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Taf1 TATA-box binding protein associated factor 1 [ Mus musculus (house mouse) ]

Gene ID: 270627, updated on 28-Oct-2024

Summary

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Official Symbol
Taf1provided by MGI
Official Full Name
TATA-box binding protein associated factor 1provided by MGI
Primary source
MGI:MGI:1336878
See related
Ensembl:ENSMUSG00000031314 AllianceGenome:MGI:1336878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ccg1; KAT4; p250; Ccg-1; Taf2a; N-TAF1; TAFII250; B430306D02Rik
Summary
Enables DNA binding activity; histone acetyltransferase activity; and promoter-specific chromatin binding activity. Predicted to be involved in RNA polymerase II preinitiation complex assembly; mRNA transcription by RNA polymerase II; and positive regulation of transcription initiation by RNA polymerase II. Located in pronucleus. Is expressed in several structures, including branchial arch; central nervous system; genitourinary system; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1 (TATA-box binding protein associated factor 1). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Broad expression in CNS E11.5 (RPKM 8.6), CNS E14 (RPKM 5.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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See Taf1 in Genome Data Viewer
Location:
X D; X 44.29 cM
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (100576335..100644635)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (101527572..101601789)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47650 Neighboring gene anaphase promoting complex subunit 13 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2537 Neighboring gene ring finger protein 26 pseudogene Neighboring gene STARR-seq mESC enhancer starr_47657 Neighboring gene O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Neighboring gene STARR-seq mESC enhancer starr_47659 Neighboring gene RNA binding protein pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Taf1 knockout is lethal in embryonic male mice and heterozygous females show weight and movement disorders. Crombie EM, et al. Dis Model Mech, 2024 Jul 1. PMID 38804708, Free PMC Article
  2. Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice. Jambaldorj J, et al. Biochem Biophys Res Commun, 2012 Aug 24. PMID 22842574
  3. TAFII250, Egr-1, and D-type cyclin expression in mice and neonatal rat cardiomyocytes treated with doxorubicin. Saadane N, et al. Am J Physiol, 1999 Mar. PMID 10070062
  4. Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms. Cirnaru MD, et al. Mov Disord, 2021 Dec. PMID 34403156
  5. TAF7: a possible transcription initiation check-point regulator. Gegonne A, et al. Proc Natl Acad Sci U S A, 2006 Jan 17. PMID 16407123, Free PMC Article

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
    Title: Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
  2. these result suggests that the N-Taf1 gene has an important role in non-dividing neuronal cell rather than in cell division and proliferation during neurogenesis.
    Title: Sustained expression of a neuron-specific isoform of the Taf1 gene in development stages and aging in mice.
  3. Data show that Taf1 is decreased at the osteogenic initiation stage in the maxilla of Tgfbr2 mutant mice.
    Title: Transforming growth factor-beta regulates basal transcriptional regulatory machinery to control cell proliferation and differentiation in cranial neural crest-derived osteoprogenitor cells.
  4. Appears in pronuclei 6 h post-fertilization and reached a relatively high level before zygotic genome activation.
    Title: Regulated expression of TAF1 in 1-cell mouse embryos.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to H3K27me3 modified histone binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase I general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II general transcription initiation factor activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II general transcription initiation factor activity ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II general transcription initiation factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables TBP-class protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables TBP-class protein binding IEA
Inferred from Electronic Annotation
more info
  
enables TBP-class protein binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone acetyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone acetyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription regulator inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin conjugating enzyme activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA polymerase II preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of MLL1 complex ISO
Inferred from Sequence Orthology
more info
  
part_of MLL1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in chromatin ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with nucleolus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of transcription factor TFIID complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 1
Names
TBP-associated factor 250 kDa
cell cycle gene 1 protein
cell cycle, G1 phase defect
transcription initiation factor TFIID 250 kDa subunit
NP_001277658.2
NP_001392888.2
NP_001392889.2
NP_001392890.2
NP_001392891.2
XP_006528114.1
XP_017174001.1
XP_017174002.1
XP_017174004.1
XP_017174005.1
XP_017174007.1
XP_036017866.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290729.3 → NP_001277658.2  transcription initiation factor TFIID subunit 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    Consensus CDS
    CCDS85793.1
    Related
    ENSMUSP00000114765.3, ENSMUST00000149274.9

  2. NM_001405959.2 → NP_001392888.2  transcription initiation factor TFIID subunit 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    Related
    ENSMUSP00000138159.2, ENSMUST00000143908.8

  3. NM_001405960.2 → NP_001392889.2  transcription initiation factor TFIID subunit 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722
    UniProtKB/TrEMBL
    A0AAQ4VMV6
    Related
    ENSMUSP00000160012.1, ENSMUST00000249914.1

  4. NM_001405961.2 → NP_001392890.2  transcription initiation factor TFIID subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722

  5. NM_001405962.2 → NP_001392891.2  transcription initiation factor TFIID subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL806534, AL831722

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    100576335..100644635
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161973.1 → XP_036017866.1  transcription initiation factor TFIID subunit 1 isoform X9

    UniProtKB/TrEMBL
    S4R1B9
    Conserved Domains (4) summary
    cd05511
    Location:1533 → 1645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle

  2. XM_017318518.3 → XP_017174007.1  transcription initiation factor TFIID subunit 1 isoform X10

    UniProtKB/TrEMBL
    S4R1B9
    Conserved Domains (5) summary
    cd05511
    Location:1411 → 1522
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle
    cl02556
    Location:1533 → 1612
    Bromodomain; Bromodomains are found in many chromatin-associated proteins and in nuclear histone acetyltransferases. They interact specifically with acetylated lysine.

  3. XM_017318512.2 → XP_017174001.1  transcription initiation factor TFIID subunit 1 isoform X1

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:1533 → 1645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle

  4. XM_017318515.3 → XP_017174004.1  transcription initiation factor TFIID subunit 1 isoform X6

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:1533 → 1645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle

  5. XM_017318513.3 → XP_017174002.1  transcription initiation factor TFIID subunit 1 isoform X2

    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Conserved Domains (4) summary
    cd05511
    Location:1533 → 1645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle

  6. XM_017318516.3 → XP_017174005.1  transcription initiation factor TFIID subunit 1 isoform X7

    UniProtKB/Swiss-Prot
    A2AM32, A2AM33, O35361, Q3UPF3, Q3V223, Q505F9, Q80UV9, Q8BQH8, Q8BQQ7, Q8BR59, Q8C7N8, Q9WTW9, Q9WTX0, Q9WTX1
    Conserved Domains (4) summary
    cd05511
    Location:1533 → 1645
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:591 → 1054
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1287 → 1322
    zf-CCHC_6; Zinc knuckle

  7. XM_006528051.4 → XP_006528114.1  transcription initiation factor TFIID subunit 1 isoform X4

    UniProtKB/TrEMBL
    A0A067XG50, B1Q2W7
    Conserved Domains (4) summary
    cd05511
    Location:1507 → 1619
    Bromo_TFIID; Bromodomain, TFIID-like subfamily. Human TAFII250 (or TAF250) is the largest subunit of TFIID, a large multi-domain complex, which initiates the assembly of the transcription machinery. TAFII250 contains two bromodomains that specifically bind to ...
    pfam09247
    Location:28 → 86
    TBP-binding; TATA box-binding protein binding
    pfam12157
    Location:565 → 1028
    DUF3591; Protein of unknown function (DUF3591)
    pfam15288
    Location:1261 → 1296
    zf-CCHC_6; Zinc knuckle

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001081008.1: Suppressed sequence

    Description
    NM_001081008.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UV9.2 GenPept UniProtKB/Swiss-Prot:Q80UV9

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