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Zfp496 zinc finger protein 496 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287361, updated on 28-Oct-2024

Summary

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Official Symbol
Zfp496provided by RGD
Official Full Name
zinc finger protein 496provided by RGD
Primary source
RGD:1304611
See related
EnsemblRapid:ENSRNOG00000003129 AllianceGenome:RGD:1304611
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Znf496; Zkscan17
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in positive regulation of DNA-templated transcription and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Orthologous to human ZNF496 (zinc finger protein 496). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Kidney (RPKM 81.4), Thymus (RPKM 75.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Zfp496 in Genome Data Viewer
Location:
10q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44768463..44787386, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44268923..44287795, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (45833259..45852130, complement)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ferritin light chain 1 pseudogene Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 8-like Neighboring gene ribosomal protein L18, pseudogene 6 Neighboring gene uncharacterized LOC134480800 Neighboring gene uncharacterized LOC134480694 Neighboring gene NLR family, pyrin domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nizp1 zinc finger protein localization is determined by SCAN-domain inclusion regulated through alternative splicing. Kahns S, et al. Biochim Biophys Acta, 2010 Aug. PMID 20538088
  2. Characterization of zinc finger protein 496 that interacts with Jumonji/Jarid2. Mysliwiec MR, et al. FEBS Lett, 2007 Jun 12. PMID 17521633, Free PMC Article
  3. Nizp1, a novel multitype zinc finger protein that interacts with the NSD1 histone lysine methyltransferase through a unique C2HR motif. Nielsen AL, et al. Mol Cell Biol, 2004 Jun. PMID 15169884, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 496
Names
zinc finger with KRAB and SCAN domains 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271396.1 → NP_001258325.1  zinc finger protein 496

    Status: VALIDATED

    Source sequence(s)
    FQ223523, JAXUCZ010000010
    UniProtKB/TrEMBL
    F1LVS9
    Related
    ENSRNOP00000055109.3, ENSRNOT00000058308.5
    Conserved Domains (7) summary
    cd07765
    Location:220 → 248
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:314 → 567
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:401 → 421
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:516 → 537
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:455 → 477
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:50 → 126
    SCAN; SCAN domain
    pfam13465
    Location:441 → 464
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44768463..44787386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246451.4 → XP_006246513.1  zinc finger protein 496 isoform X1

    See identical proteins and their annotated locations for XP_006246513.1

    Conserved Domains (7) summary
    cd07765
    Location:220 → 248
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:332 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:517 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:456 → 478
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:50 → 126
    SCAN; SCAN domain
    pfam13465
    Location:442 → 465
    zf-H2C2_2; Zinc-finger double domain

  2. XM_006246450.2 → XP_006246512.1  zinc finger protein 496 isoform X1

    See identical proteins and their annotated locations for XP_006246512.1

    Conserved Domains (7) summary
    cd07765
    Location:220 → 248
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:332 → 568
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:517 → 538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:456 → 478
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:50 → 126
    SCAN; SCAN domain
    pfam13465
    Location:442 → 465
    zf-H2C2_2; Zinc-finger double domain

  3. XM_039085391.2 → XP_038941319.1  zinc finger protein 496 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:312 → 548
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:497 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:30 → 104
    SCAN; SCAN domain
    cl02581
    Location:200 → 228
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. XM_063268605.1 → XP_063124675.1  zinc finger protein 496 isoform X2

    UniProtKB/TrEMBL
    F1LVS9

  5. XM_006246452.4 → XP_006246514.1  zinc finger protein 496 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:312 → 548
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:497 → 518
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:30 → 104
    SCAN; SCAN domain
    cl02581
    Location:200 → 228
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  6. XM_008767781.4 → XP_008766003.1  zinc finger protein 496 isoform X4

    Conserved Domains (5) summary
    cd07765
    Location:65 → 93
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:177 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:301 → 323
    zf-C2H2; Zinc finger, C2H2 type

  7. XM_063268607.1 → XP_063124677.1  zinc finger protein 496 isoform X5

  8. XM_039085392.2 → XP_038941320.1  zinc finger protein 496 isoform X4

    Conserved Domains (5) summary
    cd07765
    Location:65 → 93
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:177 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:301 → 323
    zf-C2H2; Zinc finger, C2H2 type

  9. XM_039085393.2 → XP_038941321.1  zinc finger protein 496 isoform X4

    Conserved Domains (5) summary
    cd07765
    Location:65 → 93
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:177 → 413
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:247 → 267
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:362 → 383
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:301 → 323
    zf-C2H2; Zinc finger, C2H2 type
Nucleotide Protein Strain
Heading Accession and Version

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