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ZNF789 zinc finger protein 789 [ Homo sapiens (human) ]

Gene ID: 285989, updated on 3-Apr-2024

Summary

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Official Symbol
ZNF789provided by HGNC
Official Full Name
zinc finger protein 789provided by HGNC
Primary source
HGNC:HGNC:27801
See related
Ensembl:ENSG00000198556 AllianceGenome:HGNC:27801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 3.7), testis (RPKM 2.8) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
7q22.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (99472890..99487605)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (100711703..100726513)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99070513..99085228)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATP5MF-PTCD1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99058948-99059448 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99062959-99063576 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99063577-99064192 Neighboring gene ATP synthase membrane subunit f Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26317 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26318 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26319 Neighboring gene tRNA-Trp (anticodon CCA) 5-1 Neighboring gene zinc finger protein 394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99096344-99097012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26321 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26322 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26323 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99106467-99106660 Neighboring gene zinc finger with KRAB and SCAN domains 5 Neighboring gene zinc finger protein 3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. DNA methylation predicts the outcome of COVID-19 patients with acute respiratory distress syndrome. Bradic M, et al. J Transl Med, 2022 Nov 12. PMID 36371196, Free PMC Article
  2. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
  3. Human chromosome 7: DNA sequence and biology. Scherer SW, et al. Science, 2003 May 2. PMID 12690205, Free PMC Article
  4. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674
  5. High-throughput analyses of hnRNP H1 dissects its multi-functional aspect. Uren PJ, et al. RNA Biol, 2016. PMID 26760575, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 789

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013258.2 → NP_001013276.1  zinc finger protein 789 isoform 2

    See identical proteins and their annotated locations for NP_001013276.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two 3' exons, but has an alternate 3' exon, as compared to variant 1. The encoded isoform 2 has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AC073063, AK093141, BC031249, BM840763
    Consensus CDS
    CCDS34694.1
    UniProtKB/TrEMBL
    F8WEN0
    Related
    ENSP00000369047.3, ENST00000379724.3
    Conserved Domains (1) summary
    pfam01352
    Location:10 → 50
    KRAB; KRAB box

  2. NM_001350999.2 → NP_001337928.1  zinc finger protein 789 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC073063
    Conserved Domains (3) summary
    smart00349
    Location:1 → 54
    KRAB; krueppel associated box
    COG5048
    Location:236 → 296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001351000.2 → NP_001337929.1  zinc finger protein 789 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC073063
    Conserved Domains (3) summary
    COG5048
    Location:215 → 275
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:221 → 241
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 51
    KRAB; KRAB box

  4. NM_001351001.2 → NP_001337930.1  zinc finger protein 789 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC073063
    UniProtKB/TrEMBL
    C9J3R7
    Conserved Domains (1) summary
    pfam01352
    Location:10 → 51
    KRAB; KRAB box

  5. NM_001351002.2 → NP_001337931.1  zinc finger protein 789 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
    Source sequence(s)
    AC073063
    Conserved Domains (2) summary
    COG5048
    Location:158 → 218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_001351004.2 → NP_001337933.1  zinc finger protein 789 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
    Source sequence(s)
    AC073063, AK309467
    Conserved Domains (2) summary
    COG5048
    Location:158 → 218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. NM_213603.3 → NP_998768.2  zinc finger protein 789 isoform 1

    See identical proteins and their annotated locations for NP_998768.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC073063, AK093141, BC089424, BI767175
    Consensus CDS
    CCDS34693.1
    UniProtKB/Swiss-Prot
    A4D282, A6NH61, Q5FWF6, Q6ZMZ9
    Related
    ENSP00000331927.5, ENST00000331410.10
    Conserved Domains (5) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG5048
    Location:283 → 420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:11 → 50
    KRAB; KRAB box
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_147001.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063

  2. NR_147002.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063, BC031249, CB140921

  3. NR_147003.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC073063, AK309467, BC031249
    Related
    ENST00000483089.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    99472890..99487605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047420230.1 → XP_047276186.1  zinc finger protein 789 isoform X4

  2. XM_024446725.2 → XP_024302493.1  zinc finger protein 789 isoform X4

    Conserved Domains (2) summary
    COG5048
    Location:158 → 218
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:164 → 184
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_047420229.1 → XP_047276185.1  zinc finger protein 789 isoform X3

  4. XM_017012022.2 → XP_016867511.1  zinc finger protein 789 isoform X3

    Conserved Domains (2) summary
    COG5048
    Location:236 → 296
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:242 → 262
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_047420226.1 → XP_047276182.1  zinc finger protein 789 isoform X2

  6. XM_047420227.1 → XP_047276183.1  zinc finger protein 789 isoform X2

  7. XM_017012018.2 → XP_016867507.1  zinc finger protein 789 isoform X1

    UniProtKB/Swiss-Prot
    A4D282, A6NH61, Q5FWF6, Q6ZMZ9
    Conserved Domains (5) summary
    smart00349
    Location:11 → 71
    KRAB; krueppel associated box
    COG5048
    Location:283 → 420
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:259 → 279
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:11 → 50
    KRAB; KRAB box
    pfam13465
    Location:271 → 296
    zf-H2C2_2; Zinc-finger double domain

  8. XM_047420231.1 → XP_047276187.1  zinc finger protein 789 isoform X5

  9. XM_047420228.1 → XP_047276184.1  zinc finger protein 789 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    100711703..100726513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357940.1 → XP_054213915.1  zinc finger protein 789 isoform X1

    UniProtKB/Swiss-Prot
    A4D282, A6NH61, Q5FWF6, Q6ZMZ9

  2. XM_054357947.1 → XP_054213922.1  zinc finger protein 789 isoform X5

  3. XM_054357945.1 → XP_054213920.1  zinc finger protein 789 isoform X4

  4. XM_054357943.1 → XP_054213918.1  zinc finger protein 789 isoform X3

  5. XM_054357944.1 → XP_054213919.1  zinc finger protein 789 isoform X3

  6. XM_054357941.1 → XP_054213916.1  zinc finger protein 789 isoform X2

  7. XM_054357946.1 → XP_054213921.1  zinc finger protein 789 isoform X4

  8. XM_054357942.1 → XP_054213917.1  zinc finger protein 789 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWF6.3 GenPept UniProtKB/Swiss-Prot:Q5FWF6

Gene LinkOut

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