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Rars1 arginyl-tRNA synthetase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287191, updated on 2-Nov-2024

Summary

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Official Symbol
Rars1provided by RGD
Official Full Name
arginyl-tRNA synthetase 1provided by RGD
Primary source
RGD:1309215
See related
EnsemblRapid:ENSRNOG00000007739 AllianceGenome:RGD:1309215
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rars
Summary
Enables anion binding activity; arginine-tRNA ligase activity; and tRNA binding activity. Involved in arginyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 9. Orthologous to human RARS1 (arginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Muscle (RPKM 255.7), Thymus (RPKM 227.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rars1 in Genome Data Viewer
Location:
10q12
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (20774804..20799251, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (20270744..20295192, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (20633630..20658074, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microRNA 103a-1 Neighboring gene pantothenate kinase 3 Neighboring gene uncharacterized LOC134480662 Neighboring gene fibrillarin-like 1 Neighboring gene WW and C2 domain containing 1 Neighboring gene teneurin transmembrane protein 2 Neighboring gene uncharacterized LOC108352202

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of arginyl-tRNA synthetase in rats with focal cerebral ischemia. Fu R, et al. J Huazhong Univ Sci Technolog Med Sci, 2014 Apr. PMID 24710927
  2. Physical and biochemical characterization of a purified arginyl-tRNA synthetase-lysyl-tRNA-synthetase complex from rat liver. Van Dang C, et al. Biochemistry, 1982 Apr 13. PMID 7082655
  3. Structure of the ArgRS-GlnRS-AIMP1 complex and its implications for mammalian translation. Fu Y, et al. Proc Natl Acad Sci U S A, 2014 Oct 21. PMID 25288775, Free PMC Article
  4. LysRS serves as a key signaling molecule in the immune response by regulating gene expression. Yannay-Cohen N, et al. Mol Cell, 2009 Jun 12. PMID 19524539
  5. Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis. Ko YG, et al. J Cell Biol, 2000 May 1. PMID 10791971, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arginine-tRNA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables arginine-tRNA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arginyl-tRNA aminoacylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in arginyl-tRNA aminoacylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of aminoacyl-tRNA synthetase multienzyme complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
arginine--tRNA ligase, cytoplasmic
Names
argRS
arginyl-tRNA synthetase, cytoplasmic
NP_001099247.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105777.2 → NP_001099247.2  arginine--tRNA ligase, cytoplasmic

    See identical proteins and their annotated locations for NP_001099247.2

    Status: VALIDATED

    Source sequence(s)
    BF420005, CB313613, CF110623
    UniProtKB/Swiss-Prot
    B1WBX8, P40329
    UniProtKB/TrEMBL
    A6HDJ0
    Related
    ENSRNOP00000010252.4, ENSRNOT00000010252.8
    Conserved Domains (4) summary
    cd00671
    Location:193 → 457
    ArgRS_core; catalytic core domain of arginyl-tRNA synthetases
    smart01016
    Location:79 → 166
    Arg_tRNA_synt_N; Arginyl tRNA synthetase N terminal dom
    PLN02286
    Location:80 → 660
    PLN02286; arginine-tRNA ligase
    cl12020
    Location:498 → 660
    Anticodon_Ia_like; Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    20774804..20799251 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40329.2 GenPept UniProtKB/Swiss-Prot:P40329

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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