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Mrpl22 mitochondrial ribosomal protein L22 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287302, updated on 2-Nov-2024

Summary

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Official Symbol
Mrpl22provided by RGD
Official Full Name
mitochondrial ribosomal protein L22provided by RGD
Primary source
RGD:1309277
See related
EnsemblRapid:ENSRNOG00000027039 AllianceGenome:RGD:1309277
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Heart (RPKM 243.7), Kidney (RPKM 237.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mrpl22 in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (42843165..42856243)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (42345446..42355779)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (43601786..43612119)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480692 Neighboring gene transfer RNA serine (anticodon AGA) 43 Neighboring gene CCR4-NOT transcription complex, subunit 8 Neighboring gene gem (nuclear organelle) associated protein 5 Neighboring gene interferon gamma induced GTPase like 1 Neighboring gene uncharacterized LOC134480693

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mammalian mitochondrial ribosomal proteins. N-terminal amino acid sequencing, characterization, and identification of corresponding gene sequences. Goldschmidt-Reisin S, et al. J Biol Chem, 1998 Dec 25. PMID 9857009
  2. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
  3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
  4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of large ribosomal subunit IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL22m
Names
39S ribosomal protein L22, mitochondrial
L22mt
MRP-L22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105781.1 → NP_001099251.1  large ribosomal subunit protein uL22m precursor

    See identical proteins and their annotated locations for NP_001099251.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/Swiss-Prot
    P0C2C0
    UniProtKB/TrEMBL
    A0A8I6A4X1, A6HER4
    Conserved Domains (1) summary
    pfam00237
    Location:69 → 172
    Ribosomal_L22; Ribosomal protein L22p/L17e

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    42843165..42856243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268592.1 → XP_063124662.1  large ribosomal subunit protein uL22m isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHT3

  2. XM_063268593.1 → XP_063124663.1  large ribosomal subunit protein uL22m isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHT3
    Related
    ENSRNOP00000029336.5, ENSRNOT00000029238.7

  3. XM_063268594.1 → XP_063124664.1  large ribosomal subunit protein uL22m isoform X1

    UniProtKB/TrEMBL
    A0A0H2UHT3

  4. XM_063268595.1 → XP_063124665.1  large ribosomal subunit protein uL22m isoform X2

    UniProtKB/TrEMBL
    A6HER5
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C2C0.1 GenPept UniProtKB/Swiss-Prot:P0C2C0

Gene LinkOut

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