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Ptdss2 phosphatidylserine synthase 2 [ Mus musculus (house mouse) ]

Gene ID: 27388, updated on 2-Nov-2024

Summary

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Official Symbol
Ptdss2provided by MGI
Official Full Name
phosphatidylserine synthase 2provided by MGI
Primary source
MGI:MGI:1351664
See related
Ensembl:ENSMUSG00000025495 AllianceGenome:MGI:1351664
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PSS2
Summary
Enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Acts upstream of or within phosphatidylserine biosynthetic process. Located in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; liver; lung; and nervous system. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in testis adult (RPKM 133.4), liver E14.5 (RPKM 36.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Ptdss2 in Genome Data Viewer
Location:
7 F5; 7 86.39 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (140711181..140736071)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (141131267..141156158)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene anoctamin 9 Neighboring gene STARR-positive B cell enhancer ABC_E451 Neighboring gene predicted gene, 33560 Neighboring gene ribonuclease/angiogenin inhibitor 1 Neighboring gene STARR-positive B cell enhancer ABC_E8222 Neighboring gene STARR-positive B cell enhancer ABC_E9715 Neighboring gene ribosomal protein S9 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phospholipid homeostasis in phosphatidylserine synthase-2-deficient mice. Steenbergen R, et al. Biochim Biophys Acta, 2006 Mar. PMID 16627002
  2. Phosphatidylserine synthase 2: high efficiency for synthesizing phosphatidylserine containing docosahexaenoic acid. Kimura AK, et al. J Lipid Res, 2013 Jan. PMID 23071296, Free PMC Article
  3. Cloning and expression of murine liver phosphatidylserine synthase (PSS)-2: differential regulation of phospholipid metabolism by PSS1 and PSS2. Stone SJ, et al. Biochem J, 1999 Aug 15. PMID 10432300, Free PMC Article
  4. Defining the importance of phosphatidylserine synthase-1 (PSS1): unexpected viability of PSS1-deficient mice. Arikketh D, et al. J Biol Chem, 2008 May 9. PMID 18343815
  5. Defining the importance of phosphatidylserine synthase 2 in mice. Bergo MO, et al. J Biol Chem, 2002 Dec 6. PMID 12361952

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables CDP-diacylglycerol-serine O-phosphatidyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables L-serine-phosphatidylethanolamine phosphatidyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in phosphatidylserine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylserine biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylserine biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in intracellular anatomical structure IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
phosphatidylserine synthase 2
Names
PSS-2
ptdSer synthase 2
serine-exchange enzyme II
NP_001405348.1
NP_001405349.1
NP_038810.2
XP_006536259.1
XP_006536260.1
XP_030098495.1
XP_030098496.1
XP_030098497.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418419.1 → NP_001405348.1  phosphatidylserine synthase 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272
    Related
    ENSMUST00000173721.8

  2. NM_001418420.1 → NP_001405349.1  phosphatidylserine synthase 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272

  3. NM_013782.5 → NP_038810.2  phosphatidylserine synthase 2 isoform1

    See identical proteins and their annotated locations for NP_038810.2

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272
    Consensus CDS
    CCDS22001.1
    UniProtKB/Swiss-Prot
    Q8BHL2, Q8CCI8, Q8CCY7, Q922A1, Q9CY68, Q9Z1X2
    Related
    ENSMUSP00000026568.9, ENSMUST00000026568.10
    Conserved Domains (1) summary
    pfam03034
    Location:98 → 377
    PSS; Phosphatidyl serine synthase

RNA

  1. NR_184740.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272

  2. NR_184741.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272

  3. NR_184742.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272

  4. NR_184743.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC108908, AC109272

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    140711181..140736071
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030242637.2 → XP_030098497.1  phosphatidylserine synthase 2 isoform X2

    Conserved Domains (1) summary
    pfam03034
    Location:1 → 191
    PSS; Phosphatidyl serine synthase

  2. XM_006536196.5 → XP_006536259.1  phosphatidylserine synthase 2 isoform X1

    Conserved Domains (1) summary
    pfam03034
    Location:55 → 308
    PSS; Phosphatidyl serine synthase

  3. XM_030242635.1 → XP_030098495.1  phosphatidylserine synthase 2 isoform X2

    Conserved Domains (1) summary
    pfam03034
    Location:1 → 191
    PSS; Phosphatidyl serine synthase

  4. XM_006536197.2 → XP_006536260.1  phosphatidylserine synthase 2 isoform X2

    See identical proteins and their annotated locations for XP_006536260.1

    Conserved Domains (1) summary
    pfam03034
    Location:1 → 191
    PSS; Phosphatidyl serine synthase

  5. XM_030242636.1 → XP_030098496.1  phosphatidylserine synthase 2 isoform X2

    Conserved Domains (1) summary
    pfam03034
    Location:1 → 191
    PSS; Phosphatidyl serine synthase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z1X2.2 GenPept UniProtKB/Swiss-Prot:Q9Z1X2

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