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Clk4 CDC-like kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287269, updated on 10-Jul-2024

Summary

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Official Symbol
Clk4provided by RGD
Official Full Name
CDC-like kinase 4provided by RGD
Primary source
RGD:1310274
See related
EnsemblRapid:ENSRNOG00000003714 AllianceGenome:RGD:1310274
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in regulation of RNA splicing. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and protein autophosphorylation. Predicted to be located in nucleus. Orthologous to human CLK4 (CDC like kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 235.7), Thymus (RPKM 232.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Clk4 in Genome Data Viewer
Location:
10q22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (36024364..36042366)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (35523382..35541387)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (36715565..36733473)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Myb/SANT DNA binding domain containing 5 like 1 Neighboring gene putative uncharacterized protein MSANTD5 Neighboring gene Myb/SANT DNA binding domain containing 5 Neighboring gene collagen type XXIII alpha 1 chain Neighboring gene uncharacterized LOC120095095 Neighboring gene uncharacterized LOC134480786

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells. Eisenreich A, et al. Circ Res, 2009 Mar 13. PMID 19168442
  2. Characterization and comparison of four serine- and arginine-rich (SR) protein kinases. Nayler O, et al. Biochem J, 1997 Sep 15. PMID 9307018, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of RNA splicing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
dual specificity protein kinase CLK4
NP_001013059.1
NP_001386357.1
NP_001386358.1
XP_006246299.1
XP_008765894.1
XP_038941309.1
XP_038941310.1
XP_038941311.1
XP_063124653.1
XP_063124654.1
XP_063124655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013041.1 → NP_001013059.1  dual specificity protein kinase CLK4 isoform 3

    See identical proteins and their annotated locations for NP_001013059.1

    Status: VALIDATED

    Source sequence(s)
    BC079006
    UniProtKB/TrEMBL
    A6HE53, Q6AYK7
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001399428.1 → NP_001386357.1  dual specificity protein kinase CLK4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZNT1, A6HE48
    Related
    ENSRNOP00000079861.1, ENSRNOT00000119764.2
    Conserved Domains (1) summary
    cd14213
    Location:146 → 475
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  3. NM_001399429.1 → NP_001386358.1  dual specificity protein kinase CLK4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A6HE49, F7ETQ4
    Related
    ENSRNOP00000103479.1, ENSRNOT00000132107.1
    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    36024364..36042366
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268583.1 → XP_063124653.1  dual specificity protein kinase CLK4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNT1, A6HE48

  2. XM_039085382.2 → XP_038941310.1  dual specificity protein kinase CLK4 isoform X1

    Related
    ENSRNOP00000005048.7, ENSRNOT00000005048.7
    Conserved Domains (1) summary
    cd14213
    Location:172 → 501
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  3. XM_039085381.2 → XP_038941309.1  dual specificity protein kinase CLK4 isoform X1

    Conserved Domains (1) summary
    cd14213
    Location:172 → 501
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  4. XM_063268585.1 → XP_063124655.1  dual specificity protein kinase CLK4 isoform X5

  5. XM_006246237.4 → XP_006246299.1  dual specificity protein kinase CLK4 isoform X3

    See identical proteins and their annotated locations for XP_006246299.1

    UniProtKB/TrEMBL
    A6HE49, F7ETQ4
    Related
    ENSRNOP00000106785.1, ENSRNOT00000162431.1
    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4

  6. XM_063268584.1 → XP_063124654.1  dual specificity protein kinase CLK4 isoform X4

    UniProtKB/TrEMBL
    A6HE53, Q6AYK7

  7. XM_039085383.2 → XP_038941311.1  dual specificity protein kinase CLK4 isoform X4

    UniProtKB/TrEMBL
    A6HE53, Q6AYK7
    Conserved Domains (1) summary
    cl21453
    Location:1 → 295
    PKc_like; Protein Kinases, catalytic domain

  8. XM_008767672.4 → XP_008765894.1  dual specificity protein kinase CLK4 isoform X3

    See identical proteins and their annotated locations for XP_008765894.1

    UniProtKB/TrEMBL
    A6HE49, F7ETQ4
    Conserved Domains (1) summary
    cd14213
    Location:110 → 439
    PKc_CLK1_4; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4
Nucleotide Protein Strain
Heading Accession and Version

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