Txndc17 thioredoxin domain containing 17 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Txndc17provided by RGD
Official Full Name: thioredoxin domain containing 17provided by RGD
Primary source: RGD:1308868
See related: EnsemblRapid:ENSRNOG00000083034 AllianceGenome:RGD:1308868
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Txnl5
Summary: Predicted to enable peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Predicted to be involved in tumor necrosis factor-mediated signaling pathway. Predicted to be active in cytosol. Orthologous to human TXNDC17 (thioredoxin domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 425.6), Liver (RPKM 201.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (57331312..57334284)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (56832749..56835721)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (58776792..58779764)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables peroxidase activity	ISO Inferred from Sequence Orthology more info
enables protein-disulfide reductase (NAD(P)H) activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-disulfide reductase (NAD(P)H) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in tumor necrosis factor-mediated signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: thioredoxin domain-containing protein 17

Names: thioredoxin-like 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105805.2 → NP_001099275.1 thioredoxin domain-containing protein 17

See identical proteins and their annotated locations for NP_001099275.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

B0K010

Related

ENSRNOP00000109424.1, ENSRNOT00000166128.1

Conserved Domains (1) summary

cd02952
Location:4 → 121

TRP14_like; Human TRX-related protein 14 (TRP14)-like family; composed of proteins similar to TRP14, a 14kD cytosolic protein that shows disulfide reductase activity in vitro with a different substrate specificity compared with another human cytosolic protein, TRX1. ...