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Nubp2 NUBP iron-sulfur cluster assembly factor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287125, updated on 2-Nov-2024

Summary

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Official Symbol
Nubp2provided by RGD
Official Full Name
NUBP iron-sulfur cluster assembly factor 2provided by RGD
Primary source
RGD:1305113
See related
EnsemblRapid:ENSRNOG00000015090 AllianceGenome:RGD:1305113
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable iron-sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly. Predicted to be located in nucleus and spindle pole centrosome. Predicted to be active in cytosol. Orthologous to human NUBP2 (NUBP iron-sulfur cluster assembly factor 2, cytosolic). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 236.4), Thymus (RPKM 208.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nubp2 in Genome Data Viewer
Location:
10q12
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (14407743..14411428, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (13903224..13906928, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (14244201..14247930, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transfer RNA proline (anticodon AGG) 67 Neighboring gene hydroxyacyl glutathione hydrolase Neighboring gene insulin-like growth factor binding protein, acid labile subunit Neighboring gene splA/ryanodine receptor domain and SOCS box containing 3 Neighboring gene essential meiotic structure-specific endonuclease subunit 2 Neighboring gene mitochondrial ribosomal protein S34

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Motor protein KIFC5A interacts with Nubp1 and Nubp2, and is implicated in the regulation of centrosome duplication. Christodoulou A, et al. J Cell Sci, 2006 May 15. PMID 16638812
  2. Biogenesis of cytosolic and nuclear iron-sulfur proteins and their role in genome stability. Paul VD, et al. Biochim Biophys Acta, 2015 Jun. PMID 25583461
  3. Iron-sulfur cluster biogenesis in mammalian cells: New insights into the molecular mechanisms of cluster delivery. Maio N, et al. Biochim Biophys Acta, 2015 Jun. PMID 25245479, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent FeS chaperone activity IEA
Inferred from Electronic Annotation
more info
  
enables iron-sulfur cluster binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in iron-sulfur cluster assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in iron-sulfur cluster assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cytosolic Fe-S cluster assembly factor NUBP2
Names
NBP 2
nucleotide binding protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001011891.1 → NP_001011891.1  cytosolic Fe-S cluster assembly factor NUBP2

    See identical proteins and their annotated locations for NP_001011891.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079386
    UniProtKB/Swiss-Prot
    Q68FS1
    UniProtKB/TrEMBL
    A0A8I5ZU76, A6HCY0
    Related
    ENSRNOP00000083949.2, ENSRNOT00000120075.2
    Conserved Domains (2) summary
    COG0455
    Location:15 → 263
    FlhG; MinD-like ATPase involved in chromosome partitioning or flagellar assembly [Cell cycle control, cell division, chromosome partitioning, Cell motility]
    pfam10609
    Location:12 → 263
    ParA; NUBPL iron-transfer P-loop NTPase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    14407743..14411428 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008767558.4 → XP_008765780.1  cytosolic Fe-S cluster assembly factor NUBP2 isoform X1

    Conserved Domains (2) summary
    COG0489
    Location:13 → 172
    Mrp; Chromosome partitioning ATPase, Mrp family, contains Fe-S cluster [Cell cycle control, cell division, chromosome partitioning]
    cl21455
    Location:1 → 203
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q68FS1.1 GenPept UniProtKB/Swiss-Prot:Q68FS1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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