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FFAR1 free fatty acid receptor 1 [ Homo sapiens (human) ]

Gene ID: 2864, updated on 2-Nov-2024

Summary

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Official Symbol
FFAR1provided by HGNC
Official Full Name
free fatty acid receptor 1provided by HGNC
Primary source
HGNC:HGNC:4498
See related
Ensembl:ENSG00000126266 MIM:603820; AllianceGenome:HGNC:4498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FFA1R; GPR40; GPCR40
Summary
This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for medium and long chain free fatty acids and may be involved in the metabolic regulation of insulin secretion. Polymorphisms in this gene may be associated with type 2 diabetes. [provided by RefSeq, Apr 2009]
Orthologs
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Genomic context

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See FFAR1 in Genome Data Viewer
Location:
19q13.12
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (35347902..35353864)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (37892634..37898598)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (35838805..35844766)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14466 Neighboring gene myelin associated glycoprotein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35795633-35796520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802349-35802850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35802851-35803350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14467 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14469 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14470 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:35824208-35824417 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14472 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14471 Neighboring gene CD22 molecule Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35831571-35832072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14473 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14474 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14475 Neighboring gene MPRA-validated peak3448 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14477 Neighboring gene microRNA 5196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:35843089-35843955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10525 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:35850683-35851210 Neighboring gene free fatty acid receptor 3 Neighboring gene G protein-coupled receptor 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of residues important for agonist recognition and activation in GPR40. Sum CS, et al. J Biol Chem, 2007 Oct 5. PMID 17699519
  2. Basal hypersecretion of glucagon and insulin from palmitate-exposed human islets depends on FFAR1 but not decreased somatostatin secretion. Kristinsson H, et al. Sci Rep, 2017 Jul 5. PMID 28680093, Free PMC Article
  3. [A New Pain Regulatory System via the Brain Long Chain Fatty Acid Receptor GPR40/FFA1 Signal]. Nakamoto K. Yakugaku Zasshi, 2017. PMID 28154332
  4. Investigation of the Binding Interaction of Fatty Acids with Human G Protein-Coupled Receptor 40 Using a Site-Specific Fluorescence Probe by Flow Cytometry. Ren XM, et al. Biochemistry, 2016 Apr 5. PMID 26974599
  5. Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1). Hara T, et al. Mol Pharmacol, 2009 Jan. PMID 18927207

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].
    Title: [The involvement of brain fatty acid-GPR40/FFAR1 signaling in the stress-induced chronic pain].
  2. Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
    Title: Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.
  3. GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.
    Title: GPR40 Activation Abolishes Diabetes-Induced Painful Neuropathy by Suppressing VEGF-A Expression.
  4. Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.
    Title: Mutation of putative phosphorylation sites in the free fatty acid receptor 1: Effects on signaling, receptor phosphorylation, and internalization.
  5. Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
    Title: Ginseng Gintonin Contains Ligands for GPR40 and GPR55.
  6. Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.
    Title: Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells.
  7. Metabolic and physiological role of FFAR1 (GPR40), FFAR4 (GPR120), FFAR3 (GPR41) and FFAR2 (GPR43) is REVIEWED.
    Title: Free Fatty Acid Receptors in Health and Disease.
  8. GPR40 represents an important regulator of airway barrier integrity and may be a promising therapeutic target for the treatment of airway diseases.
    Title: Pharmacological stimulation of G-protein coupled receptor 40 alleviates cytokine-induced epithelial barrier disruption in airway epithelial Calu-3 cells.
  9. Periodontal expression of GPR40 and CD36 was upregulated in patients with both metabolic syndrome and periodontitis
    Title: Upregulation of free fatty acid receptors in periodontal tissues of patients with metabolic syndrome and periodontitis.
  10. High GRP40 expression is associated with epileptic seizure.
    Title: GPR40 modulates epileptic seizure and NMDA receptor function.
Submit: New GeneRIF Correction See all GeneRIFs (66)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
 PubMed 
enables bioactive lipid receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables bioactive lipid receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glucose homeostasis IEA
Inferred from Electronic Annotation
more info
  
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ligand-gated ion channel signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of calcium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of insulin secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to fatty acid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
free fatty acid receptor 1
Names
G-protein coupled receptor 40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005303.3 → NP_005294.1  free fatty acid receptor 1

    See identical proteins and their annotated locations for NP_005294.1

    Status: REVIEWED

    Source sequence(s)
    KF511268, U62631
    Consensus CDS
    CCDS12458.1
    UniProtKB/Swiss-Prot
    O14842, Q0VAS2, Q4VBL4
    UniProtKB/TrEMBL
    Q0IJ71
    Related
    ENSP00000246553.2, ENST00000246553.4
    Conserved Domains (1) summary
    cd15169
    Location:6 → 289
    7tmA_FFAR1; free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    35347902..35353864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047438698.1 → XP_047294654.1  free fatty acid receptor 1 isoform X1

    UniProtKB/Swiss-Prot
    O14842, Q0VAS2, Q4VBL4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    37892634..37898598
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320732.1 → XP_054176707.1  free fatty acid receptor 1 isoform X1

    UniProtKB/TrEMBL
    A5Z1T7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14842.1 GenPept UniProtKB/Swiss-Prot:O14842

Gene LinkOut

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