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Testin testin gene [ Rattus norvegicus (Norway rat) ]

Gene ID: 286916, updated on 29-Feb-2024

Summary

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Official Symbol
Testinprovided by RGD
Official Full Name
testin geneprovided by RGD
Primary source
RGD:708447
See related
Ensembl:ENSRNOG00000018028 AllianceGenome:RGD:708447
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in immune response and proteolysis involved in cellular protein catabolic process. Located in cell junction. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy. Orthologous to human CTSL (cathepsin L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 172.6), Adrenal (RPKM 12.1) and 1 other tissue See more
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Genomic context

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Location:
17p14
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (3829012..3864995)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (3824222..3859385)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (4194796..4225376)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene trophoblast specific protein alpha Neighboring gene cytotoxic T lymphocyte-associated protein 2 alpha Neighboring gene thioredoxin-related transmembrane protein 3, pseudogene 1 Neighboring gene cathepsin L-like 3 Neighboring gene cathepsin 7 like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Testins are structurally related to the mouse cysteine proteinase precursor but devoid of any protease/anti-protease activity. Cheng CY, et al. Biochem Biophys Res Commun, 1993 Feb 26. PMID 8447824
  2. Rat testin is a newly identified component of the junctional complexes in various tissues whose mRNA is predominantly expressed in the testis and ovary. Grima J, et al. Biol Reprod, 1995 Feb. PMID 7711203
  3. Testins are structurally related Sertoli cell proteins whose secretion is tightly coupled to the presence of germ cells. Cheng CY, et al. J Biol Chem, 1989 Dec 15. PMID 2592382
  4. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization. Su L, et al. J Cell Physiol, 2020 Sep. PMID 31975378
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
    Title: Testin regulates the blood-testis barrier via disturbing occludin/ZO-1 association and actin organization.
Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of apoptotic signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
testin-2
Names
CMB-23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173132.2 → NP_775155.1  testin-2 precursor

    See identical proteins and their annotated locations for NP_775155.1

    Status: PROVISIONAL

    Source sequence(s)
    U16858
    UniProtKB/Swiss-Prot
    P15242, P15243
    UniProtKB/TrEMBL
    A6KAF2
    Related
    ENSRNOP00000024467.1, ENSRNOT00000024467.3
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114 → 332
    Peptidase_C1; Papain family cysteine protease

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    3829012..3864995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095434.2 → XP_038951362.1  testin-2 isoform X1

    UniProtKB/Swiss-Prot
    P15242, P15243
    UniProtKB/TrEMBL
    A6KAF2
    Conserved Domains (2) summary
    smart00848
    Location:29 → 87
    Inhibitor_I29; Cathepsin propeptide inhibitor domain (I29)
    pfam00112
    Location:114 → 332
    Peptidase_C1; Papain family cysteine protease
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15242.2 GenPept UniProtKB/Swiss-Prot:P15242

Gene LinkOut

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