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C5AR2 complement C5a receptor 2 [ Homo sapiens (human) ]

Gene ID: 27202, updated on 2-Nov-2024

Summary

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Official Symbol
C5AR2provided by HGNC
Official Full Name
complement C5a receptor 2provided by HGNC
Primary source
HGNC:HGNC:4527
See related
Ensembl:ENSG00000134830 MIM:609949; AllianceGenome:HGNC:4527
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5L2; GPF77; GPR77
Summary
This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in spleen (RPKM 2.6), appendix (RPKM 1.3) and 16 other tissues See more
Orthologs
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Genomic context

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See C5AR2 in Genome Data Viewer
Location:
19q13.32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47332175..47347329)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50157644..50172793)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47835432..47850586)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 9 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10851 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10852 Neighboring gene CRISPRi-validated cis-regulatory element chr19.5070 Neighboring gene InaF motif containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47793125-47793976 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:47818477-47818672 Neighboring gene Sharpr-MPRA regulatory region 10427 Neighboring gene complement C5a receptor 1 Neighboring gene Sharpr-MPRA regulatory region 4678 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47852412-47853316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47858319-47858818 Neighboring gene DExH-box helicase 34 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47895565-47896211 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr19:47896212-47896859 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47901415-47902082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905147-47905846 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47905847-47906546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47906547-47907244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:47920878-47921870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:47921871-47922864 Neighboring gene Meis homeobox 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway. Irfan M, et al. Sci Rep, 2023 Jan 2. PMID 36593314, Free PMC Article
  2. A putative chemoattractant receptor, C5L2, is expressed in granulocyte and immature dendritic cells, but not in mature dendritic cells. Ohno M, et al. Mol Immunol, 2000 Jun. PMID 11090875
  3. The human complement fragment receptor, C5L2, is a recycling decoy receptor. Scola AM, et al. Mol Immunol, 2009 Mar. PMID 19100624, Free PMC Article
  4. C5a- and ASP-mediated C5L2 activation, endocytosis and recycling are lost in S323I-C5L2 mutation. Cui W, et al. Mol Immunol, 2009 Sep. PMID 19615750
  5. Relationship between a novel polymorphism of the C5L2 gene and coronary artery disease. Zheng YY, et al. PLoS One, 2011. PMID 21698200, Free PMC Article

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
    Title: C5aR2 Regulates STING-Mediated Interferon Beta Production in Human Macrophages.
  2. C5L2 modulates BDNF production in human dental pulp stem cells via p38alpha pathway.
    Title: C5L2 modulates BDNF production in human dental pulp stem cells via p38α pathway.
  3. Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
    Title: Differential expression of C5aR1 and C5aR2 in innate and adaptive immune cells located in early skin lesions of bullous pemphigoid patients.
  4. C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
    Title: C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages.
  5. Expression of C5aR1 and C5aR2 in whole blood was significantly attenuated by IL-6R-inhibition in non-ST-elevation myocardial infarction patients.
    Title: IL-6 Receptor Inhibition by Tocilizumab Attenuated Expression of C5a Receptor 1 and 2 in Non-ST-Elevation Myocardial Infarction.
  6. Both rs2972607 and rs8112962 SNPs of C5L2 are associated with coronary artery disease in a Han population of China.
    Title: Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.
  7. Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR, C5aR1 and C5aR2 to direct the cellular response to inflammation.
    Title: New concepts on the therapeutic control of complement anaphylatoxin receptors.
  8. negative regulator of BDNF secretion by pulp fibroblasts under carious teeth
    Title: C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts.
  9. All the C698T genotypes and allele frequencies in C5L2 were almost similar in both the cases and controls.
    Title: Genetic polymorphisms in paraoxonase 1 and G protein-coupled receptor 77, and the risk of glucose-6-phosphate dehydrogenase deficiency in a Saudi population.
  10. C5AR and C5L2-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
    Title: Complement 5a receptor-mediated neutrophil dysfunction is associated with a poor outcome in sepsis.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See Variation Viewer (GRCh37.p13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in complement component C5a signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of interleukin-8 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basal plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
C5a anaphylatoxin chemotactic receptor 2
Names
C5a anaphylatoxin chemotactic receptor C5L2
G protein-coupled receptor 77
G protein-coupled receptor C5L2
complement component 5a receptor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271749.2 → NP_001258678.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_001258678.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, AK313994
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    B2RA09, Q9P296
    UniProtKB/TrEMBL
    Q6NWQ8, Q6NWQ9
    Related
    ENSP00000472620.1, ENST00000595464.3
    Conserved Domains (1) summary
    pfam00001
    Location:52 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  2. NM_001271750.2 → NP_001258679.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_001258679.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, BP370117
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    B2RA09, Q9P296
    UniProtKB/TrEMBL
    Q6NWQ8, Q6NWQ9
    Conserved Domains (1) summary
    pfam00001
    Location:52 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. NM_018485.3 → NP_060955.1  C5a anaphylatoxin chemotactic receptor 2

    See identical proteins and their annotated locations for NP_060955.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AB038237, AC008754, DA673976
    Consensus CDS
    CCDS12699.1
    UniProtKB/Swiss-Prot
    B2RA09, Q9P296
    UniProtKB/TrEMBL
    Q6NWQ8, Q6NWQ9
    Related
    ENSP00000471184.1, ENST00000600626.1
    Conserved Domains (1) summary
    pfam00001
    Location:52 → 290
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    47332175..47347329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    50157644..50172793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9P296.1 GenPept UniProtKB/Swiss-Prot:Q9P296

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