P2RY10 P2Y receptor family member 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: P2RY10provided by HGNC
Official Full Name: P2Y receptor family member 10provided by HGNC
Primary source: HGNC:HGNC:19906
See related: Ensembl:ENSG00000078589 MIM:300529; AllianceGenome:HGNC:19906
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LPS2; P2Y10; LYPSR2
Summary: The protein encoded by this gene belongs to the family of G-protein coupled receptors that are preferentially activated by adenosine and uridine nucleotides. There is a pseudogene for this gene nearby on chromosome X. Multiple alternatively spliced transcripts have been observed. [provided by RefSeq, Apr 2016]
Expression: Biased expression in lymph node (RPKM 13.0), appendix (RPKM 8.0) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: Xq21.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (78945391..78963727)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (77382251..77400598)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (78200888..78219224)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Title: G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators.
Our data show that the LysoPS-induced eosinophil degranulation most likely occurs through P2Y10. These findings suggest that LysoPS plays a specific role in eosinophils and introduces the possibility of LysoPS/P2Y10-based therapeutics in the treatment of eosinophilic diseases.
Title: Lysophosphatidylserine receptor P2Y10: A G protein-coupled receptor that mediates eosinophil degranulation.
The P2Y(10) receptor is the first receptor identified as a dual lysophospholipid receptor.
Title: Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

P2RY10_9549 (e-PCR)
- UniSTS:468578

DXS1225 (e-PCR), detects polymorphism
- UniSTS:21214

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: putative P2Y purinoceptor 10

Names: G-protein coupled purinergic receptor P2Y10; P2Y-like receptor; lysophosphatidylserine receptor 2; purinergic receptor P2Y, G-protein coupled, 10; purinergic receptor P2Y10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_013276.2 RefSeqGene

Range

5060..23396

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001324218.2 → NP_001311147.1 putative P2Y purinoceptor 10 isoform a

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 5' UTR compared to variant 1.

Source sequence(s)

BX104083, DB213380, Z82200

Consensus CDS

CCDS14442.1

UniProtKB/Swiss-Prot

D3DTE5, O00398, Q4VBN7, Q86V16

UniProtKB/TrEMBL

A8K7X3

Conserved Domains (1) summary

cd15153
Location:35 → 316

7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_001324221.2 → NP_001311150.1 putative P2Y purinoceptor 10 isoform b

Status: REVIEWED

Description

Transcript Variant: This variant (4) lacks an exon in the 5' region and initiates translation at an upstream alternate start codon compared to variant 1. The encoded isoform (b) has a longer N-terminus than isoform a.

Source sequence(s)

BX104083, DB131258, Z82200

UniProtKB/TrEMBL

A8K7X3

Conserved Domains (1) summary

pfam00001
Location:69 → 322

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_001324225.2 → NP_001311154.1 putative P2Y purinoceptor 10 isoform c

Status: REVIEWED

Description

Transcript Variant: This variant (5) contains an exon and lacks an exon in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a longer N-terminus than isoform a.

Source sequence(s)

BX104083, DA817144, Z82200

UniProtKB/TrEMBL

A8K7X3
NM_014499.4 → NP_055314.1 putative P2Y purinoceptor 10 isoform a

See identical proteins and their annotated locations for NP_055314.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript.

Source sequence(s)

AW294346, BC051875, BX104083, Z82200

Consensus CDS

CCDS14442.1

UniProtKB/Swiss-Prot

D3DTE5, O00398, Q4VBN7, Q86V16

UniProtKB/TrEMBL

A8K7X3

Related

ENSP00000171757.2, ENST00000171757.3

Conserved Domains (1) summary

cd15153
Location:35 → 316

7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_198333.3 → NP_938147.1 putative P2Y purinoceptor 10 isoform a

See identical proteins and their annotated locations for NP_938147.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks two exons in the 5' UTR compared to variant 1.

Source sequence(s)

BC051875, BX104083, CD639881, Z82200

Consensus CDS

CCDS14442.1

UniProtKB/Swiss-Prot

D3DTE5, O00398, Q4VBN7, Q86V16

UniProtKB/TrEMBL

A8K7X3

Related

ENSP00000443138.1, ENST00000544091.1

Conserved Domains (1) summary

cd15153
Location:35 → 316

7tmA_P2Y10; P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors