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Drc3 dynein regulatory complex subunit 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287371, updated on 28-Oct-2024

Summary

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Official Symbol
Drc3provided by RGD
Official Full Name
dynein regulatory complex subunit 3provided by RGD
Primary source
RGD:1309150
See related
EnsemblRapid:ENSRNOG00000021303 AllianceGenome:RGD:1309150
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Lrrc48; RGD1309150
Summary
Predicted to be located in axoneme and sperm flagellum. Predicted to be active in cilium. Orthologous to human DRC3 (dynein regulatory complex subunit 3). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Biased expression in Heart (RPKM 39.3), Testes (RPKM 36.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Drc3 in Genome Data Viewer
Location:
10q22
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (45620045..45698902)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (45149094..45200659)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46712021..46762276)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102549418 Neighboring gene retinoic acid induced 1 Neighboring gene sterol regulatory element binding transcription factor 1 Neighboring gene target of myb1 like 2 membrane trafficking protein Neighboring gene ATP synthase mitochondrial F1 complex assembly factor 2 Neighboring gene ribosomal protein S4, X-linked, pseudogene 6 Neighboring gene GID complex subunit 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss-of-Function GAS8 Mutations Cause Primary Ciliary Dyskinesia and Disrupt the Nexin-Dynein Regulatory Complex. Olbrich H, et al. Am J Hum Genet, 2015 Oct 1. PMID 26387594, Free PMC Article
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein regulatory complex subunit 3
Names
leucine rich repeat containing 48
leucine-rich repeat-containing protein 48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013857.1 → NP_001013879.1  dynein regulatory complex subunit 3

    See identical proteins and their annotated locations for NP_001013879.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083838
    UniProtKB/Swiss-Prot
    Q5XI54
    Conserved Domains (3) summary
    sd00031
    Location:48 → 66
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:65 → 105
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:66 → 121
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    45620045..45698902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268617.1 → XP_063124687.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54

  2. XM_063268614.1 → XP_063124684.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54

  3. XM_063268618.1 → XP_063124688.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54

  4. XM_063268619.1 → XP_063124689.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54

  5. XM_063268615.1 → XP_063124685.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54
    Related
    ENSRNOP00000111553.1, ENSRNOT00000158365.1

  6. XM_063268621.1 → XP_063124691.1  dynein regulatory complex subunit 3 isoform X3

  7. XM_063268622.1 → XP_063124692.1  dynein regulatory complex subunit 3 isoform X4

  8. XM_063268620.1 → XP_063124690.1  dynein regulatory complex subunit 3 isoform X2

    Related
    ENSRNOP00000038778.5, ENSRNOT00000032685.6

  9. XM_063268613.1 → XP_063124683.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54
    Related
    ENSRNOP00000100747.1, ENSRNOT00000151269.1

  10. XM_063268616.1 → XP_063124686.1  dynein regulatory complex subunit 3 isoform X1

    UniProtKB/Swiss-Prot
    Q5XI54
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI54.1 GenPept UniProtKB/Swiss-Prot:Q5XI54

Gene LinkOut

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