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LINC01270 long intergenic non-protein coding RNA 1270 [ Homo sapiens (human) ]

Gene ID: 284751, updated on 16-Apr-2024

Summary

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Official Symbol
LINC01270provided by HGNC
Official Full Name
long intergenic non-protein coding RNA 1270provided by HGNC
Primary source
HGNC:HGNC:27658
See related
Ensembl:ENSG00000203999 AllianceGenome:HGNC:27658
Gene type
ncRNA
RefSeq status
PREDICTED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in liver (RPKM 1.2), appendix (RPKM 1.0) and 21 other tissues See more
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Genomic context

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Location:
20q13.13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50292720..50314919)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52062422..52084536)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (48909257..48931456)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372656 Neighboring gene MPRA-validated peak4248 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891163-48891664 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48891665-48892164 Neighboring gene plaque enriched lncRNA in atherosclerotic and inflammatory bowel macrophage regulation Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48894009-48894546 Neighboring gene Sharpr-MPRA regulatory region 10045 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13019 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48908810-48909546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48910660-48911160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48921517-48922292 Neighboring gene Sharpr-MPRA regulatory region 5066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925071-48925582 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:48925583-48926093 Neighboring gene long intergenic non-protein coding RNA 1271 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48937461-48938045 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938046-48938631 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:48938632-48939216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18085 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18086 Neighboring gene uncharacterized LOC105372657 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48971862-48972074 Neighboring gene MPRA-validated peak4249 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:48990074-48990574 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:48995605-48996033 Neighboring gene uncharacterized LOC124904928

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation. Li N, et al. Cancer Gene Ther, 2021 May. PMID 33199829
  2. Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326. Zhang W, et al. Bioengineered, 2022 Jun. PMID 36694453, Free PMC Article
  3. LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis. Jiang B, et al. Bioengineered, 2022 Apr. PMID 35345980, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abnormal expression of long non-coding RNA LINC01270 in glioma and its correlation with X-ray computed tomography signs.
    Title: Abnormal expression of long non‑coding RNA LINC01270 in glioma and its correlation with X‑ray computed tomography signs.
  2. Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway.
    Title: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway.
  3. Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
    Title: Long non-coding RNA LINC01270 is an onco-promotor in lung adenocarcinoma by upregulating LARP1 via sponging miR-326.
  4. LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.
    Title: LncRNA LINC01270 aggravates the progression of gastric cancer through modulation of miR-326/EFNA3 axis.
  5. Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation.
    Title: Silencing of long non-coding RNA LINC01270 inhibits esophageal cancer progression and enhances chemosensitivity to 5-fluorouracil by mediating GSTP1methylation.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_034124.1 RNA Sequence

    Status: PREDICTED

    Source sequence(s)
    AK090605, AL354889
    Related
    ENST00000371639.8

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    50292720..50314919
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    52062422..52084536
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001025463.1: Suppressed sequence

    Description
    NM_001025463.1: This RefSeq was permanently suppressed because it contains repetitive sequence, is a nonsense-mediated mRNA decay (NMD) candidate and currently there is insufficient support for the protein.
Nucleotide Protein
Heading Accession and Version

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