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ZNF776 zinc finger protein 776 [ Homo sapiens (human) ]

Gene ID: 284309, updated on 2-Nov-2024

Summary

Official Symbol
ZNF776provided by HGNC
Official Full Name
zinc finger protein 776provided by HGNC
Primary source
HGNC:HGNC:26765
See related
Ensembl:ENSG00000152443 AllianceGenome:HGNC:26765
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 5.3), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF776 in Genome Data Viewer
Location:
19q13.43
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57746815..57758148)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60843753..60855084)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58258183..58269516)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904783 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58238691-58239191 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58239145-58239370 Neighboring gene zinc finger protein 671 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297126-58297745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297746-58298364 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58300764-58300910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58309809-58310356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15160 Neighboring gene Sharpr-MPRA regulatory region 649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58314953-58315566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene zinc finger protein 552

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Integrated Genome-wide Association, Coexpression Network, and Expression Single Nucleotide Polymorphism Analysis Identifies Novel Pathway in Allergic Rhinitis.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ30886, FLJ38288, DKFZp781G1213, DKFZp686K10134

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052796.1 RefSeqGene

    Range
    5020..16353
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001348007.2NP_001334936.1  zinc finger protein 776 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice structure in its 3' coding region, resulting in a translational frameshift and shorter 3' UTR, compared to variant 1. The encoded isoform (2) is substantially shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK127764, AK299680, BX105932, DA534001
    UniProtKB/Swiss-Prot
    Q68DI1
    UniProtKB/TrEMBL
    B4DSC6
    Conserved Domains (1) summary
    pfam01352
    Location:1354
    KRAB; KRAB box
  2. NM_173632.4NP_775903.3  zinc finger protein 776 isoform 1

    See identical proteins and their annotated locations for NP_775903.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI446541, AK127764, AK299680, BC136753, CR936802
    Consensus CDS
    CCDS12962.2
    UniProtKB/Swiss-Prot
    Q68DI1, Q6ZS36, Q8N968
    Related
    ENSP00000321812.5, ENST00000317178.10
    Conserved Domains (5) summary
    smart00349
    Location:1455
    KRAB; krueppel associated box
    COG5048
    Location:291439
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:322342
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1453
    KRAB; KRAB box
    pfam13465
    Location:390415
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_145326.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK127764, AK299680, BX105932, DA534001
  2. NR_145327.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon structure near its 3' end compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK127764, AK299680, BX105932, CR936802, DA534001
  3. NR_145328.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AK127764, BX105932, HY045891

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57746815..57758148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60843753..60855084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)