U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ZNF775 zinc finger protein 775 [ Homo sapiens (human) ]

Gene ID: 285971, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
ZNF775provided by HGNC
Official Full Name
zinc finger protein 775provided by HGNC
Primary source
HGNC:HGNC:28501
See related
Ensembl:ENSG00000196456 AllianceGenome:HGNC:28501
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 2.3), brain (RPKM 1.7) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ZNF775 in Genome Data Viewer
Location:
7q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150379330..150398630)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151557672..151576951)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150076419..150095718)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107986858 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:150044724-150044956 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18775 Neighboring gene REPIN1 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150065484-150066288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150066289-150067094 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150067095-150067899 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26825 Neighboring gene replication initiator 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150078931-150079888 Neighboring gene ZNF775 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150080845-150081800 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083270-150083842 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150083843-150084413 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150085648-150086246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096281-150096868 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150096869-150097456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150097787-150098311 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150098312-150098835 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:150098842-150099517 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150099518-150100192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150100193-150100867 Neighboring gene zinc finger domain-containing protein LOC728743 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18779 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150103235-150103743 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26828 Neighboring gene uncharacterized LOC124901773 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18780

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. DCAF8, a novel MuRF1 interaction partner, promotes muscle atrophy. Nowak M, et al. J Cell Sci, 2019 Sep 6. PMID 31391242
  2. E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins. Khanna R, et al. FEBS J, 2018 Jun. PMID 29676528
  3. A directed protein interaction network for investigating intracellular signal transduction. Vinayagam A, et al. Sci Signal, 2011 Sep 6. PMID 21900206
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Olsen JV, et al. Cell, 2006 Nov 3. PMID 17081983
  5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC33584

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 775

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173680.4 → NP_775951.2  zinc finger protein 775

    See identical proteins and their annotated locations for NP_775951.2

    Status: VALIDATED

    Source sequence(s)
    AC073111, AW402889, BC015152, DB472309
    Consensus CDS
    CCDS43678.1
    UniProtKB/Swiss-Prot
    Q8IY24, Q96BV0
    Related
    ENSP00000330838.5, ENST00000329630.10
    Conserved Domains (3) summary
    COG5048
    Location:275 → 524
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:448 → 468
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:121 → 146
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    150379330..150398630
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420221.1 → XP_047276177.1  zinc finger protein 775 isoform X1

  2. XM_047420224.1 → XP_047276180.1  zinc finger protein 775 isoform X2

    UniProtKB/Swiss-Prot
    Q8IY24, Q96BV0

  3. XM_047420222.1 → XP_047276178.1  zinc finger protein 775 isoform X1

  4. XM_047420223.1 → XP_047276179.1  zinc finger protein 775 isoform X1

  5. XM_047420220.1 → XP_047276176.1  zinc finger protein 775 isoform X1

  6. XM_047420225.1 → XP_047276181.1  zinc finger protein 775 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    151557672..151576951
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357930.1 → XP_054213905.1  zinc finger protein 775 isoform X1

  2. XM_054357931.1 → XP_054213906.1  zinc finger protein 775 isoform X1

  3. XM_054357932.1 → XP_054213907.1  zinc finger protein 775 isoform X1

  4. XM_054357933.1 → XP_054213908.1  zinc finger protein 775 isoform X2

  5. XM_054357934.1 → XP_054213909.1  zinc finger protein 775 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96BV0.2 GenPept UniProtKB/Swiss-Prot:Q96BV0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous