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Cttnbp2 cortactin binding protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282587, updated on 14-Nov-2024

Summary

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Official Symbol
Cttnbp2provided by RGD
Official Full Name
cortactin binding protein 2provided by RGD
Primary source
RGD:628691
See related
EnsemblRapid:ENSRNOG00000061845 AllianceGenome:RGD:628691
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cbp90; Cortbp2
Summary
Enables SH3 domain binding activity. Involved in regulation of modification of postsynaptic actin cytoskeleton. Located in synaptic vesicle. Is active in glutamatergic synapse. Orthologous to human CTTNBP2 (cortactin binding protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Brain (RPKM 168.9), Adrenal (RPKM 67.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Cttnbp2 in Genome Data Viewer
Location:
4q22
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (47766867..47930598, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (46800975..46964681, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (42932897..43096454, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene CF transmembrane conductance regulator Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134486734 Neighboring gene uncharacterized LOC120102241 Neighboring gene U2 snRNP-associated SURP domain containing, pseudogene 1 Neighboring gene uncharacterized LOC134486735

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms. Shih PY, et al. Acta Neuropathol Commun, 2020 Nov 9. PMID 33168105, Free PMC Article
  2. Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization. Shih PY, et al. J Cell Sci, 2014 Aug 15. PMID 24928895
  3. Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance. Chen YK, et al. J Neurosci, 2012 Jan 18. PMID 22262902, Free PMC Article
  4. Isolation and characterization of cortactin isoforms and a novel cortactin-binding protein, CBP90. Ohoka Y, et al. Genes Cells, 1998 Sep. PMID 9813110
  5. Comparative analyses of multi-species sequences from targeted genomic regions. Thomas JW, et al. Nature, 2003 Aug 14. PMID 12917688

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
    Title: Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms.
  2. Cttnbp2 increases microtubule stability and regulates dendritic arborization.
    Title: Cortactin-binding protein 2 increases microtubule stability and regulates dendritic arborization.
  3. This sst=udy demonistrated that Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
    Title: Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of modification of postsynaptic actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of modification of postsynaptic actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synapse organization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synapse organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of FAR/SIN/STRIPAK complex ISO
Inferred from Sequence Orthology
more info
  
part_of FAR/SIN/STRIPAK complex ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
  
located_in dendritic spine ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in glutamatergic synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cortactin-binding protein 2
Names
brain specific cortactin-binding protein CBP90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114401.1 → NP_001107873.1  cortactin-binding protein 2

    See identical proteins and their annotated locations for NP_001107873.1

    Status: PROVISIONAL

    Source sequence(s)
    DP000027
    UniProtKB/Swiss-Prot
    O88864, Q2IBD4
    UniProtKB/TrEMBL
    A0A8I5YC08
    Related
    ENSRNOP00000072761.1, ENSRNOT00000087167.3
    Conserved Domains (8) summary
    PRK11331
    Location:1077 → 1357
    PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
    cd00204
    Location:728 → 853
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam09486
    Location:108 → 258
    HrpB7; Bacterial type III secretion protein (HrpB7)
    pfam09727
    Location:36 → 179
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:738 → 829
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:702 → 754
    Ank_4; Ankyrin repeats (many copies)
    pfam13863
    Location:135 → 228
    DUF4200; Domain of unknown function (DUF4200)
    sd00045
    Location:766 → 797
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    47766867..47930598 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107159.2 → XP_038963087.1  cortactin-binding protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5YC08
    Related
    ENSRNOP00000077746.1, ENSRNOT00000120156.2
    Conserved Domains (6) summary
    PRK11331
    Location:1036 → 1318
    PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
    PHA03247
    Location:317 → 669
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:725 → 756
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:134 → 476
    CCDC158; Coiled-coil domain-containing protein 158
    pfam09727
    Location:36 → 179
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:697 → 791
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_017592494.3 → XP_017447983.1  cortactin-binding protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YC08

  3. XM_039107160.2 → XP_038963088.1  cortactin-binding protein 2 isoform X3

    Conserved Domains (6) summary
    PRK11331
    Location:1077 → 1267
    PRK11331; 5-methylcytosine-specific restriction enzyme subunit McrB; Provisional
    PHA03247
    Location:272 → 703
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:766 → 797
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:134 → 476
    CCDC158; Coiled-coil domain-containing protein 158
    pfam09727
    Location:36 → 179
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:738 → 832
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_039107161.2 → XP_038963089.1  cortactin-binding protein 2 isoform X4

    Conserved Domains (6) summary
    PHA02874
    Location:702 → 909
    PHA02874; ankyrin repeat protein; Provisional
    PHA03247
    Location:276 → 703
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:766 → 797
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:134 → 476
    CCDC158; Coiled-coil domain-containing protein 158
    pfam09727
    Location:36 → 179
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:738 → 832
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_039107162.2 → XP_038963090.1  cortactin-binding protein 2 isoform X5

    Conserved Domains (5) summary
    PHA03247
    Location:276 → 703
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:702 → 731
    ANK; ANK repeat [structural motif]
    pfam15921
    Location:134 → 476
    CCDC158; Coiled-coil domain-containing protein 158
    pfam09727
    Location:36 → 179
    CortBP2; Cortactin-binding protein-2
    pfam12796
    Location:704 → 781
    Ank_2; Ankyrin repeats (3 copies)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2IBD4.1 GenPept UniProtKB/Swiss-Prot:Q2IBD4

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