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Etv3 ets variant 3 [ Mus musculus (house mouse) ]

Gene ID: 27049, updated on 2-Nov-2024

Summary

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Official Symbol
Etv3provided by MGI
Official Full Name
ets variant 3provided by MGI
Primary source
MGI:MGI:1350926
See related
Ensembl:ENSMUSG00000003382 AllianceGenome:MGI:1350926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pe1; METS
Summary
Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cellular response to granulocyte macrophage colony-stimulating factor stimulus; negative regulation of cell population proliferation; and negative regulation of transcription by RNA polymerase II. Located in chromatin. Part of RNA polymerase II transcription repressor complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; retina; and thymus primordium. Orthologous to human ETV3 (ETS variant transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 11.5), mammary gland adult (RPKM 9.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Etv3 in Genome Data Viewer
Location:
3 F1; 3 38.19 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87432891..87447463)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87525577..87540158)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 40084 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87239522-87239823 Neighboring gene Fc receptor-like 5 Neighboring gene STARR-seq mESC enhancer starr_08157 Neighboring gene STARR-seq mESC enhancer starr_08158 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87291959-87292260 Neighboring gene predicted gene, 40085 Neighboring gene STARR-positive B cell enhancer ABC_E7919 Neighboring gene STARR-positive B cell enhancer mm9_chr3:87310398-87310698 Neighboring gene STARR-positive B cell enhancer ABC_E7920 Neighboring gene STARR-positive B cell enhancer ABC_E6067 Neighboring gene STARR-positive B cell enhancer ABC_E10189 Neighboring gene STARR-positive B cell enhancer ABC_E6068 Neighboring gene ets variant 3-like Neighboring gene predicted gene, 25167

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The ets gene family. Macleod K, et al. Trends Biochem Sci, 1992 Jul. PMID 1502727
  2. The ETS family of oncogenic transcription factors in solid tumours. Sizemore GM, et al. Nat Rev Cancer, 2017 Jun. PMID 28450705
  3. PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23. Klemsz M, et al. Genomics, 1994 Mar 15. PMID 8020980
  4. Ets domain transcription factor PE1 suppresses human interstitial collagenase promoter activity by antagonizing protein-DNA interactions at a critical AP1 element. Bidder M, et al. Biochemistry, 2000 Aug 1. PMID 10913304
  5. Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3. Carlson SM, et al. Sci Signal, 2011 Oct 25. PMID 22028470, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that ETV3 (a member of the E twenty-six family of transcriptional regulators), was extensively phosphorylated on sites within canonical and noncanonical ERK motifs.
    Title: Large-scale discovery of ERK2 substrates identifies ERK-mediated transcriptional regulation by ETV3.
  2. The ETV3 expression was strongly induced by the STAT3 pathway regulated by IL-10 but not by STAT3 signaling activated by IL-6, which cannot activate the anti-inflammatory signaling pathway.
    Title: Cutting edge: A transcriptional repressor and corepressor induced by the STAT3-regulated anti-inflammatory signaling pathway.
  3. ETS gene expression is an essential requirement for normal sensory neuron differentiation
    Title: A developmental switch in the response of DRG neurons to ETS transcription factor signaling.
  4. PE-1/METS is an antiproliferative Ets repressor factor induced by CREB-1/CREM-1 during macrophage differentiation
    Title: PE-1/METS, an antiproliferative Ets repressor factor, is induced by CREB-1/CREM-1 during macrophage differentiation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DEAD/H-box RNA helicase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription repressor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ETS translocation variant 3
Names
ETS domain transcriptional repressor PE1
ETS-domain protein
ets variant gene 3
mitogenic Ets transcriptional suppressor METS

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083318.3 → NP_001076787.1  ETS translocation variant 3 isoform 1

    See identical proteins and their annotated locations for NP_001076787.1

    Status: VALIDATED

    Source sequence(s)
    AC139241
    Consensus CDS
    CCDS17453.1
    UniProtKB/Swiss-Prot
    G5E907, Q8R4Z4, Q9QZW1
    UniProtKB/TrEMBL
    Q3U1H6
    Related
    ENSMUSP00000127419.2, ENSMUST00000170036.8
    Conserved Domains (1) summary
    smart00413
    Location:34 → 120
    ETS; erythroblast transformation specific domain

  2. NM_001286844.2 → NP_001273773.1  ETS translocation variant 3 isoform 1

    See identical proteins and their annotated locations for NP_001273773.1

    Status: VALIDATED

    Source sequence(s)
    AC139241
    Consensus CDS
    CCDS17453.1
    UniProtKB/Swiss-Prot
    G5E907, Q8R4Z4, Q9QZW1
    UniProtKB/TrEMBL
    Q3U1H6
    Conserved Domains (1) summary
    smart00413
    Location:34 → 120
    ETS; erythroblast transformation specific domain

  3. NM_001359750.2 → NP_001346679.1  ETS translocation variant 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139241
    Conserved Domains (1) summary
    smart00413
    Location:34 → 120
    ETS; erythroblast transformation specific domain

  4. NM_001411078.1 → NP_001398007.1  ETS translocation variant 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC139241

  5. NM_001411079.1 → NP_001398008.1  ETS translocation variant 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139241
    UniProtKB/TrEMBL
    D3YVU8
    Related
    ENSMUSP00000114047.2, ENSMUST00000117293.2

  6. NM_001411080.1 → NP_001398009.1  ETS translocation variant 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC139241
    UniProtKB/TrEMBL
    D3YVU8

  7. NM_012051.5 → NP_036181.3  ETS translocation variant 3 isoform 1

    See identical proteins and their annotated locations for NP_036181.3

    Status: VALIDATED

    Source sequence(s)
    AC139241
    Consensus CDS
    CCDS17453.1
    UniProtKB/Swiss-Prot
    G5E907, Q8R4Z4, Q9QZW1
    UniProtKB/TrEMBL
    Q3U1H6
    Related
    ENSMUSP00000112915.2, ENSMUST00000119109.8
    Conserved Domains (1) summary
    smart00413
    Location:34 → 120
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    87432891..87447463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R4Z4.2 GenPept UniProtKB/Swiss-Prot:Q8R4Z4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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