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Elac2 elaC ribonuclease Z 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 282826, updated on 17-Aug-2024

Summary

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Official Symbol
Elac2provided by RGD
Official Full Name
elaC ribonuclease Z 2provided by RGD
Primary source
RGD:628882
See related
EnsemblRapid:ENSRNOG00000003424 AllianceGenome:RGD:628882
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 3'-tRNA processing endoribonuclease activity and tRNA-specific ribonuclease activity. Predicted to be involved in mitochondrial tRNA 3'-trailer cleavage, endonucleolytic. Predicted to be located in mitochondrial nucleoid and nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 17. Orthologous to human ELAC2 (elaC ribonuclease Z 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 108.7), Adrenal (RPKM 101.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Elac2 in Genome Data Viewer
Location:
10q24
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (50131449..50154755)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (49632308..49655614)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (51478378..51501167)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480806 Neighboring gene uncharacterized LOC134480807 Neighboring gene Rho GTPase activating protein 44 Neighboring gene uncharacterized LOC134480809 Neighboring gene uncharacterized LOC134480808

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Naturally occurring mutations in human mitochondrial pre-tRNASer(UCN) can affect the transfer ribonuclease Z cleavage site, processing kinetics, and substrate secondary structure. Yan H, et al. J Biol Chem, 2006 Feb 17. PMID 16361254
  2. Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Dumont M, et al. Biochim Biophys Acta, 2004 Sep 17. PMID 15358515
  3. 3' processing of eukaryotic precursor tRNAs. Maraia RJ, et al. Wiley Interdiscip Rev RNA, 2011 May-Jun. PMID 21572561, Free PMC Article
  4. Localization of human RNase Z isoforms: dual nuclear/mitochondrial targeting of the ELAC2 gene product by alternative translation initiation. Rossmanith W. PLoS One, 2011 Apr 29. PMID 21559454, Free PMC Article
  5. Functional analyses for tRNase Z variants: an aspartate and a histidine in the active site are essential for the catalytic activity. Elbarbary RA, et al. Biochim Biophys Acta, 2008 Dec. PMID 18809514

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3'-tRNA processing endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-tRNA processing endoribonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific ribonuclease activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in mitochondrial tRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitochondrial tRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial tRNA 3'-end processing ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial tRNA 3'-end processing ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tRNA 3'-end processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrial nucleoid IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial nucleoid ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial nucleoid ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc phosphodiesterase ELAC protein 2
Names
RNase Z 2
elaC homolog 2
elaC homolog protein 2
ribonuclease Z 2
tRNA 3 endonuclease 2
tRNase Z 2
NP_758829.2
XP_038941246.1
XP_038941247.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172326.2 → NP_758829.2  zinc phosphodiesterase ELAC protein 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q8CGS5
    UniProtKB/TrEMBL
    A6HFE9, G3V6F5
    Related
    ENSRNOP00000004722.3, ENSRNOT00000004722.6
    Conserved Domains (2) summary
    cd07718
    Location:482 → 687
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:54 → 310
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    50131449..50154755
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085319.1 → XP_038941247.1  zinc phosphodiesterase ELAC protein 2 isoform X2

    Conserved Domains (1) summary
    cl23716
    Location:54 → 310
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain

  2. XM_039085318.2 → XP_038941246.1  zinc phosphodiesterase ELAC protein 2 isoform X1

    Conserved Domains (2) summary
    cd07718
    Location:111 → 316
    RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold; Ribonuclease Z ELAC1, C-terminus of ELAC2, and related proteins; MBL-fold metallo-hydrolase domain
    cl23716
    Location:286 → 358
    metallo-hydrolase-like_MBL-fold; mainly hydrolytic enzymes and related proteins which carry out various biological functions; MBL-fold metallohydrolase domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CGS5.1 GenPept UniProtKB/Swiss-Prot:Q8CGS5

Gene LinkOut

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