MAT2B methionine adenosyltransferase 2 non-catalytic beta subunit [Homo sapiens (human)] - Gene

Summary

Official Symbol: MAT2Bprovided by HGNC
Official Full Name: methionine adenosyltransferase 2 non-catalytic beta subunitprovided by HGNC
Primary source: HGNC:HGNC:6905
See related: Ensembl:ENSG00000038274 MIM:605527; AllianceGenome:HGNC:6905
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999
Summary: The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Expression: Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 5q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (163503064..163519354)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (164038230..164054512)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (162930070..162946360)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis.
Title: CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis.
Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
Title: Human Mat2A Uses an Ordered Kinetic Mechanism and Is Stabilized but Not Regulated by Mat2B.
lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells.
Title: lncMat2B regulated by severe hypoxia induces cisplatin resistance by increasing DNA damage repair and tumor-initiating population in breast cancer cells.
the protein-protein interacting surface formed in MATa2:MATbeta complexes is explored to demonstrate that several quinolone-based compounds modulate the activity of MATa2 and its mutants, providing a rational for chemical design/intervention responsive to the level of S-Adenosylmethionine in the cellular environment
Title: Control and regulation of S-Adenosylmethionine biosynthesis by the regulatory β subunit and quinolone-based compounds.
Results found that MAT2B was overexpressed in hepatocellular carcinoma (HCC) tissues and correlated with poor prognosis for HCC patients. Its silencing could suppress liver cancer cell migration and invasion through the inhibition of EGFR signaling, which suggested that MAT2B might serve as a new prognostic marker for HCC.
Title: MAT2B mediates invasion and metastasis by regulating EGFR signaling pathway in hepatocellular carcinoma.
MAT2B was markedly increased in osteosarcoma (OS) specimens compared with the normal bone tissues, and it was additionally abundantly expressed in OS cell lines. Inhibition of MAT2B expression caused a marked decrease in proliferation and significant increase in apoptosis. Results demonstrated that MAT2B functions as a tumor oncogene in OS in vivo and in vitro via regulation of EGFR and PCNA.
Title: MAT2B promotes proliferation and inhibits apoptosis in osteosarcoma by targeting epidermal growth factor receptor and proliferating cell nuclear antigen.
This study showed that variant upstream of MAT2B whose association is prominent in back, hip, knee, and neck pain-provides preliminary evidence of shared contributing mechanisms at the genetic-molecular level.
Title: Genetic studies of human neuropathic pain conditions: a review.
Results show that MAT2B expression is frequently upregulated in malignant melanoma tissues. MAT2B downregulation delays tumor growth in vivo, and suppressed cell growth, colony formation ability and induced apoptosis in vitro indicating that MAT2B is critical for melanoma cell proliferation and tumorigenicity.
Title: Lentivirus-mediated downregulation of MAT2B inhibits cell proliferation and induces apoptosis in melanoma.
Interaction between MAT2B and GIT1 serves as a scaffold and facilitates signaling in multiple steps of the Ras/Raf/MEK/ERK pathway
Title: Methionine adenosyltransferase 2B-GIT1 complex serves as a scaffold to regulate Ras/Raf/MEK1/2 activity in human liver and colon cancer cells.
Mutagenesis of MATalpha2 and MATbeta phospho-sites destabilized them and prevented hepatic stellate cell trans-differentiation.
Title: Role of methionine adenosyltransferase α2 and β phosphorylation and stabilization in human hepatic stellate cell trans-differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study of smoking behaviours among Bangladeshi adults. EBI GWAS Catalog EBI GWAS CatalogPubMed
Linkage and association of successful aging to the 6q25 region in large Amish kindreds. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH93678 (e-PCR)
- UniSTS:89867

STS-D25599 (e-PCR)
- UniSTS:73833

G35510 (e-PCR)
- UniSTS:44150

D5S1942 (e-PCR)
- UniSTS:154273

SHGC-56899 (e-PCR)
- UniSTS:34793

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables methionine adenosyltransferase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
part_of methionine adenosyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of methionine adenosyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
part_of methionine adenosyltransferase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: methionine adenosyltransferase 2 subunit beta

Names: MAT II beta; beta regulatory subunit of methionine adenosyltransferase; dTDP-4-keto-6-deoxy-D-glucose 4-reductase; methionine adenosyltransferase 2B; methionine adenosyltransferase II, beta; putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase; putative protein product of Nbla02999; short chain dehydrogenase/reductase family 23E, member 1; testicular tissue protein Li 118

NP_037415.1

EC 2.5.1.6

NP_877725.1

EC 2.5.1.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013283.5 → NP_037415.1 methionine adenosyltransferase 2 subunit beta isoform 1

See identical proteins and their annotated locations for NP_037415.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AC112205, AK096178, AK312365, HY366761

Consensus CDS

CCDS4365.1

UniProtKB/Swiss-Prot

B2R5Y6, Q1WAI7, Q27J92, Q3LIE8, Q567T7, Q6NYC7, Q9BS89, Q9H3E1, Q9NZL9, Q9UJ54

UniProtKB/TrEMBL

A0A140VJP2, A0A8Q3WK80

Related

ENSP00000325425.6, ENST00000321757.11

Conserved Domains (1) summary

cd05254
Location:30 → 316

dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs
NM_182796.2 → NP_877725.1 methionine adenosyltransferase 2 subunit beta isoform 2

See identical proteins and their annotated locations for NP_877725.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region but maintains the reading frame, compared to variant 1. These differences result in a shorter isoform (2) with a distinct N-terminus, compared to isoform 1.

Source sequence(s)

AK096178, AY358695, HY091756, HY366761

Consensus CDS

CCDS4364.1

UniProtKB/TrEMBL

A8K7A4

Related

ENSP00000280969.5, ENST00000280969.9

Conserved Domains (1) summary

cd05254
Location:19 → 305

dTDP_HR_like_SDR_e; dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs