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Cyp4f5 cytochrome P450, family 4, subfamily f, polypeptide 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 286905, updated on 2-Nov-2024

Summary

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Symbol
Cyp4f5provided by RGD
Full Name
cytochrome P450, family 4, subfamily f, polypeptide 5provided by RGD
Primary source
RGD:708364
See related
EnsemblRapid:ENSRNOG00000042496 AllianceGenome:RGD:708364
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aromatase activity; heme binding activity; and iron ion binding activity. Involved in leukotriene metabolic process and response to 3-methylcholanthrene. Predicted to be located in endoplasmic reticulum membrane. Biomarker of congestive heart failure and hypertrophic cardiomyopathy. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 37.1), Thymus (RPKM 33.2) and 9 other tissues See more
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Genomic context

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See Cyp4f5 in Genome Data Viewer
Location:
7q11
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (12194567..12209495)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (11544040..11558982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (14559806..14574345)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479822 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 39 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 17 Neighboring gene cytochrome P450, family 4, subfamily f, polypeptide 37 Neighboring gene heterogeneous nuclear ribonucleoprotein A1-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Leukotriene B4 omega-side chain hydroxylation by CYP4F5 and CYP4F6. Bylund J, et al. Arch Biochem Biophys, 2003 Apr 1. PMID 12646265
  2. cDNA cloning of three new forms of rat brain cytochrome P450 belonging to the CYP4F subfamily. Kawashima H, et al. Biochem Biophys Res Commun, 1995 Dec 26. PMID 8554568
  3. Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats. Kalsotra A, et al. Biochem Biophys Res Commun, 2005 Dec 9. PMID 16182239
  4. Regulation of neuronal type genes in congestive heart failure rats. Andersson KB, et al. Acta Physiol (Oxf), 2006 Jan. PMID 16497176
  5. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. Aboutabl ME, et al. Br J Pharmacol, 2009 Dec. PMID 19889059, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in leukotriene metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to 3-methylcholanthrene IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in small molecule metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4F5
Names
CYPIVF5
cytochrome P450 4F5-like
NP_775147.1
XP_038934451.1
XP_038934453.1
XP_038934455.1
XP_063119147.1
XP_063119148.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173124.1 → NP_775147.1  cytochrome P450 4F5

    See identical proteins and their annotated locations for NP_775147.1

    Status: PROVISIONAL

    Source sequence(s)
    U39207
    UniProtKB/Swiss-Prot
    P51870
    UniProtKB/TrEMBL
    Q9EQ70
    Related
    ENSRNOP00000076271.3, ENSRNOT00000093545.3
    Conserved Domains (1) summary
    pfam00067
    Location:52 → 516
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    12194567..12209495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078523.2 → XP_038934451.1  cytochrome P450 4F5 isoform X1

    UniProtKB/TrEMBL
    A2VD07, A6K954, F7FNW8, Q9EQ70
    Conserved Domains (1) summary
    cd20679
    Location:74 → 517
    CYP4F; cytochrome P450 family 4, subfamily F

  2. XM_063263077.1 → XP_063119147.1  cytochrome P450 4F5 isoform X2

    Related
    ENSRNOP00000007428.3, ENSRNOT00000007428.8

  3. XM_063263078.1 → XP_063119148.1  cytochrome P450 4F5 isoform X3

  4. XM_039078525.2 → XP_038934453.1  cytochrome P450 4F5 isoform X3

    UniProtKB/TrEMBL
    A0A1W2Q6H4
    Conserved Domains (1) summary
    cl41757
    Location:1 → 344
    cytochrome_P450; cytochrome P450 (CYP) superfamily

  5. XM_039078527.2 → XP_038934455.1  cytochrome P450 4F5 isoform X4

    UniProtKB/TrEMBL
    A0A1W2Q6H4
    Conserved Domains (1) summary
    cl41757
    Location:10 → 320
    cytochrome_P450; cytochrome P450 (CYP) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51870.1 GenPept UniProtKB/Swiss-Prot:P51870

Gene LinkOut

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