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Zfp598 zinc finger protein 598 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287119, updated on 2-Nov-2024

Summary

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Official Symbol
Zfp598provided by RGD
Official Full Name
zinc finger protein 598provided by RGD
Primary source
RGD:1304900
See related
EnsemblRapid:ENSRNOG00000012434 AllianceGenome:RGD:1304900
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ntrap; Znf598
Summary
Predicted to enable several functions, including ribosome binding activity; stalled ribosome sensor activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including protein ubiquitination; rescue of stalled ribosome; and ribosome-associated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol. Predicted to be active in cytosolic ribosome. Orthologous to human ZNF598 (zinc finger protein 598, E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Adrenal (RPKM 141.7), Liver (RPKM 84.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp598 in Genome Data Viewer
Location:
10q12
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14198763..14210773)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13694224..13706235)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14035114..14047100)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene NHERF family PDZ scaffold protein 2 Neighboring gene neuropeptide W Neighboring gene synaptogyrin 3 Neighboring gene growth factor, augmenter of liver regeneration

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers. Fu X, et al. Mol Biol Cell, 2010 Jan 1. PMID 19864463, Free PMC Article
  2. Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination. Juszkiewicz S, et al. Mol Cell, 2017 Feb 16. PMID 28065601, Free PMC Article
  3. ZNF598 and RACK1 Regulate Mammalian Ribosome-Associated Quality Control Function by Mediating Regulatory 40S Ribosomal Ubiquitylation. Sundaramoorthy E, et al. Mol Cell, 2017 Feb 16. PMID 28132843, Free PMC Article
  4. Sequential Elution Interactome Analysis of the Mind Bomb 1 Ubiquitin Ligase Reveals a Novel Role in Dendritic Spine Outgrowth. Mertz J, et al. Mol Cell Proteomics, 2015 Jul. PMID 25931508, Free PMC Article
  5. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. NTRAP regulates retrograde neurotrophic signaling by controlling the formation of signaling endosomes.
    Title: Retrograde neurotrophic signaling requires a protein interacting with receptor tyrosine kinases via C2H2 zinc fingers.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-RNA adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
  
enables stalled ribosome sensor activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein monoubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in rescue of stalled ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rescue of stalled ribosome ISO
Inferred from Sequence Orthology
more info
  
involved_in ribosome-associated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 598

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105770.1 → NP_001099240.1  zinc finger protein 598

    See identical proteins and their annotated locations for NP_001099240.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HCV0
    Conserved Domains (1) summary
    COG5236
    Location:26 → 335
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14198763..14210773
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085356.2 → XP_038941284.1  zinc finger protein 598 isoform X1

    Conserved Domains (2) summary
    COG5236
    Location:26 → 325
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    PRK12323
    Location:393 → 622
    PRK12323; DNA polymerase III subunit gamma/tau

  2. XM_039085357.2 → XP_038941285.1  zinc finger protein 598 isoform X2

    Conserved Domains (2) summary
    COG5236
    Location:26 → 335
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    PRK12323
    Location:390 → 619
    PRK12323; DNA polymerase III subunit gamma/tau

  3. XM_006245934.5 → XP_006245996.1  zinc finger protein 598 isoform X3

    UniProtKB/TrEMBL
    D3ZR64
    Related
    ENSRNOP00000060223.3, ENSRNOT00000065827.4
    Conserved Domains (1) summary
    COG5236
    Location:26 → 325
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]

  4. XM_063268563.1 → XP_063124633.1  zinc finger protein 598 isoform X4

    Related
    ENSRNOP00000103560.1, ENSRNOT00000125633.1
Nucleotide Protein Strain
Heading Accession and Version

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