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CLUL1 clusterin like 1 [ Homo sapiens (human) ]

Gene ID: 27098, updated on 3-Apr-2024

Summary

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Official Symbol
CLUL1provided by HGNC
Official Full Name
clusterin like 1provided by HGNC
Primary source
HGNC:HGNC:2096
See related
Ensembl:ENSG00000079101 MIM:616990; AllianceGenome:HGNC:2096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RA337M
Summary
Predicted to enable misfolded protein binding activity. Predicted to be located in extracellular region. Predicted to be active in extracellular space and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in prostate (RPKM 1.3), thyroid (RPKM 0.8) and 10 other tissues See more
Orthologs
all
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Genomic context

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See CLUL1 in Genome Data Viewer
Location:
18p11.32
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (596988..650182)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (751354..804514)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (596988..650182)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 146 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:596737-596866 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:597469-597968 Neighboring gene centrin 1 Neighboring gene Sharpr-MPRA regulatory region 12053 Neighboring gene uncharacterized LOC105371952 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:641155-642354 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657377-657878 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:657879-658378 Neighboring gene TYMS opposite strand RNA Neighboring gene enolase superfamily member 1 Neighboring gene thymidylate synthetase Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr18:686134-686722 Neighboring gene ReSE screen-validated silencer GRCh37_chr18:697612-697744 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9242 Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:712826-713405 Neighboring gene Sharpr-MPRA regulatory region 6782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13022 Neighboring gene YES proto-oncogene 1, Src family tyrosine kinase Neighboring gene RNA, U1 small nuclear 109, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Comparative analysis and expression of CLUL1, a cone photoreceptor-specific gene. Zhang Q, et al. Invest Ophthalmol Vis Sci, 2003 Oct. PMID 14507903
  2. Molecular cloning, characterization and expression of a novel retinal clusterin-like protein cDNA. Zhang Q, et al. Gene, 2000 Feb 8. PMID 10675623
  3. Mapping of transcription start sites of human retina expressed genes. Roni V, et al. BMC Genomics, 2007 Feb 7. PMID 17286855, Free PMC Article
  4. RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers. Pang K, et al. Nat Commun, 2019 Dec 20. PMID 31862882, Free PMC Article
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. Bailey SD, et al. Diabetes Care, 2010 Oct. PMID 20628086, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables misfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
clusterin-like protein 1
Names
clusterin-like 1 (retinal)
retinal clusterin-like protein
retinal-specific clusterin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289036.3 → NP_001275965.2  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Related
    ENSP00000441726.2, ENST00000540035.5
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  2. NM_001318522.2 → NP_001305451.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Related
    ENSP00000464642.1, ENST00000579494.1
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  3. NM_001375492.2 → NP_001362421.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  4. NM_001393344.1 → NP_001380273.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Related
    ENSP00000510271.1, ENST00000692774.1
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  5. NM_001393345.1 → NP_001380274.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  6. NM_001393346.1 → NP_001380275.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  7. NM_001393347.1 → NP_001380276.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  8. NM_001393348.1 → NP_001380277.1  clusterin-like protein 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  9. NM_014410.6 → NP_055225.1  clusterin-like protein 1 precursor

    See identical proteins and their annotated locations for NP_055225.1

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Related
    ENSP00000383449.2, ENST00000400606.6
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

  10. NM_199167.2 → NP_954636.1  clusterin-like protein 1 precursor

    See identical proteins and their annotated locations for NP_954636.1

    Status: VALIDATED

    Source sequence(s)
    AP001178
    Consensus CDS
    CCDS42405.1
    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
    UniProtKB/TrEMBL
    J3QKW8
    Related
    ENSP00000341128.6, ENST00000338387.11
    Conserved Domains (1) summary
    pfam01093
    Location:33 → 462
    Clusterin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    596988..650182
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525651.3 → XP_011523953.1  clusterin-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011523953.1

    UniProtKB/TrEMBL
    J3QKW8
    Conserved Domains (3) summary
    smart00030
    Location:37 → 248
    CLb; CLUSTERIN Beta chain
    smart00035
    Location:249 → 471
    CLa; CLUSTERIN alpha chain
    pfam01093
    Location:44 → 473
    Clusterin; Clusterin

  2. XM_011525648.4 → XP_011523950.2  clusterin-like protein 1 isoform X1

    Related
    ENSP00000463269.2, ENST00000581619.5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    751354..804514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054318530.1 → XP_054174505.1  clusterin-like protein 1 isoform X2

  2. XM_054318526.1 → XP_054174501.1  clusterin-like protein 1 isoform X3

  3. XM_054318529.1 → XP_054174504.1  clusterin-like protein 1 isoform X4

  4. XM_054318527.1 → XP_054174502.1  clusterin-like protein 1 isoform X3

  5. XM_054318528.1 → XP_054174503.1  clusterin-like protein 1 isoform X3

  6. XM_054318531.1 → XP_054174506.1  clusterin-like protein 1 isoform X5

    UniProtKB/Swiss-Prot
    A0FDN7, Q15846
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q15846.1 GenPept UniProtKB/Swiss-Prot:Q15846

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