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Wfdc2 WAP four-disulfide core domain 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286888, updated on 18-Sep-2024

Summary

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Official Symbol
Wfdc2provided by RGD
Official Full Name
WAP four-disulfide core domain 2provided by RGD
Primary source
RGD:628757
See related
EnsemblRapid:ENSRNOG00000014739 AllianceGenome:RGD:628757
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
re4
Summary
Predicted to enable aspartic-type endopeptidase inhibitor activity and serine-type endopeptidase inhibitor activity. Predicted to be involved in antibacterial humoral response and innate immune response. Predicted to be active in extracellular space. Orthologous to human WFDC2 (WAP four-disulfide core domain 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 937.9), Kidney (RPKM 317.0) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wfdc2 in Genome Data Viewer
Location:
3q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173706091..173735055)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (153286946..153314832)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (161018497..161045469)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120101784 Neighboring gene bolA family member 2, pseudogene 4 Neighboring gene serine peptidase inhibitor, Kunitz type, 3 Neighboring gene WAP four-disulfide core domain 6A Neighboring gene epididymal peptidase inhibitor Neighboring gene WAP four-disulfide core domain 8 Neighboring gene WAP four-disulfide core domain 6B Neighboring gene cytidine/uridine monophosphate kinase 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression. Rowswell-Turner RB, et al. J Immunol, 2021 May 15. PMID 33903172
  2. Human epididymis protein-4 (HE-4): a novel cross-class protease inhibitor. Chhikara N, et al. PLoS One, 2012. PMID 23139753, Free PMC Article
  3. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.
    Title: HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aspartic-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables aspartic-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in antibacterial humoral response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
WAP four-disulfide core domain protein 2
Names
epididymal secretory protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173109.2 → NP_775132.1  WAP four-disulfide core domain protein 2 precursor

    See identical proteins and their annotated locations for NP_775132.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    Q8CHN1, Q8CHN3
    UniProtKB/TrEMBL
    A0A8L2Q9W6, A6JX96
    Related
    ENSRNOP00000077787.2, ENSRNOT00000110333.2
    Conserved Domains (2) summary
    cd00199
    Location:121 → 167
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...
    pfam00095
    Location:32 → 73
    WAP; WAP-type (Whey Acidic Protein) 'four-disulfide core'

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    173706091..173735055
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104401.2 → XP_038960329.1  WAP four-disulfide core domain protein 2 isoform X2

    UniProtKB/TrEMBL
    A6JX97
    Related
    ENSRNOP00000032197.5, ENSRNOT00000039664.7
    Conserved Domains (1) summary
    cd00199
    Location:73 → 119
    WAP; whey acidic protein-type four-disulfide core domains. Members of the family include whey acidic protein, elafin (elastase-specific inhibitor), caltrin-like protein (a calcium transport inhibitor) and other extracellular proteinase inhibitors. A group of ...

  2. XM_063283178.1 → XP_063139248.1  WAP four-disulfide core domain protein 2 isoform X1

RNA

  1. XR_010064571.1 RNA Sequence

  2. XR_001837032.3 RNA Sequence

  3. XR_005501792.2 RNA Sequence

  4. XR_005501791.2 RNA Sequence

  5. XR_010064572.1 RNA Sequence

  6. XR_005501796.2 RNA Sequence

  7. XR_005501798.2 RNA Sequence

  8. XR_005501797.2 RNA Sequence

  9. XR_005501795.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CHN3.1 GenPept UniProtKB/Swiss-Prot:Q8CHN3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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