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Esyt3 extended synaptotagmin-like protein 3 [ Mus musculus (house mouse) ]

Gene ID: 272636, updated on 28-Oct-2024

Summary

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Official Symbol
Esyt3provided by MGI
Official Full Name
extended synaptotagmin-like protein 3provided by MGI
Primary source
MGI:MGI:1098699
See related
Ensembl:ENSMUSG00000037681 AllianceGenome:MGI:1098699
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fam62c; mKIAA4186; D930024E11; D9Ertd280e
Summary
Predicted to enable calcium ion binding activity and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; immune system; and nervous system. Orthologous to human ESYT3 (extended synaptotagmin 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in testis adult (RPKM 7.8), genital fat pad adult (RPKM 4.7) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Esyt3 in Genome Data Viewer
Location:
9 E3.3; 9 51.54 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (99192016..99242210, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (99309963..99360159, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene centrosomal protein 70 Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 8 pseudogene Neighboring gene RIKEN cDNA 4930422M22 gene Neighboring gene DnaJ (Hsp40) homolog, subfamily C, member 14 pseudogene Neighboring gene muscle and microspikes RAS Neighboring gene STARR-seq mESC enhancer starr_25024 Neighboring gene predicted gene, 53543 Neighboring gene RIKEN cDNA 1600029I14 gene Neighboring gene NME/NM23 family member 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders. Zhang Y, et al. Proc Natl Acad Sci U S A, 2020 Aug 18. PMID 32747560, Free PMC Article
  2. Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. Sclip A, et al. PLoS One, 2016. PMID 27348751, Free PMC Article
  3. Loss of Extended Synaptotagmins ESyt2 and ESyt3 does not affect mouse development or viability, but in vitro cell migration and survival under stress are affected. Herdman C, et al. Cell Cycle, 2014. PMID 25486202, Free PMC Article
  4. Cytosolic LPS-induced caspase-11 oligomerization and activation is regulated by extended synaptotagmin 1. Ma Y, et al. Cell Rep, 2023 Jul 25. PMID 37393619, Free PMC Article
  5. Loss of all 3 Extended Synaptotagmins does not affect normal mouse development, viability or fertility. Tremblay MG, et al. Cell Cycle, 2016 Sep. PMID 27399837, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.
    Title: Hypothalamic extended synaptotagmin-3 contributes to the development of dietary obesity and related metabolic disorders.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4186

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphatidylcholine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in endoplasmic reticulum-plasma membrane tethering IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-plasma membrane contact site ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in organelle membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
extended synaptotagmin-3
Names
E-Syt3
family with sequence similarity 62 (C2 domain containing), member C
family with sequence similarity 62, member C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177775.3 → NP_808443.2  extended synaptotagmin-3

    See identical proteins and their annotated locations for NP_808443.2

    Status: VALIDATED

    Source sequence(s)
    AK086367, AK142948, BY754935
    Consensus CDS
    CCDS40739.1
    UniProtKB/Swiss-Prot
    Q0VF61, Q5DTI8, Q8C3B9
    Related
    ENSMUSP00000038757.7, ENSMUST00000042158.13
    Conserved Domains (4) summary
    cd04030
    Location:759 → 884
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:449 → 572
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:310 → 428
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:118 → 294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    99192016..99242210 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511221.5 → XP_006511284.1  extended synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_006511284.1

    UniProtKB/Swiss-Prot
    Q0VF61, Q5DTI8, Q8C3B9
    Conserved Domains (4) summary
    cd04030
    Location:759 → 884
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:449 → 572
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:310 → 428
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:118 → 294
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

  2. XM_011242752.3 → XP_011241054.1  extended synaptotagmin-3 isoform X2

    Conserved Domains (4) summary
    cd04030
    Location:495 → 620
    C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
    cd04050
    Location:185 → 308
    C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
    cd08391
    Location:46 → 164
    C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
    pfam17047
    Location:1 → 30
    SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DTI8.2 GenPept UniProtKB/Swiss-Prot:Q5DTI8

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