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TTC28-AS1 TTC28 antisense RNA 1 [ Homo sapiens (human) ]

Gene ID: 284900, updated on 10-Oct-2023

Summary

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Official Symbol
TTC28-AS1provided by HGNC
Official Full Name
TTC28 antisense RNA 1provided by HGNC
Primary source
HGNC:HGNC:29336
See related
Ensembl:ENSG00000235954 AllianceGenome:HGNC:29336
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TTC28AS; TTC28-AS; dJ353E16.2
Expression
Ubiquitous expression in ovary (RPKM 2.4), endometrium (RPKM 2.3) and 25 other tissues See more
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Genomic context

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Location:
22q12.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (27919376..28002679)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (28380792..28464100)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (28315364..28398667)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985529 Neighboring gene VISTA enhancer hs1271 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr22:28246273-28246791 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18802 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28314444-28315429 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28315430-28316414 Neighboring gene phosphatidylinositol transfer protein beta Neighboring gene microRNA 3199-1 Neighboring gene microRNA 3199-2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28376696-28377276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28388821-28389342 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:28389343-28389862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28391245-28391744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:28415419-28415960 Neighboring gene tetratricopeptide repeat domain 28 Neighboring gene RNA, 7SL, cytoplasmic 757, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr22:28508589-28509131 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr22:28532907-28533662 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr22:28604851-28606050 Neighboring gene small nucleolar RNA SNORD42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus. Mohamadi M, et al. Scand J Clin Lab Invest, 2019 Nov. PMID 31509021
  2. Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis. Zhang J, et al. Genes Genomics, 2021 Dec. PMID 34623609
  3. A genome-wide association study on obesity and obesity-related traits. Wang K, et al. PLoS One, 2011 Apr 28. PMID 21552555, Free PMC Article
  4. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. Hirosawa M, et al. DNA Res, 2001 Feb 28. PMID 11258795
  5. A genome annotation-driven approach to cloning the human ORFeome. Collins JE, et al. Genome Biol, 2004. PMID 15461802, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis.
    Title: Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis.
  2. TTC28-AS1 expression is positively correlated with low-density lipoprotein cholesterol in type 2 diabetes mellitus.
    Title: Deregulation of long noncoding RNA SNHG17 and TTC28-AS1 is associated with type 2 diabetes mellitus.
Submit: New GeneRIF Correction

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study on obesity and obesity-related traits.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • TTC28 antisense RNA (non-protein coding)
  • TTC28 antisense RNA 1 (non-protein coding)

Clone Names

  • KIAA1648

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_026962.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses the same first exon as variant 1 but has a distinct 3' splice pattern.
    Source sequence(s)
    BC016779, BQ018666, DA934139
    Related
    ENST00000437713.7

  2. NR_026963.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AL033538, AL832597, BU740789, DA934139, DB254752
    Related
    ENST00000454741.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    27919376..28002679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    28380792..28464100
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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