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Fs Follistatin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 2768836, updated on 2-Nov-2024

Summary

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Official Symbol
Fsprovided by FlyBase
Official Full Name
Follistatinprovided by FlyBase
Primary source
FLYBASE:FBgn0259878
Locus tag
Dmel_CG33466
See related
AllianceGenome:FB:FBgn0259878
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12955; CG12956; CG33466; dFol1; dfs; dFS; Dmel\CG33466; Fol1; fs
Summary
Enables activin binding activity. Involved in negative regulation of BMP signaling pathway; negative regulation of activin receptor signaling pathway; and positive regulation of activin receptor signaling pathway. Located in extracellular region. Is expressed in several structures, including brain; germline cell; gonad; imaginal disc; and photoreceptor. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to several human genes including FST (follistatin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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Location:
51E7-51E10; 2-74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (15223560..15241589, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11111065..11129094, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44463 Neighboring gene antisense RNA:CR44370 Neighboring gene uncharacterized protein Neighboring gene Hexokinase C Neighboring gene scab Neighboring gene Integrin alphaPS4 subunit Neighboring gene Transient receptor potential cation channel, subfamily M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation of Drosophila activin and follistatin cDNAs using novel MACH amplification protocols. Haerry TE, et al. Gene, 2002 May 29. PMID 12095682
  2. Drosophila activins adapt gut size to food intake and promote regenerative growth. Christensen CF, et al. Nat Commun, 2024 Jan 4. PMID 38177201, Free PMC Article
  3. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin. Herrera SC, et al. Dev Cell, 2021 Aug 23. PMID 34363758, Free PMC Article
  4. Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members. Bickel D, et al. Mech Dev, 2008 Jan-Feb. PMID 18077144, Free PMC Article
  5. Follistatin preferentially antagonizes activin rather than BMP signaling in Drosophila. Pentek J, et al. Genesis, 2009 Apr. PMID 19241394

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
    Title: Proliferative stem cells maintain quiescence of their niche by secreting the Activin inhibitor Follistatin.
  2. FS proteins may also function in facilitating ligand diffusion. We find that mutants of daw are rescued in significant numbers by expression of vertebrate follistatin (FS) proteins
    Title: Drosophila Follistatin exhibits unique structural modifications and interacts with several TGF-beta family members.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables activin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of activin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
follistatin
Names
CG33466-PA
CG33466-PB
Fs-PA
Fs-PB
dFollistatin
follistatin 1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    15223560..15241589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299516.1 → NP_001286445.1  follistatin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286445.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LFH4, Q8WR59
    Conserved Domains (2) summary
    smart00280
    Location:563 → 603
    KAZAL; Kazal type serine protease inhibitors
    cd00104
    Location:653 → 686
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  2. NM_144119.3 → NP_652376.2  follistatin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652376.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q86NV3, Q8WR59
    Conserved Domains (2) summary
    smart00280
    Location:564 → 604
    KAZAL; Kazal type serine protease inhibitors
    cd00104
    Location:654 → 687
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4LFH4 A0A0B4LFH4
Q86NV3 Q86NV3
Q8WR59 Q8WR59

Gene LinkOut

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