XP_011514336.1
XP_011514339.1
XP_011514341.1
XP_011514342.1
XP_011514345.1
XP_011514348.1
XP_011514349.1
XP_011514350.1
XP_016867458.1
XP_016867459.1
XP_016867460.1
XP_016867461.1
XP_016867469.1
XP_016867470.1
XP_024302485.1
XP_047276148.1
XP_047276150.1
XP_047276151.1
XP_047276152.1
XP_047276153.1
XP_047276154.1
XP_047276155.1
XP_054213854.1
XP_054213855.1
XP_054213856.1
XP_054213857.1
XP_054213858.1
XP_054213859.1
XP_054213860.1
XP_054213861.1
XP_054213862.1
XP_054213863.1
XP_054213864.1
XP_054213865.1
XP_054213866.1
XP_054213867.1
XP_054213868.1
XP_054213869.1
XP_054213870.1
XP_054213871.1
XP_054213872.1
XP_054213873.1
XP_054213874.1
XP_054213875.1
XP_054213876.1
XP_054213877.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032112.2 RefSeqGene

    Range
    5001..389113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001042482.2 → NP_001035947.1  thiamin pyrophosphokinase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC004534, BC040555, BI770816, BX446289, DA135998
    Consensus CDS
    CCDS55178.1
    UniProtKB/TrEMBL
    F5GZG6
    Related
    ENSP00000367339.3, ENST00000378099.7
    Conserved Domains (1) summary
    cl27179
    Location:21 → 192
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  2. NM_001350879.1 → NP_001337808.1  thiamin pyrophosphokinase 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), as well as variant 1, encodes the longest isoform (a).
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Consensus CDS
    CCDS5888.1
    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0
    Conserved Domains (1) summary
    PLN02714
    Location:21 → 241
    PLN02714; thiamin pyrophosphokinase

  3. NM_001350880.1 → NP_001337809.1  thiamin pyrophosphokinase 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), as well as variant 2, encodes isoform b. Variants 2 and 4 both encode the same isoform (b).
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Consensus CDS
    CCDS55178.1
    UniProtKB/TrEMBL
    F5GZG6
    Conserved Domains (1) summary
    cl27179
    Location:21 → 192
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  4. NM_001350881.1 → NP_001337810.1  thiamin pyrophosphokinase 1 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    cl27179
    Location:21 → 204
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  5. NM_001350882.1 → NP_001337811.1  thiamin pyrophosphokinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform d.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    cl27179
    Location:58 → 236
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  6. NM_001350883.1 → NP_001337812.1  thiamin pyrophosphokinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform d.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    cl27179
    Location:58 → 236
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  7. NM_001350884.2 → NP_001337813.1  thiamin pyrophosphokinase 1 isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform d.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864
    Conserved Domains (1) summary
    cl27179
    Location:58 → 236
    TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

  8. NM_001350885.1 → NP_001337814.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variants 10, 11, 12, 13, and 14, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  9. NM_001350886.1 → NP_001337815.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variants 9, 11, 12, 13, and 14, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  10. NM_001350887.1 → NP_001337816.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variants 9, 10, 12, 13, and 14, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  11. NM_001350889.1 → NP_001337818.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 9, 10, 11, 13, and 14, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  12. NM_001350893.1 → NP_001337822.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 9, 10, 11, 12, and 14, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  13. NM_001350894.1 → NP_001337823.1  thiamin pyrophosphokinase 1 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 9, 10, 11, 12, and 13, encodes isoform e.
    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  14. NM_001350895.1 → NP_001337824.1  thiamin pyrophosphokinase 1 isoform f

    Status: REVIEWED

    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384
    UniProtKB/TrEMBL
    B3KRJ6
    Conserved Domains (1) summary
    PLN02714
    Location:5 → 124
    PLN02714; thiamin pyrophosphokinase

  15. NM_022445.4 → NP_071890.2  thiamin pyrophosphokinase 1 isoform a

    See identical proteins and their annotated locations for NP_071890.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
    Source sequence(s)
    AF297710, BC040555, DA135998
    Consensus CDS
    CCDS5888.1
    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0
    Related
    ENSP00000353165.3, ENST00000360057.7
    Conserved Domains (1) summary
    PLN02714
    Location:21 → 241
    PLN02714; thiamin pyrophosphokinase

RNA

  1. NR_146934.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384

  2. NR_146935.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864, AC074384

  3. NR_146936.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC004534, AC004743, AC004833, AC004864
    Related
    ENST00000482940.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    144451941..144836437 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249970.2 → XP_005250027.1  thiamin pyrophosphokinase 1 isoform X1

    See identical proteins and their annotated locations for XP_005250027.1

    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0
    Conserved Domains (1) summary
    PLN02714
    Location:21 → 241
    PLN02714; thiamin pyrophosphokinase

  2. XM_047420194.1 → XP_047276150.1  thiamin pyrophosphokinase 1 isoform X2

    UniProtKB/TrEMBL
    F5GZG6

  3. XM_011516033.3 → XP_011514335.1  thiamin pyrophosphokinase 1 isoform X6

    See identical proteins and their annotated locations for XP_011514335.1

    Conserved Domains (2) summary
    cd07995
    Location:20 → 265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 267
    PLN02714; thiamin pyrophosphokinase

  4. XM_047420195.1 → XP_047276151.1  thiamin pyrophosphokinase 1 isoform X2

    UniProtKB/TrEMBL
    F5GZG6

  5. XM_047420192.1 → XP_047276148.1  thiamin pyrophosphokinase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0

  6. XM_047420199.1 → XP_047276155.1  thiamin pyrophosphokinase 1 isoform X5

  7. XM_011516034.3 → XP_011514336.1  thiamin pyrophosphokinase 1 isoform X6

    See identical proteins and their annotated locations for XP_011514336.1

    Conserved Domains (2) summary
    cd07995
    Location:20 → 265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 267
    PLN02714; thiamin pyrophosphokinase

  8. XM_047420197.1 → XP_047276153.1  thiamin pyrophosphokinase 1 isoform X5

  9. XM_011516043.2 → XP_011514345.1  thiamin pyrophosphokinase 1 isoform X12

    Conserved Domains (2) summary
    cd07995
    Location:20 → 216
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 218
    PLN02714; thiamin pyrophosphokinase

  10. XM_011516031.2 → XP_011514333.1  thiamin pyrophosphokinase 1 isoform X6

    See identical proteins and their annotated locations for XP_011514333.1

    Conserved Domains (2) summary
    cd07995
    Location:20 → 265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 267
    PLN02714; thiamin pyrophosphokinase

  11. XM_011516032.3 → XP_011514334.1  thiamin pyrophosphokinase 1 isoform X6

    See identical proteins and their annotated locations for XP_011514334.1

    Conserved Domains (2) summary
    cd07995
    Location:20 → 265
    TPK; Thiamine pyrophosphokinase
    PLN02714
    Location:21 → 267
    PLN02714; thiamin pyrophosphokinase

  12. XM_047420198.1 → XP_047276154.1  thiamin pyrophosphokinase 1 isoform X5

  13. XM_024446717.2 → XP_024302485.1  thiamin pyrophosphokinase 1 isoform X5

    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  14. XM_017011970.1 → XP_016867459.1  thiamin pyrophosphokinase 1 isoform X8

    Conserved Domains (2) summary
    cd07995
    Location:58 → 260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19 → 260
    thi_PPkinase; thiamine pyrophosphokinase

  15. XM_047420196.1 → XP_047276152.1  thiamin pyrophosphokinase 1 isoform X3

    UniProtKB/TrEMBL
    Q6ZQX6
    Related
    ENSP00000438813.2, ENST00000538212.6

  16. XM_011516037.3 → XP_011514339.1  thiamin pyrophosphokinase 1 isoform X8

    See identical proteins and their annotated locations for XP_011514339.1

    Conserved Domains (2) summary
    cd07995
    Location:58 → 260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19 → 260
    thi_PPkinase; thiamine pyrophosphokinase

  17. XM_011516039.3 → XP_011514341.1  thiamin pyrophosphokinase 1 isoform X10

    Conserved Domains (1) summary
    cd07995
    Location:33 → 239
    TPK; Thiamine pyrophosphokinase

  18. XM_017011971.2 → XP_016867460.1  thiamin pyrophosphokinase 1 isoform X8

    Conserved Domains (2) summary
    cd07995
    Location:58 → 260
    TPK; Thiamine pyrophosphokinase
    TIGR01378
    Location:19 → 260
    thi_PPkinase; thiamine pyrophosphokinase

  19. XM_011516047.3 → XP_011514349.1  thiamin pyrophosphokinase 1 isoform X5

    See identical proteins and their annotated locations for XP_011514349.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  20. XM_011516048.1 → XP_011514350.1  thiamin pyrophosphokinase 1 isoform X5

    See identical proteins and their annotated locations for XP_011514350.1

    UniProtKB/Swiss-Prot
    Q9H3S4
    Conserved Domains (1) summary
    PLN02714
    Location:16 → 135
    PLN02714; thiamin pyrophosphokinase

  21. XM_017011980.3 → XP_016867469.1  thiamin pyrophosphokinase 1 isoform X4

    Conserved Domains (1) summary
    cd07995
    Location:2 → 159
    TPK; Thiamine pyrophosphokinase

  22. XM_017011981.3 → XP_016867470.1  thiamin pyrophosphokinase 1 isoform X4

    Conserved Domains (1) summary
    cd07995
    Location:2 → 159
    TPK; Thiamine pyrophosphokinase

  23. XM_017011972.2 → XP_016867461.1  thiamin pyrophosphokinase 1 isoform X9

  24. XM_017011969.2 → XP_016867458.1  thiamin pyrophosphokinase 1 isoform X7

  25. XM_011516040.3 → XP_011514342.1  thiamin pyrophosphokinase 1 isoform X11

    Conserved Domains (1) summary
    cd07995
    Location:20 → 230
    TPK; Thiamine pyrophosphokinase

  26. XM_011516046.2 → XP_011514348.1  thiamin pyrophosphokinase 1 isoform X13

    UniProtKB/TrEMBL
    F8WCM7
    Related
    ENSP00000367338.4, ENST00000378098.8
    Conserved Domains (1) summary
    pfam04263
    Location:30 → 137
    TPK_catalytic; Thiamin pyrophosphokinase, catalytic domain

RNA

  1. XR_001744630.2 RNA Sequence

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654715.1 Reference GRCh38.p14 PATCHES

    Range
    501398..674070 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    145632112..146017232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357886.1 → XP_054213861.1  thiamin pyrophosphokinase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0

  2. XM_054357892.1 → XP_054213867.1  thiamin pyrophosphokinase 1 isoform X2

    UniProtKB/TrEMBL
    F5GZG6

  3. XM_054357890.1 → XP_054213865.1  thiamin pyrophosphokinase 1 isoform X18

  4. XM_054357891.1 → XP_054213866.1  thiamin pyrophosphokinase 1 isoform X19

  5. XM_054357879.1 → XP_054213854.1  thiamin pyrophosphokinase 1 isoform X14

  6. XM_054357893.1 → XP_054213868.1  thiamin pyrophosphokinase 1 isoform X2

    UniProtKB/TrEMBL
    F5GZG6

  7. XM_054357887.1 → XP_054213862.1  thiamin pyrophosphokinase 1 isoform X1

    UniProtKB/Swiss-Prot
    A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
    UniProtKB/TrEMBL
    A0A090N8Y0

  8. XM_054357898.1 → XP_054213873.1  thiamin pyrophosphokinase 1 isoform X5

  9. XM_054357880.1 → XP_054213855.1  thiamin pyrophosphokinase 1 isoform X14

  10. XM_054357899.1 → XP_054213874.1  thiamin pyrophosphokinase 1 isoform X5

  11. XM_054357881.1 → XP_054213856.1  thiamin pyrophosphokinase 1 isoform X14

  12. XM_054357882.1 → XP_054213857.1  thiamin pyrophosphokinase 1 isoform X14

  13. XM_054357897.1 → XP_054213872.1  thiamin pyrophosphokinase 1 isoform X5

  14. XM_054357902.1 → XP_054213877.1  thiamin pyrophosphokinase 1 isoform X5

  15. XM_054357883.1 → XP_054213858.1  thiamin pyrophosphokinase 1 isoform X15

  16. XM_054357894.1 → XP_054213869.1  thiamin pyrophosphokinase 1 isoform X3

    UniProtKB/TrEMBL
    Q6ZQX6

  17. XM_054357884.1 → XP_054213859.1  thiamin pyrophosphokinase 1 isoform X15

  18. XM_054357888.1 → XP_054213863.1  thiamin pyrophosphokinase 1 isoform X16

  19. XM_054357885.1 → XP_054213860.1  thiamin pyrophosphokinase 1 isoform X15

  20. XM_054357900.1 → XP_054213875.1  thiamin pyrophosphokinase 1 isoform X5

  21. XM_054357901.1 → XP_054213876.1  thiamin pyrophosphokinase 1 isoform X5

  22. XM_054357895.1 → XP_054213870.1  thiamin pyrophosphokinase 1 isoform X4

  23. XM_054357889.1 → XP_054213864.1  thiamin pyrophosphokinase 1 isoform X17

  24. XM_054357896.1 → XP_054213871.1  thiamin pyrophosphokinase 1 isoform X20

RNA

  1. XR_008487563.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H3S4.1 GenPept UniProtKB/Swiss-Prot:Q9H3S4

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