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Efhd2 EF hand domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 27984, updated on 17-Aug-2024

Summary

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Official Symbol
Efhd2provided by MGI
Official Full Name
EF hand domain containing 2provided by MGI
Primary source
MGI:MGI:106504
See related
Ensembl:ENSMUSG00000040659 AllianceGenome:MGI:106504
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D4Wsu27e; 2600015J22Rik
Summary
Enables calcium ion binding activity. Predicted to be located in membrane. Is expressed in brain; embryo endoderm; extraembryonic component; gut; and heart. Orthologous to human EFHD2 (EF-hand domain family member D2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 142.8), small intestine adult (RPKM 133.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Efhd2 in Genome Data Viewer
Location:
4 D3; 4 74.75 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (141585453..141602231, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (141858142..141874920, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene chymotrypsin C Neighboring gene chymotrypsin C, opposite strand Neighboring gene predicted gene, 35034 Neighboring gene forkhead-associated phosphopeptide binding domain 1, opposite strand 2 Neighboring gene predicted gene, 46874 Neighboring gene forkhead-associated phosphopeptide binding domain 1 Neighboring gene predicted gene, 42338

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. EFhd2 brain interactome reveals its association with different cellular and molecular processes. Soliman AS, et al. J Neurochem, 2021 Dec. PMID 34543436, Free PMC Article
  2. Swiprosin1/EFhd2 is involved in the monoaminergic and locomotor responses of psychostimulant drugs. Kogias G, et al. J Neurochem, 2020 Aug. PMID 31943210
  3. Swiprosin-1 deficiency impairs macrophage immune response of septic mice. Zhang S, et al. JCI Insight, 2018 Feb 8. PMID 29415882, Free PMC Article
  4. EFhd2/swiprosin-1 regulates LPS-induced macrophage recruitment via enhancing actin polymerization and cell migration. Tu Y, et al. Int Immunopharmacol, 2018 Feb. PMID 29288926
  5. Low level of swiprosin-1/EFhd2 in vestibular nuclei of spontaneously hypersensitive motion sickness mice. Wang ZB, et al. Sci Rep, 2017 Jan 27. PMID 28128226, Free PMC Article

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis.
    Title: EFHD2 regulates T cell receptor signaling and modulates T helper cell activation in early sepsis.
  2. EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.
    Title: EFHD2 suppresses intestinal inflammation by blocking intestinal epithelial cell TNFR1 internalization and cell death.
  3. miRNA-126a-3p participates in hippocampal memory via alzheimer's disease-related proteins.
    Title: miRNA-126a-3p participates in hippocampal memory via alzheimer's disease-related proteins.
  4. Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.
    Title: Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure.
  5. EFhd2 brain interactome reveals its association with different cellular and molecular processes.
    Title: EFhd2 brain interactome reveals its association with different cellular and molecular processes.
  6. B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2.
    Title: B Cell Speed and B-FDC Contacts in Germinal Centers Determine Plasma Cell Output via Swiprosin-1/EFhd2.
  7. Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.
    Title: Swiprosin-1/EFhD-2 Expression in Cardiac Remodeling and Post-Infarct Repair: Effect of Ischemic Conditioning.
  8. Study in LPS-induced or cecal ligation and puncture-induced sepsis in mice report that swiprosin-1 (also known as EFhd2) plays an important role in the macrophage immune response to sepsis in mice. Swiprosin-1 depletion causes higher mortality, more severe organ dysfunction, restrained macrophage recruitment in the lung and kidney, and attenuated inflammatory cytokine production.
    Title: Swiprosin-1 deficiency impairs macrophage immune response of septic mice.
  9. EFHD2 is an important regulator of T cell cytotoxicity and further studies should evaluate its role in T cell-mediated inflammation
    Title: EF Hand Domain Family Member D2 Is Required for T Cell Cytotoxicity.
  10. Together with our finding of severe hippocampal tauopathy in Efhd2 knockout mice, these data connect Efhd2 to impaired synaptic plasticity as present in Alzheimer's disease and identify a role of Efhd2 in neuronal survival and synaptic integration in the adult hippocampus
    Title: Impact of Swiprosin-1/Efhd2 on Adult Hippocampal Neurogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein D2
Names
swiprosin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025994.3 → NP_080270.2  EF-hand domain-containing protein D2

    See identical proteins and their annotated locations for NP_080270.2

    Status: PROVISIONAL

    Source sequence(s)
    AK048475
    Consensus CDS
    CCDS18885.1
    UniProtKB/Swiss-Prot
    Q9D0P4, Q9D8Y0
    UniProtKB/TrEMBL
    Q8C845
    Related
    ENSMUSP00000044502.4, ENSMUST00000036854.4
    Conserved Domains (2) summary
    cd00051
    Location:96 → 154
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam13499
    Location:97 → 154
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    141585453..141602231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9D8Y0.1 GenPept UniProtKB/Swiss-Prot:Q9D8Y0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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