U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

STK32C serine/threonine kinase 32C [ Homo sapiens (human) ]

Gene ID: 282974, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
STK32Cprovided by HGNC
Official Full Name
serine/threonine kinase 32Cprovided by HGNC
Primary source
HGNC:HGNC:21332
See related
Ensembl:ENSG00000165752 AllianceGenome:HGNC:21332
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKE; YANK3
Summary
The protein encoded by this gene is a member of the serine/threonine protein kinase family. It is thought that this family member is functional in brain due to its high expression levels there. DNA methylation differences have been found in this gene in monozygotic twins that are discordant for adolescent depression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Broad expression in brain (RPKM 5.0), testis (RPKM 3.2) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q26.3
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (132207482..132332235, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (133150298..133274880, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (134020986..134145384, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Janus kinase and microtubule interacting protein 3 Neighboring gene JAKMIP3 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134001171-134001672 Neighboring gene dihydropyrimidinase like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134056390-134057274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134067757-134068258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134068259-134068758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134078043-134078543 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134096746-134097345 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134111356-134111519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2953 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122180-134122724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134122725-134123267 Neighboring gene Sharpr-MPRA regulatory region 5064 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4223 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:134144980-134145514 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4224 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:134152941-134153095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134166187-134167149 Neighboring gene leucine rich repeat containing 27 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134203032-134203711 Neighboring gene uncharacterized LOC124902526 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134208622-134209145 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134209146-134209668 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2958 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2959 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211239-134211761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134211762-134212284 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134214271-134215047 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134218733-134219360 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221245-134221872 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134221873-134222500 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:134222501-134223127 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:134227291-134227958 Neighboring gene PWWP domain containing 2B

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression. Sun E, et al. Cancer Biol Ther, 2019. PMID 30359551, Free PMC Article
  2. Genome-wide methylomic analysis of monozygotic twins discordant for adolescent depression. Dempster EL, et al. Biol Psychiatry, 2014 Dec 15. PMID 24929637, Free PMC Article
  3. Replication of recently described type 2 diabetes gene variants in a South Indian population. Chidambaram M, et al. Metabolism, 2010 Dec. PMID 20580033
  4. The protein kinase complement of the human genome. Manning G, et al. Science, 2002 Dec 6. PMID 12471243
  5. Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107413

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Silencing of STK32C inhibited the activity of the HMGB1 pathway and regulated the expression of key genes in this pathway.
    Title: Serine/threonine kinase 32C is overexpressed in bladder cancer and contributes to tumor progression.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Replication of recently described type 2 diabetes gene variants in a South Indian population.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC23665

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
serine/threonine-protein kinase 32C
Names
PKE protein kinase
testicular tissue protein Li 187
yet another novel kinase 3
NP_001305807.1
NP_001305808.1
NP_001305809.1
NP_001305810.1
NP_001305811.1
NP_001305812.1
NP_775846.2
XP_011537990.1
XP_011537992.1
XP_011537995.1
XP_011537996.1
XP_011537997.1
XP_016871589.1
XP_016871590.1
XP_024303715.2
XP_024303717.2
XP_047281068.1
XP_047281069.1
XP_047281070.1
XP_047281071.1
XP_054221615.1
XP_054221616.1
XP_054221617.1
XP_054221618.1
XP_054221619.1
XP_054221620.1
XP_054221621.1
XP_054221622.1
XP_054221623.1
XP_054221624.1
XP_054221625.1
XP_054221626.1
XP_054221627.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318878.2 → NP_001305807.1  serine/threonine-protein kinase 32C isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK302102, AL590105, CD369442, HY020713, HY070240
    UniProtKB/TrEMBL
    B7Z7J1, I6L972
    Conserved Domains (2) summary
    smart00220
    Location:106 → 361
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:105 → 366
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  2. NM_001318879.2 → NP_001305808.1  serine/threonine-protein kinase 32C isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK302102, BC045760, CD369442, HY018020
    Consensus CDS
    CCDS81525.1
    UniProtKB/TrEMBL
    I6L972
    Related
    ENSP00000357611.1, ENST00000368622.5
    Conserved Domains (1) summary
    cd05578
    Location:1 → 236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  3. NM_001318880.2 → NP_001305809.1  serine/threonine-protein kinase 32C isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AA782619, AL590105, CD674243, HY020713, HY070240
    Consensus CDS
    CCDS81527.1
    UniProtKB/TrEMBL
    H0Y431
    Related
    ENSP00000389112.2, ENST00000456004.1

  4. NM_001318881.2 → NP_001305810.1  serine/threonine-protein kinase 32C isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL590105, AW770528, BE009030, BF508609, DA574949, HY020713
    Consensus CDS
    CCDS81526.1
    UniProtKB/TrEMBL
    H0Y349
    Related
    ENSP00000357608.4, ENST00000368619.3

  5. NM_001318882.2 → NP_001305811.1  serine/threonine-protein kinase 32C isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) shares the 5' terminal exon but lacks the remaining exons found in variant 1, and instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AI911241, AL590105, BF508609, HY020713, HY106710, HY301367

  6. NM_001318883.2 → NP_001305812.1  serine/threonine-protein kinase 32C isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) uses an alternate splice site in the 5' terminal exon and lacks the remaining exons found in variant 1, but instead contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (g) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    AL590105, BF449072, BF508609, HY020713

  7. NM_173575.4 → NP_775846.2  serine/threonine-protein kinase 32C isoform b

    See identical proteins and their annotated locations for NP_775846.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK302102, AY098866, CD369442
    Consensus CDS
    CCDS7666.1
    UniProtKB/Swiss-Prot
    Q5T0Q5, Q86UE1, Q86UX6
    UniProtKB/TrEMBL
    A0A140VJW0, I6L972
    Related
    ENSP00000298630.3, ENST00000298630.8
    Conserved Domains (2) summary
    smart00220
    Location:93 → 348
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:92 → 353
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

RNA

  1. NR_134911.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) contains an alternate 5' terminal exon and includes an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, which results in an ORF that is in-frame with the coding region of variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK057849, AK302102, BM749615, CD369442
    Related
    ENST00000462160.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    132207482..132332235 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539693.3 → XP_011537995.1  serine/threonine-protein kinase 32C isoform X5

    See identical proteins and their annotated locations for XP_011537995.1

    UniProtKB/TrEMBL
    I6L972
    Conserved Domains (1) summary
    cd05578
    Location:1 → 236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  2. XM_011539688.2 → XP_011537990.1  serine/threonine-protein kinase 32C isoform X1

    Conserved Domains (2) summary
    smart00220
    Location:106 → 366
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:105 → 371
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  3. XM_011539690.3 → XP_011537992.1  serine/threonine-protein kinase 32C isoform X2

    UniProtKB/TrEMBL
    I6L972
    Conserved Domains (2) summary
    smart00220
    Location:93 → 353
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05578
    Location:92 → 358
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  4. XM_011539695.2 → XP_011537997.1  serine/threonine-protein kinase 32C isoform X5

    See identical proteins and their annotated locations for XP_011537997.1

    UniProtKB/TrEMBL
    I6L972
    Conserved Domains (1) summary
    cd05578
    Location:1 → 236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  5. XM_047425115.1 → XP_047281071.1  serine/threonine-protein kinase 32C isoform X5

  6. XM_047425114.1 → XP_047281070.1  serine/threonine-protein kinase 32C isoform X6

  7. XM_024447949.2 → XP_024303717.2  serine/threonine-protein kinase 32C isoform X7

  8. XM_011539694.2 → XP_011537996.1  serine/threonine-protein kinase 32C isoform X5

    See identical proteins and their annotated locations for XP_011537996.1

    UniProtKB/TrEMBL
    I6L972
    Conserved Domains (1) summary
    cd05578
    Location:1 → 236
    STKc_Yank1; Catalytic domain of the Serine/Threonine Kinase, Yank1

  9. XM_047425113.1 → XP_047281069.1  serine/threonine-protein kinase 32C isoform X4

  10. XM_047425112.1 → XP_047281068.1  serine/threonine-protein kinase 32C isoform X3

  11. XM_024447947.2 → XP_024303715.2  serine/threonine-protein kinase 32C isoform X8

    Related
    ENSP00000357609.3, ENST00000368620.2

  12. XM_017016101.2 → XP_016871590.1  serine/threonine-protein kinase 32C isoform X10

  13. XM_017016100.2 → XP_016871589.1  serine/threonine-protein kinase 32C isoform X9

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    133150298..133274880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365649.1 → XP_054221624.1  serine/threonine-protein kinase 32C isoform X5

  2. XM_054365640.1 → XP_054221615.1  serine/threonine-protein kinase 32C isoform X1

  3. XM_054365641.1 → XP_054221616.1  serine/threonine-protein kinase 32C isoform X2

  4. XM_054365644.1 → XP_054221619.1  serine/threonine-protein kinase 32C isoform X5

  5. XM_054365646.1 → XP_054221621.1  serine/threonine-protein kinase 32C isoform X5

  6. XM_054365645.1 → XP_054221620.1  serine/threonine-protein kinase 32C isoform X6

  7. XM_054365648.1 → XP_054221623.1  serine/threonine-protein kinase 32C isoform X7

  8. XM_054365647.1 → XP_054221622.1  serine/threonine-protein kinase 32C isoform X5

  9. XM_054365643.1 → XP_054221618.1  serine/threonine-protein kinase 32C isoform X4

  10. XM_054365642.1 → XP_054221617.1  serine/threonine-protein kinase 32C isoform X3

  11. XM_054365650.1 → XP_054221625.1  serine/threonine-protein kinase 32C isoform X8

  12. XM_054365652.1 → XP_054221627.1  serine/threonine-protein kinase 32C isoform X10

  13. XM_054365651.1 → XP_054221626.1  serine/threonine-protein kinase 32C isoform X9

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UX6.1 GenPept UniProtKB/Swiss-Prot:Q86UX6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous