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GNG3 G protein subunit gamma 3 [ Homo sapiens (human) ]

Gene ID: 2785, updated on 5-Mar-2024

Summary

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Official Symbol
GNG3provided by HGNC
Official Full Name
G protein subunit gamma 3provided by HGNC
Primary source
HGNC:HGNC:4405
See related
Ensembl:ENSG00000162188 MIM:608941; AllianceGenome:HGNC:4405
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HG3D
Summary
Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The gamma subunit determines the specificity of which signaling pathways will be affected by this particular complex. The protein encoded by this gene represents the gamma subunit of both inhibitory and stimulatory complexes. [provided by RefSeq, Jan 2012]
Expression
Biased expression in brain (RPKM 92.3), adrenal (RPKM 8.1) and 1 other tissue See more
Orthologs
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Genomic context

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See GNG3 in Genome Data Viewer
Location:
11q12.3
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62706446..62709201)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62695866..62698618)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62475148..62476673)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4839 Neighboring gene UBX domain protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62455030-62455530 Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene LRRN4 C-terminal like Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62465704-62466296 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62473607-62474280 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:62475600-62476799 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62482895-62483396 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4843 Neighboring gene tetratricopeptide repeat domain 9C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulation of Golgi structure and secretion by receptor-induced G protein βγ complex translocation. Saini DK, et al. Proc Natl Acad Sci U S A, 2010 Jun 22. PMID 20534534, Free PMC Article
  2. KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation. Bell B, et al. J Biol Chem, 1999 Mar 19. PMID 10075696
  3. Mice with deficiency of G protein gamma3 are lean and have seizures. Schwindinger WF, et al. Mol Cell Biol, 2004 Sep. PMID 15314181, Free PMC Article
  4. Differential localization of the gamma 3 and gamma 12 subunits of G proteins in the mammalian brain. Morishita R, et al. J Neurochem, 1997 Feb. PMID 9003074
  5. Lipid modifications of trimeric G proteins. Wedegaertner PB, et al. J Biol Chem, 1995 Jan 13. PMID 7822269

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of guanine nucleotide binding protein (G protein), gamma 3 (GNG3) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G-protein beta-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell body IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3
Names
NBP gamma-3
guanine nucleotide binding protein (G protein), gamma 3
guanine nucleotide-binding protein gamma-3 subunit
heterotrimeric guanine nucleotide-binding protein 3D

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012202.5 → NP_036334.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3

    See identical proteins and their annotated locations for NP_036334.1

    Status: REVIEWED

    Source sequence(s)
    AF087900, AF092129, AP001458, DA123305
    Consensus CDS
    CCDS8032.1
    UniProtKB/Swiss-Prot
    B2R4S7, P29798, P63215, Q61014
    Related
    ENSP00000294117.5, ENST00000294117.6
    Conserved Domains (1) summary
    smart00224
    Location:13 → 75
    GGL; G protein gamma subunit-like motifs

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62706446..62709201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426794.1 → XP_047282750.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

    UniProtKB/Swiss-Prot
    B2R4S7, P29798, P63215, Q61014

  2. XM_006718500.3 → XP_006718563.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

    See identical proteins and their annotated locations for XP_006718563.1

    UniProtKB/Swiss-Prot
    B2R4S7, P29798, P63215, Q61014
    Conserved Domains (1) summary
    smart00224
    Location:13 → 75
    GGL; G protein gamma subunit-like motifs

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62695866..62698618
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368464.1 → XP_054224439.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

    UniProtKB/Swiss-Prot
    B2R4S7, P29798, P63215, Q61014

  2. XM_054368463.1 → XP_054224438.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 isoform X1

    UniProtKB/Swiss-Prot
    B2R4S7, P29798, P63215, Q61014
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63215.1 GenPept UniProtKB/Swiss-Prot:P63215

Gene LinkOut

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