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Zdhhc8 zinc finger, DHHC domain containing 8 [ Mus musculus (house mouse) ]

Gene ID: 27801, updated on 2-Nov-2024

Summary

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Official Symbol
Zdhhc8provided by MGI
Official Full Name
zinc finger, DHHC domain containing 8provided by MGI
Primary source
MGI:MGI:1338012
See related
Ensembl:ENSMUSG00000060166 AllianceGenome:MGI:1338012
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DHHC-8; Op53c05; ZDHHCL1; D16H22S1738E; E330009O14Rik
Summary
Predicted to enable palmitoyltransferase activity. Involved in regulation of postsynapse assembly. Acts upstream of or within locomotory behavior. Located in mitochondrion. Is active in glutamatergic synapse and postsynapse. Is expressed in several structures, including brain; cardiovascular system; forelimb bud; ganglia; and nose. Orthologous to human ZDHHC8 (zinc finger DHHC-type palmitoyltransferase 8). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in thymus adult (RPKM 67.5), ovary adult (RPKM 44.5) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Zdhhc8 in Genome Data Viewer
Location:
16 A3; 16 11.29 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (18038612..18056471, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (18220748..18235153, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933432I09 gene Neighboring gene coiled-coil domain containing 188 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:18231149-18231350 Neighboring gene predicted gene, 25777 Neighboring gene RAN binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E8621 Neighboring gene TRM2 tRNA methyltransferase 2A Neighboring gene DGCR8, microprocessor complex subunit

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hippocampal-prefrontal theta-gamma coupling during performance of a spatial working memory task. Tamura M, et al. Nat Commun, 2017 Dec 19. PMID 29259151, Free PMC Article
  2. Molecular substrates of altered axonal growth and brain connectivity in a mouse model of schizophrenia. Mukai J, et al. Neuron, 2015 May 6. PMID 25913858, Free PMC Article
  3. Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion. Mukai J, et al. Nat Neurosci, 2008 Nov. PMID 18836441, Free PMC Article
  4. Ankyrin-G palmitoylation and βII-spectrin binding to phosphoinositide lipids drive lateral membrane assembly. He M, et al. J Cell Biol, 2014 Jul 21. PMID 25049274, Free PMC Article
  5. S-nitrosylation and S-palmitoylation reciprocally regulate synaptic targeting of PSD-95. Ho GP, et al. Neuron, 2011 Jul 14. PMID 21745643, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (1)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7847, MGC103030, MGC118171

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in peptidyl-L-cysteine S-palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation by host of viral process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation by host of viral process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cholesterol efflux ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein palmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
 PubMed 

General protein information

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Preferred Names
palmitoyltransferase ZDHHC8
Names
DHHC-containing protein 8
probable palmitoyltransferase ZDHHC8
zinc finger DHHC domain-containing protein 8
NP_001365948.1
NP_742163.4
XP_006522287.1
XP_036015869.1
XP_036015870.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379019.1 → NP_001365948.1  palmitoyltransferase ZDHHC8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC084822, AC118542
    UniProtKB/TrEMBL
    Q2TGE7
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    DHHC; DHHC palmitoyltransferase

  2. NM_172151.4 → NP_742163.4  palmitoyltransferase ZDHHC8 isoform 1

    See identical proteins and their annotated locations for NP_742163.4

    Status: VALIDATED

    Source sequence(s)
    AY668947, AY894892
    Consensus CDS
    CCDS28017.1
    UniProtKB/Swiss-Prot
    Q5Y5T5, Q7TNF7
    UniProtKB/TrEMBL
    Q2TGE7
    Related
    ENSMUSP00000076224.6, ENSMUST00000076957.7
    Conserved Domains (1) summary
    pfam01529
    Location:99 → 224
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    18038612..18056471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006522224.5 → XP_006522287.1  palmitoyltransferase ZDHHC8 isoform X1

    See identical proteins and their annotated locations for XP_006522287.1

    UniProtKB/TrEMBL
    Q2TGE7
    Conserved Domains (1) summary
    cl19890
    Location:28 → 171
    DHHC; DHHC palmitoyltransferase

  2. XM_036159976.1 → XP_036015869.1  palmitoyltransferase ZDHHC8 isoform X2

  3. XM_036159977.1 → XP_036015870.1  palmitoyltransferase ZDHHC8 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5Y5T5.1 GenPept UniProtKB/Swiss-Prot:Q5Y5T5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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