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FUOM fucose mutarotase [ Homo sapiens (human) ]

Gene ID: 282969, updated on 2-Nov-2024

Summary

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Official Symbol
FUOMprovided by HGNC
Official Full Name
fucose mutarotaseprovided by HGNC
Primary source
HGNC:HGNC:24733
See related
Ensembl:ENSG00000148803 MIM:617725; AllianceGenome:HGNC:24733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FUCU; FucM; C10orf125
Summary
Predicted to enable L-fucose mutarotase activity and fucose binding activity. Predicted to be involved in fucose metabolic process and fucosylation. Predicted to act upstream of or within female mating behavior and negative regulation of neuron differentiation. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in liver (RPKM 9.1), duodenum (RPKM 5.8) and 21 other tissues See more
Orthologs
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Genomic context

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See FUOM in Genome Data Viewer
Location:
10q26.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133352773..133358019, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134310274..134313135, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135168662..135171523, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene proline rich acidic protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135169540-135170274 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2976 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:135172784-135172946 Neighboring gene enoyl-CoA hydratase, short chain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2977 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4248 Neighboring gene uncharacterized LOC124902563 Neighboring gene microRNA 3944 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135191859-135192358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2978

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization and role of fucose mutarotase in mammalian cells. Park D, et al. Glycobiology, 2007 Sep. PMID 17602138
  2. Crystal structures and enzyme mechanisms of a dual fucose mutarotase/ribose pyranase. Lee KH, et al. J Mol Biol, 2009 Aug 7. PMID 19524593
  3. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Taipale M, et al. Cell, 2014 Jul 17. PMID 25036637, Free PMC Article
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article
  5. A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling. Kumar P, et al. J Proteome Res, 2017 Aug 4. PMID 28675297, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ26016, MGC149258

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables L-fucose mutarotase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables fucose binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fucose binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables racemase and epimerase activity, acting on carbohydrates and derivatives IBA
Inferred from Biological aspect of Ancestor
more info
  
enables racemase and epimerase activity, acting on carbohydrates and derivatives ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in fucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
fucose mutarotase
Names
protein fucU homolog
NP_001091953.1
NP_001288756.1
NP_001288757.1
NP_940874.2
XP_011537972.1
XP_011537973.1
XP_011537974.1
XP_011537975.1
XP_011537976.1
XP_011537977.1
XP_047281057.1
XP_047281058.1
XP_047281059.1
XP_047281060.1
XP_047281061.1
XP_054221594.1
XP_054221595.1
XP_054221596.1
XP_054221597.1
XP_054221598.1
XP_054221599.1
XP_054221600.1
XP_054221601.1
XP_054221602.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001098483.3 → NP_001091953.1  fucose mutarotase isoform 1

    See identical proteins and their annotated locations for NP_001091953.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AI333356, HY163253
    Consensus CDS
    CCDS44499.1
    UniProtKB/Swiss-Prot
    A1L300, A2VDF0, Q5VWY2, Q5VWY3, Q6ZPD2
    UniProtKB/TrEMBL
    X6RK00
    Related
    ENSP00000278025.5, ENST00000278025.9
    Conserved Domains (1) summary
    cl00809
    Location:4 → 147
    RbsD_FucU; RbsD / FucU transport protein family

  2. NM_001301827.2 → NP_001288756.1  fucose mutarotase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AI333356, AK129527, BM009909
    UniProtKB/TrEMBL
    X6RK00
    Related
    ENSP00000413379.2, ENST00000447176.5
    Conserved Domains (1) summary
    cl00809
    Location:4 → 124
    RbsD_FucU; RbsD / FucU transport protein family

  3. NM_001301828.2 → NP_001288757.1  fucose mutarotase isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' region, and it thus differs in its 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (4) is shorter at the N-terminus, compared to isoform 1.
    Source sequence(s)
    AI333356, AK129527, BU849497
    Consensus CDS
    CCDS76364.1
    UniProtKB/TrEMBL
    X6R6T9, X6RK00
    Related
    ENST00000465384.5
    Conserved Domains (1) summary
    cl00809
    Location:3 → 102
    RbsD_FucU; RbsD / FucU transport protein family

  4. NM_198472.3 → NP_940874.2  fucose mutarotase isoform 2

    See identical proteins and their annotated locations for NP_940874.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK129527, BC129819, CN368132
    Consensus CDS
    CCDS7680.1
    UniProtKB/Swiss-Prot
    A2VDF0
    Related
    ENSP00000357540.5, ENST00000368552.8
    Conserved Domains (1) summary
    cl00809
    Location:4 → 133
    RbsD_FucU; RbsD / FucU transport protein family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133352773..133358019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539675.3 → XP_011537977.1  fucose mutarotase isoform X11

    Related
    ENSP00000520888.1, ENST00000850601.1
    Conserved Domains (1) summary
    cl00809
    Location:4 → 133
    RbsD_FucU; RbsD / FucU transport protein family

  2. XM_011539673.3 → XP_011537975.1  fucose mutarotase isoform X10

    Conserved Domains (1) summary
    cl00809
    Location:4 → 144
    RbsD_FucU; RbsD / FucU transport protein family

  3. XM_011539671.3 → XP_011537973.1  fucose mutarotase isoform X2

    Conserved Domains (1) summary
    cl00809
    Location:4 → 158
    RbsD_FucU; RbsD / FucU transport protein family

  4. XM_011539672.3 → XP_011537974.1  fucose mutarotase isoform X3

    Conserved Domains (1) summary
    cl00809
    Location:4 → 158
    RbsD_FucU; RbsD / FucU transport protein family

  5. XM_011539670.3 → XP_011537972.1  fucose mutarotase isoform X1

    Conserved Domains (1) summary
    cl00809
    Location:4 → 169
    RbsD_FucU; RbsD / FucU transport protein family

  6. XM_011539674.3 → XP_011537976.1  fucose mutarotase isoform X4

    Conserved Domains (1) summary
    cl00809
    Location:4 → 144
    RbsD_FucU; RbsD / FucU transport protein family

  7. XM_047425105.1 → XP_047281061.1  fucose mutarotase isoform X9

    UniProtKB/TrEMBL
    X6R6T9
    Related
    ENSP00000357539.1, ENST00000368551.1

  8. XM_047425102.1 → XP_047281058.1  fucose mutarotase isoform X6

  9. XM_047425103.1 → XP_047281059.1  fucose mutarotase isoform X7

  10. XM_047425101.1 → XP_047281057.1  fucose mutarotase isoform X5

  11. XM_047425104.1 → XP_047281060.1  fucose mutarotase isoform X8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134310274..134313135 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365621.1 → XP_054221596.1  fucose mutarotase isoform X3

  2. XM_054365622.1 → XP_054221597.1  fucose mutarotase isoform X4

  3. XM_054365625.1 → XP_054221600.1  fucose mutarotase isoform X7

  4. XM_054365627.1 → XP_054221602.1  fucose mutarotase isoform X9

    UniProtKB/TrEMBL
    X6R6T9

  5. XM_054365620.1 → XP_054221595.1  fucose mutarotase isoform X2

  6. XM_054365619.1 → XP_054221594.1  fucose mutarotase isoform X1

  7. XM_054365623.1 → XP_054221598.1  fucose mutarotase isoform X5

  8. XM_054365624.1 → XP_054221599.1  fucose mutarotase isoform X6

  9. XM_054365626.1 → XP_054221601.1  fucose mutarotase isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VDF0.2 GenPept UniProtKB/Swiss-Prot:A2VDF0

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