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GPR82 G protein-coupled receptor 82 [ Homo sapiens (human) ]

Gene ID: 27197, updated on 2-Nov-2024

Summary

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Official Symbol
GPR82provided by HGNC
Official Full Name
G protein-coupled receptor 82provided by HGNC
Primary source
HGNC:HGNC:4533
See related
Ensembl:ENSG00000171657 MIM:300748; AllianceGenome:HGNC:4533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is an orphan G protein-coupled receptor of unknown function. The encoded protein is a member of a family of proteins that contain seven transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. [provided by RefSeq, Sep 2011]
Expression
Broad expression in lymph node (RPKM 1.4), appendix (RPKM 1.3) and 18 other tissues See more
Orthologs
mouse all
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Genomic context

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See GPR82 in Genome Data Viewer
Location:
Xp11.4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (41724181..41730130)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (41129121..41135070)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (41583434..41589383)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene calcium/calmodulin dependent serine protein kinase Neighboring gene RNA, 7SL, cytoplasmic 144, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29561 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41570764-41571264 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:41571265-41571765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:41577964-41578464 Neighboring gene G protein-coupled receptor 34 Neighboring gene ribosomal protein S15a pseudogene 39 Neighboring gene NANOG hESC enhancer GRCh37_chrX:41662134-41662675 Neighboring gene RNA, U6 small nuclear 202, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Discovery and mapping of ten novel G protein-coupled receptor genes. Lee DK, et al. Gene, 2001 Sep 5. PMID 11574155
  2. A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation. Tarpey PS, et al. Nat Genet, 2009 May. PMID 19377476, Free PMC Article
  3. Identification of G protein-coupled receptor genes from the human genome sequence. Takeda S, et al. FEBS Lett, 2002 Jun 5. PMID 12044878
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 82

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016566.1 RefSeqGene

    Range
    5027..10976
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080817.5 → NP_543007.1  probable G-protein coupled receptor 82

    See identical proteins and their annotated locations for NP_543007.1

    Status: VALIDATED

    Source sequence(s)
    AL627402, BC070180
    Consensus CDS
    CCDS14259.1
    UniProtKB/Swiss-Prot
    Q5VT13, Q96P67
    Related
    ENSP00000303549.4, ENST00000302548.5
    Conserved Domains (1) summary
    pfam00001
    Location:32 → 308
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    41724181..41730130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047441991.1 → XP_047297947.1  probable G-protein coupled receptor 82 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT13, Q96P67

  2. XM_047441992.1 → XP_047297948.1  probable G-protein coupled receptor 82 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT13, Q96P67

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    41129121..41135070
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054326835.1 → XP_054182810.1  probable G-protein coupled receptor 82 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT13, Q96P67

  2. XM_054326836.1 → XP_054182811.1  probable G-protein coupled receptor 82 isoform X1

    UniProtKB/Swiss-Prot
    Q5VT13, Q96P67
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96P67.1 GenPept UniProtKB/Swiss-Prot:Q96P67

Gene LinkOut

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