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LURAP1L leucine rich adaptor protein 1 like [ Homo sapiens (human) ]

Gene ID: 286343, updated on 2-Nov-2024

Summary

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Official Symbol
LURAP1Lprovided by HGNC
Official Full Name
leucine rich adaptor protein 1 likeprovided by HGNC
Primary source
HGNC:HGNC:31452
See related
Ensembl:ENSG00000153714 MIM:616130; AllianceGenome:HGNC:31452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LRAP35b; bA3L8.2; C9orf150; HYST0841
Summary
Predicted to be involved in regulation of signal transduction. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 9.1), lung (RPKM 7.8) and 23 other tissues See more
Orthologs
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Genomic context

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See LURAP1L in Genome Data Viewer
Location:
9p23
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (12775020..12823060)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (12784296..12832387)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (12775019..12823059)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene LURAP1L antisense RNA 1 Neighboring gene tyrosinase related protein 1 Neighboring gene RNA, 7SL, cytoplasmic 849, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr9:12814001-12815200 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:12948228-12949066 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr9:12953525-12954183 Neighboring gene small nucleolar RNA, C/D box 137 Neighboring gene peroxiredoxin 1 pseudogene 1 Neighboring gene lupus La protein-like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:13037568-13038084

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Adaptor protein LRAP25 mediates myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) regulation of LIMK1 protein in lamellipodial F-actin dynamics. Lee ICJ, et al. J Biol Chem, 2014 Sep 26. PMID 25107909, Free PMC Article
  2. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Yamada S, et al. Oncogene, 2004 Aug 5. PMID 15221005
  3. Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis. Tomarev SI, et al. Invest Ophthalmol Vis Sci, 2003 Jun. PMID 12766061
  4. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. Thiébaut R, et al. PLoS One, 2016. PMID 27812135, Free PMC Article
  5. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38505, FLJ90271, MGC46502

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
leucine rich adaptor protein 1-like
Names
leucine repeat adaptor protein 35b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203403.2 → NP_981948.1  leucine rich adaptor protein 1-like

    Status: VALIDATED

    Source sequence(s)
    AK095824, BC036923, BE464662, BM739457, BX508229, CD678148
    Consensus CDS
    CCDS6473.1
    UniProtKB/Swiss-Prot
    Q5VZX7, Q8IV03, Q8N923, Q8NCG2
    Related
    ENSP00000321026.3, ENST00000319264.4
    Conserved Domains (1) summary
    pfam14854
    Location:83 → 193
    LURAP; Leucine rich adaptor protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    12775020..12823060
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005251443.4 → XP_005251500.1  leucine rich adaptor protein 1-like isoform X1

    Conserved Domains (1) summary
    pfam14854
    Location:83 → 105
    LURAP; Leucine rich adaptor protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    12784296..12832387
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362779.1 → XP_054218754.1  leucine rich adaptor protein 1-like isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IV03.3 GenPept UniProtKB/Swiss-Prot:Q8IV03

Gene LinkOut

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