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NKIRAS1 NFKB inhibitor interacting Ras like 1 [ Homo sapiens (human) ]

Gene ID: 28512, updated on 5-Mar-2024

Summary

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Official Symbol
NKIRAS1provided by HGNC
Official Full Name
NFKB inhibitor interacting Ras like 1provided by HGNC
Primary source
HGNC:HGNC:17899
See related
Ensembl:ENSG00000197885 MIM:604496; AllianceGenome:HGNC:17899
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KBRAS1; kappaB-Ras1
Summary
Predicted to enable GTPase activating protein binding activity. Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including Ral protein signal transduction; lung alveolus development; and surfactant homeostasis. Located in cytosol and endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 15.3), testis (RPKM 11.7) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
3p24.2
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (23889951..23946562, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (23894728..23951314, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (23931442..23988053, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14141 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14142 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14143 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19601 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14144 Neighboring gene UBE2E1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19602 Neighboring gene ubiquitin conjugating enzyme E2 E1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19604 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19605 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23906443-23907202 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:23924271-23924855 Neighboring gene ADP ribosylation factor like GTPase 4A pseudogene 4 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:23958136-23959335 Neighboring gene uncharacterized LOC124909354 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:23987327-23987868 Neighboring gene ribosomal protein L15 Neighboring gene Sharpr-MPRA regulatory region 12700 Neighboring gene MPRA-validated peak4577 silencer Neighboring gene nuclear receptor subfamily 1 group D member 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:24023426-24023962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:24023963-24024497 Neighboring gene Sharpr-MPRA regulatory region 5785 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:24136149-24136737 Neighboring gene long intergenic non-protein coding RNA 691 Neighboring gene nucleophosmin 1 pseudogene 23

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Prognostic significance of kappaB-Ras1 expression in gliomas. Lin H, et al. Med Oncol, 2012 Jun. PMID 21302000
  2. Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas. Gerashchenko GV, et al. Exp Oncol, 2010 Jul. PMID 20693965
  3. Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated with loss of their methylation as well as with methylation of regulatory miRNA genes. Braga EA, et al. Biochemistry (Mosc), 2015 Apr. PMID 25869366
  4. [Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer]. Khodyrev DS, et al. Mol Biol (Mosk), 2012 Sep-Oct. PMID 23156677
  5. Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras. Chen Y, et al. Mol Cell Biol, 2004 Apr. PMID 15024091, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene.
    Title: A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene.
  2. It was demonstrated that elevated levels of mRNA for NKIRAS1 was significantly associated both with loss of methylation in NKIRAS1 CpG-islands and methylation in a number of miRNA genes.
    Title: Upregulation of RHOA and NKIRAS1 genes in lung tumors is associated with loss of their methylation as well as with methylation of regulatory miRNA genes.
  3. Significant correlation was found between alterations of methylation status of miR-34b/c, miR-193a and the expression level of NKIRAS1 target gene in the primary lung tumors.
    Title: [Methylation of some miRNA genes is involved in the regulation of their target genes RAR-beta2 and NKIRAS1 expression in lung cancer].
  4. Low kappaB-Ras1 expression is associated with gliomas.
    Title: Prognostic significance of kappaB-Ras1 expression in gliomas.
  5. It was shown the decreased expression level of NKIRAS1 in Renal cell carcinoma
    Title: Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic and epigenetic changes of NKIRAS1 gene in human renal cell carcinomas.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activating protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in Ral protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lung alveolus development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of tumor necrosis factor-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in surfactant homeostasis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
NF-kappa-B inhibitor-interacting Ras-like protein 1
Names
I-kappa-B-interacting Ras-like protein 1
NFKB inhibitor interacting Ras-like protein 1
kappa B-Ras protein 1
kappa B-ras 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001377351.1 → NP_001364280.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914, DA116722
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000394214.2, ENST00000416026.2
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001377352.1 → NP_001364281.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. NM_001377353.1 → NP_001364282.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000373411.3, ENST00000388759.7
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_001377354.1 → NP_001364283.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  5. NM_001377355.1 → NP_001364284.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  6. NM_001377356.1 → NP_001364285.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  7. NM_001377357.1 → NP_001364286.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  8. NM_001377358.1 → NP_001364287.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  9. NM_001377359.1 → NP_001364288.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  10. NM_001377360.1 → NP_001364289.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  11. NM_001377361.1 → NP_001364290.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  12. NM_001377362.1 → NP_001364291.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  13. NM_001377363.1 → NP_001364292.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000483749.1, ENST00000614374.4
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  14. NM_001377364.1 → NP_001364293.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  15. NM_001377365.1 → NP_001364294.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  16. NM_001377366.1 → NP_001364295.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  17. NM_001377367.1 → NP_001364296.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  18. NM_001377368.1 → NP_001364297.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  19. NM_001377369.1 → NP_001364298.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 111
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  20. NM_001377370.1 → NP_001364299.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  21. NM_001377371.1 → NP_001364300.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  22. NM_001377372.1 → NP_001364301.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Conserved Domains (1) summary
    cl38936
    Location:6 → 136
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  23. NM_001377380.1 → NP_001364309.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC124914
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000392307.2, ENST00000421515.6
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  24. NM_020345.4 → NP_065078.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_065078.1

    Status: VALIDATED

    Source sequence(s)
    AC124914, BC012145, BG713995
    Consensus CDS
    CCDS33717.1
    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000400385.2, ENST00000425478.7
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    23889951..23946562 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047447998.1 → XP_047303954.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0

  2. XM_047447999.1 → XP_047303955.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0

  3. XM_024453460.2 → XP_024309228.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
    Related
    ENSP00000393785.2, ENST00000443659.6
    Conserved Domains (1) summary
    cl38936
    Location:6 → 168
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    23894728..23951314 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346244.1 → XP_054202219.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0

  2. XM_054346245.1 → XP_054202220.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0

  3. XM_054346246.1 → XP_054202221.1  NF-kappa-B inhibitor-interacting Ras-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q96K18, Q9NYS0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NYS0.1 GenPept UniProtKB/Swiss-Prot:Q9NYS0

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