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LINC00324 long intergenic non-protein coding RNA 324 [ Homo sapiens (human) ]

Gene ID: 284029, updated on 31-Mar-2024

Summary

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Official Symbol
LINC00324provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 324provided by HGNC
Primary source
HGNC:HGNC:26628
See related
Ensembl:ENSG00000178977 AllianceGenome:HGNC:26628
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C17orf44; RNA00324; TP53LC03; NCRNA00324
Expression
Ubiquitous expression in lymph node (RPKM 2.5), spleen (RPKM 2.2) and 24 other tissues See more
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Genomic context

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See LINC00324 in Genome Data Viewer
Location:
17p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (8220630..8224043, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (8126855..8130271, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (8123948..8127361, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11682 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11683 Neighboring gene nonconserved acetylation island sequence 72 enhancer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:8107017-8107517 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:8113125-8113784 Neighboring gene aurora kinase B Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr17:8124016-8124902 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11686 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8176 Neighboring gene tRNA-Trp (anticodon CCA) 1-1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11687 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8177 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:8126237-8126978 Neighboring gene tRNA-Gly (anticodon TCC) 3-1 Neighboring gene tRNA-Asp (anticodon GTC) 2-11 Neighboring gene tRNA-Pro (anticodon CGG) 1-3 Neighboring gene tRNA-Thr (anticodon AGT) 1-2 Neighboring gene tRNA-Ser (anticodon AGA) 2-6 Neighboring gene CST telomere replication complex component 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A concise review on the role of LINC00324 in different cancers. Ghafouri-Fard S, et al. Pathol Res Pract, 2022 Dec. PMID 36399929
  2. Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p. Xu J, et al. Aging (Albany NY), 2020 Dec 14. PMID 33318312, Free PMC Article
  3. Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway. Wan JF, et al. Eur Rev Med Pharmacol Sci, 2020 Jun. PMID 32633374
  4. Long intergenic non-protein coding RNA 324 prevents breast cancer progression by modulating miR-10b-5p. Wang B, et al. Aging (Albany NY), 2020 Apr 18. PMID 32305959, Free PMC Article
  5. [Correlation analysis between LINC00324 and immunophenotype in peripheral blood leukocytes in patients with acute myeloid leukemia]. Liu Y, et al. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2019 Sep. PMID 31750827

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
    Title: Dysregulation of LINC00324 promotes poor prognosis in patients with glioma.
  2. Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
    Title: Effect of lncRNA LINC00324 on cervical cancer progression through down-regulation of miR-195-5p.
  3. A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
    Title: A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression.
  4. LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
    Title: LINC00324 promotes cell proliferation and metastasis of esophageal squamous cell carcinoma through sponging miR-493-5p via MAPK signaling pathway.
  5. LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
    Title: LINC00324 suppresses apoptosis and autophagy in nasopharyngeal carcinoma through upregulation of PAD4 and activation of the PI3K/AKT signaling pathway.
  6. A concise review on the role of LINC00324 in different cancers.
    Title: A concise review on the role of LINC00324 in different cancers.
  7. LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
    Title: LncRNA LINC00324 is upregulated in intervertebral disk degeneration and upregulates FasL in nucleus pulposus cells.
  8. LINC00324 facilitates cell proliferation through competing for miR2145p in immature ovarian teratocarcinoma.
    Title: LINC00324 facilitates cell proliferation through competing for miR‑214‑5p in immature ovarian teratocarcinoma.
  9. Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
    Title: Suppression of long noncoding RNA LINC00324 restricts cell proliferation and invasion of papillary thyroid carcinoma through downregulation of TRIM29 via upregulating microRNA-195-5p.
  10. Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
    Title: Linc00324 promotes the progression of papillary thyroid cancer via regulating Notch signaling pathway.
Submit: New GeneRIF Correction See all GeneRIFs (17)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Clone Names

  • FLJ34790, MGC104931

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026951.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC135178, AK092109, BC089396
    Related
    ENST00000315707.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    8220630..8224043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    8126855..8130271 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173621.1: Suppressed sequence

    Description
    NM_173621.1: This RefSeq was permanently suppressed because currently there is support for the transcript, but not for the protein, and it is a candidate for nonsense-mediated decay.
Nucleotide Protein
Heading Accession and Version

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