GPR26 G protein-coupled receptor 26 [Homo sapiens (human)] - Gene

Summary

Official Symbol: GPR26provided by HGNC
Official Full Name: G protein-coupled receptor 26provided by HGNC
Primary source: HGNC:HGNC:4481
See related: Ensembl:ENSG00000154478 MIM:604847; AllianceGenome:HGNC:4481
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene encodes a G protein-couple receptor protein. G-protein-coupled receptors are a large family of membrane proteins that are involved in cellular responses to environmental stimuli, neurotransmitters, and hormones. The encoded protein may play a role in neurodegenerative diseases. Epigenetic silencing of this gene has been observed in gliomas. [provided by RefSeq, Sep 2016]
Expression: Restricted expression toward brain (RPKM 2.1) See more
Orthologs: mouse all
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Genomic context

Location:: 10q26.13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	10	NC_000010.11 (123666355..123697399)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	10	NC_060934.1 (124543147..124574217)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	10	NC_000010.10 (125425871..125456915)

Chromosome 10 - NC_000010.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties.
Title: MiR-188-3p/GPR26 modulation functions as a potential regulator in manipulating glioma cell properties.
GPR26 may have a common role in the formation or degradation of intranuclear inclusions in several neurodegenerative diseases
Title: G protein-coupled receptor 26 immunoreactivity in intranuclear inclusions associated with polyglutamine and intranuclear inclusion body diseases.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
epigenetic silencing is a common mechanism in malignant gliomas that simultaneously inactivates MGMT and GPR26
Title: The 10q25.3-26.1 G protein-coupled receptor gene GPR26 is epigenetically silenced in human gliomas.
Study has identified GPR26 to be a genetic indicator of primary glioblastoma, suggesting that it could be a suppressor of primary glioblastoma development.
Title: GPR26: a marker for primary glioblastoma?

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:484618

Cda0gg11 (e-PCR)
- UniSTS:24102

SHGC-81866 (e-PCR)
- UniSTS:103985

D10S1383E (e-PCR)
- UniSTS:151379

G42192 (e-PCR)
- UniSTS:105110

SHGC-85225 (e-PCR)
- UniSTS:104361

NoName (e-PCR)
- UniSTS:481494

D10S1467 (e-PCR)
- UniSTS:66273

G20286 (e-PCR)
- UniSTS:35563

A005K29 (e-PCR)
- UniSTS:35564

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_051571.1 RefSeqGene

Range

5001..36045

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_153442.4 → NP_703143.1 G-protein coupled receptor 26

See identical proteins and their annotated locations for NP_703143.1

Status: REVIEWED

Source sequence(s)

AC009987, AI076749, AJ505757, AK091093

Consensus CDS

CCDS7636.1

UniProtKB/Swiss-Prot

Q2M2E2, Q8NDV2

Related

ENSP00000284674.1, ENST00000284674.2

Conserved Domains (1) summary

cd15219
Location:7 → 305

7tmA_GPR26_GPR78-like; G protein-coupled receptors 26 and 78, member of the class A family of seven-transmembrane G protein-coupled receptors