U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C20orf203 chromosome 20 open reading frame 203 [ Homo sapiens (human) ]

Gene ID: 284805, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C20orf203provided by HGNC
Official Full Name
chromosome 20 open reading frame 203provided by HGNC
Primary source
HGNC:HGNC:26592
See related
Ensembl:ENSG00000198547 AllianceGenome:HGNC:26592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is thought to be a human-specific protein. Currently available evidence suggests that orthologous regions in other organisms contain sequence differences that would not support production of a protein product. Genome-wide association studies have suggested the possibility that a SNP in the 3' UTR, rs17123507, could be associated with nicotine addiction. Expression of this gene may be elevated in some individuals with Alzheimer's disease. [provided by RefSeq, Mar 2017]
Expression
Low expression observed in reference dataset See more
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
20q11.21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (32631625..32673941, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (34360296..34402612, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (31219427..31261743, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene nucleolar protein 4 like Neighboring gene uncharacterized LOC105372592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31124544-31125515 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31126487-31127458 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31128887-31129392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31129393-31129898 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31149672-31150323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31151241-31151782 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31158183-31158907 Neighboring gene Sharpr-MPRA regulatory region 4335 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31164325-31165278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31168247-31168946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12793 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12794 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12795 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12796 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12797 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12798 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12801 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17718 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12802 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31184984-31185484 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31185485-31185985 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31186003-31186504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31189553-31190054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12803 Neighboring gene NOL4L divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31193059-31193558 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31193901-31194067 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198315-31198930 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31198931-31199544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31206902-31207402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31211056-31211606 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31226763-31227262 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31226322-31226509 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235460-31235960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31235961-31236461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252264-31252832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31252833-31253400 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31254622-31255122 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31259991-31260490 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31263362-31264064 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31267024-31267622 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31266424-31267023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31267623-31268222 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr20:31268822-31269421 and GRCh37_chr20:31269422-31270020 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31271401-31271902 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31271903-31272402 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31274017-31274656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31277881-31278443 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:31290694-31291210 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31293307-31294054 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31296664-31297170 Neighboring gene Sharpr-MPRA regulatory region 13573 Neighboring gene BCL2 antagonist/killer 1 pseudogene 1 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31310141-31310642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:31310711-31311220 Neighboring gene COMM domain containing 7 Neighboring gene Sharpr-MPRA regulatory region 10337 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31320600-31321468 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31321469-31322336 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:31324911-31325766 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31326137-31326302 Neighboring gene OCT4 hESC enhancer GRCh37_chr20:31328938-31329439 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:31329890-31330064 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:31330109-31330936 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12806

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Genetic linkage to chromosome 22q12 for a heavy-smoking quantitative trait in two independent samples. Saccone SF, et al. Am J Hum Genet, 2007 May. PMID 17436240, Free PMC Article
  2. Molecular genetics of nicotine dependence and abstinence: whole genome association using 520,000 SNPs. Uhl GR, et al. BMC Genet, 2007 Apr 3. PMID 17407593, Free PMC Article
  3. Mapping and verification of susceptibility loci for smoking quantity using permutation linkage analysis. Wang D, et al. Pharmacogenomics J, 2005. PMID 15724146
  4. De novo origin of human protein-coding genes. Wu DD, et al. PLoS Genet, 2011 Nov. PMID 22102831, Free PMC Article
  5. A human-specific de novo protein-coding gene associated with human brain functions. Li CY, et al. PLoS Comput Biol, 2010 Mar 26. PMID 20376170, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ33706

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein C20orf203
Names
alugen

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_182584.4 → NP_872390.2  uncharacterized protein C20orf203

    See identical proteins and their annotated locations for NP_872390.2

    Status: VALIDATED

    Source sequence(s)
    BC105014, BM662904, FO393400, GU931819
    Consensus CDS
    CCDS13203.1
    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4
    Related
    ENSP00000495424.1, ENST00000608990.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    32631625..32673941 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440131.1 → XP_047296087.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4
    Related
    ENSP00000495162.1, ENST00000360785.6

  2. XM_024451878.2 → XP_024307646.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    34360296..34402612 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323396.1 → XP_054179371.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4

  2. XM_054323395.1 → XP_054179370.1  uncharacterized protein C20orf203 isoform X1

    UniProtKB/Swiss-Prot
    B8JHY2, Q8NBC4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_026959.1: Suppressed sequence

    Description
    NR_026959.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NBC4.2 GenPept UniProtKB/Swiss-Prot:Q8NBC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Miscellaneous