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Tango6 transport and golgi organization 6 [ Mus musculus (house mouse) ]

Gene ID: 272538, updated on 2-Nov-2024

Summary

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Official Symbol
Tango6provided by MGI
Official Full Name
transport and golgi organization 6provided by MGI
Primary source
MGI:MGI:2142786
See related
Ensembl:ENSMUSG00000041949 AllianceGenome:MGI:2142786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmco7; E330010G16
Summary
Predicted to be involved in protein secretion. Predicted to be located in membrane. Is expressed in aorta; genitourinary system; gut gland; and heart. Orthologous to human TANGO6 (transport and golgi organization 6 homolog). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 3.7), subcutaneous fat pad adult (RPKM 2.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tango6 in Genome Data Viewer
Location:
8 D3; 8 53.18 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107409697..107581175)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106683068..106851439)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110028F18 gene Neighboring gene predicted gene, 39239 Neighboring gene STARR-seq mESC enhancer starr_22570 Neighboring gene cadherin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109171364-109171664 Neighboring gene STARR-seq mESC enhancer starr_22578 Neighboring gene STARR-positive B cell enhancer ABC_E10521 Neighboring gene STARR-seq mESC enhancer starr_22579 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109344486-109344787 Neighboring gene predicted gene, 34197 Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene ES cell cis-regulatory motif 8a Neighboring gene hyaluronan synthase 3 Neighboring gene CTF8, chromosome transmission fidelity factor 8 Neighboring gene DERPC proline and glycine rich nuclear protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry. Feng Z, et al. Nat Commun, 2024 Mar 15. PMID 38490996, Free PMC Article
  2. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.
    Title: TANGO6 regulates cell proliferation via COPI vesicle-mediated RPB2 nuclear entry.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transport and Golgi organization protein 6 homolog
Names
transmembrane and coiled-coil domain-containing protein 7
transmembrane and coiled-coil domains 7
transport and Golgi organization 6 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173037.2 → NP_766625.1  transport and Golgi organization protein 6 homolog

    See identical proteins and their annotated locations for NP_766625.1

    Status: VALIDATED

    Source sequence(s)
    AC140328, AC147500
    Consensus CDS
    CCDS22639.1
    UniProtKB/Swiss-Prot
    Q69ZB6, Q6NXV4, Q8C3S2, Q8C6M0, Q8C8G2
    Related
    ENSMUSP00000043953.5, ENSMUST00000048359.5
    Conserved Domains (3) summary
    pfam10304
    Location:1027 → 1059
    RTP1_C2; Required for nuclear transport of RNA pol II C-terminus 2
    pfam10363
    Location:826 → 929
    RTP1_C1; Required for nuclear transport of RNA pol II C-terminus 1
    sd00044
    Location:861 → 889
    HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107409697..107581175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3S2.1 GenPept UniProtKB/Swiss-Prot:Q8C3S2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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