NPBWR1 neuropeptides B and W receptor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NPBWR1provided by HGNC
Official Full Name: neuropeptides B and W receptor 1provided by HGNC
Primary source: HGNC:HGNC:4522
See related: Ensembl:ENSG00000288611 MIM:600730; AllianceGenome:HGNC:4522
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: GPR7
Summary: Predicted to enable G protein-coupled receptor activity and neuropeptide binding activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in neuron projection and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: mouse all
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Genomic context

Location:: 8q11.23

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (52939182..52943734)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (53315605..53320157)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (53851742..53856294)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

screening of GPR7 gene mutations among lean and obese subjects revealed a Tyr135Phe allelic variant that is fairly common in the study population. This variant is unlikely to cause a functional derangement of the receptor
Title: Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.
hypermethylation of HIST1H4F, PCDHGB6, NPBWR1, ALX1, and HOXA9 was significantly associated with shorter survival in stage 1 Non-small-cell lung cancer
Title: A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
A single nucleotide polymorphism of NPBWR1 changed the receptor function of this molecule at the cellular level, and, at the behavioral level, could influence personality difference in the context of social interaction.
Title: A single nucleotide polymorphism of the neuropeptide B/W receptor-1 gene influences the evaluation of facial expressions.
distribution in central nervous system and peripheral tissues with precursor peptides
Title: Identification of natural ligands for the orphan G protein-coupled receptors GPR7 and GPR8.
Expressed in the zona glomerulosa and zona fasciculata-reticularis ( cells of the human adrenal cortex.
Title: G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades.
neuropeptide B, a neuropeptide modified with bromine is an endogenous ligand for GPR7
Title: Identification of a neuropeptide modified with bromine as an endogenous ligand for GPR7.
methylation of the GPR7 is significantly associated with prostate cancer prognosis.
Title: Discovery and validation of 3 novel DNA methylation markers of prostate cancer prognosis.
These results suggest a relationship between the pathogenesis of inflammatory/immune-mediated neuropathies, GPR7 receptor expression, and pain transmission.
Title: Schwann cell overexpression of the GPR7 receptor in inflammatory and painful neuropathies.
characterization of a family of endogenous neuropeptide ligands for this G protein-coupled receptor
Title: Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH71213 (e-PCR)
- UniSTS:35724

NoName (e-PCR)
- UniSTS:481712

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled opioid receptor activity	TAS Traceable Author Statement more info	PubMed
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled opioid receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in chemical synaptic transmission	TAS Traceable Author Statement more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IC Inferred by Curator more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuropeptides B/W receptor type 1

Names: G-protein coupled receptor 7; neuropeptide B/W receptor 1; neuropeptides B/W receptor 1; opioid-somatostatin-like receptor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_005285.5 → NP_005276.2 neuropeptides B/W receptor type 1

See identical proteins and their annotated locations for NP_005276.2

Status: VALIDATED

Source sequence(s)

AC087348

Consensus CDS

CCDS6151.1

UniProtKB/Swiss-Prot

P48145, Q6NTC7

UniProtKB/TrEMBL

H9NIL7

Related

ENSP00000501711.1, ENST00000674939.1

Conserved Domains (1) summary

cd15087
Location:47 → 318

7tmA_NPBWR; neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors