U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ip6k1 inositol hexaphosphate kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 27399, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
Ip6k1provided by MGI
Official Full Name
inositol hexaphosphate kinase 1provided by MGI
Primary source
MGI:MGI:1351633
See related
Ensembl:ENSMUSG00000032594 AllianceGenome:MGI:1351633
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ihpk1; InsP6; Itpk6; InsP6k1; 1200016D08Rik
Summary
Predicted to enable inositol hexakisphosphate kinase activity. Involved in negative regulation of cold-induced thermogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in testis adult (RPKM 61.4), ovary adult (RPKM 49.6) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ip6k1 in Genome Data Viewer
Location:
9 F1; 9 59.07 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107879847..107925981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108002648..108048782)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene inka box actin regulator 1 Neighboring gene RIKEN cDNA 4930535L15 gene Neighboring gene cadherin-related family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene STARR-positive B cell enhancer ABC_E2305 Neighboring gene STARR-positive B cell enhancer ABC_E6803 Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene ring finger protein 123 Neighboring gene adhesion molecule with Ig like domain 3

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain. Chakraborty A, et al. Cell, 2010 Dec 10. PMID 21145457, Free PMC Article
  2. IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution. Boregowda SV, et al. Stem Cells, 2017 Aug. PMID 28577302, Free PMC Article
  3. The inositol pyrophosphate pathway in health and diseases. Chakraborty A. Biol Rev Camb Philos Soc, 2018 May. PMID 29282838, Free PMC Article
  4. Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. Yu W, et al. J Biol Chem, 2016 May 13. PMID 26953345, Free PMC Article
  5. Gene deletion of inositol hexakisphosphate kinase 1 reveals inositol pyrophosphate regulation of insulin secretion, growth, and spermiogenesis. Bhandari R, et al. Proc Natl Acad Sci U S A, 2008 Feb 19. PMID 18268345, Free PMC Article

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
    Title: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
  2. Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
    Title: Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
  3. Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
    Title: Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
  4. Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
    Title: Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
  5. Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
    Title: Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
  6. Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
    Title: Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
  7. the unique metabolic sensing properties of IP6K1 guarantees appropriate concentrations of IP7 and thereby both correct basal insulin secretion and intact first phase insulin release.
    Title: Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
  8. juvenile spermatids from Ip6k1(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression.
    Title: IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
  9. these findings reveal an important role for IP6K1 in regulating Mesenchymal stem/stromal cell fitness and differentiation fate.
    Title: IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
  10. IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate.
    Title: Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Potential readthrough

Included gene: Cdhr4

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 1-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol hexakisphosphate kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol hexakisphosphate kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within inositol metabolic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in inositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within inositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
inositol hexakisphosphate kinase 1
Names
inositol hexakisphosphate kinase 6
insP6 kinase 1
NP_038813.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013785.2 → NP_038813.2  inositol hexakisphosphate kinase 1

    See identical proteins and their annotated locations for NP_038813.2

    Status: PROVISIONAL

    Source sequence(s)
    BC059006
    Consensus CDS
    CCDS23514.1
    UniProtKB/Swiss-Prot
    Q6PD10, Q9QXV6
    UniProtKB/TrEMBL
    Q6A097
    Related
    ENSMUSP00000035214.5, ENSMUST00000035214.11
    Conserved Domains (1) summary
    pfam03770
    Location:207 → 426
    IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107879847..107925981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_026266.1: Suppressed sequence

    Description
    NM_026266.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PD10.1 GenPept UniProtKB/Swiss-Prot:Q6PD10

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous