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Mnt MAX network transcriptional repressor [ Rattus norvegicus (Norway rat) ]

Gene ID: 287521, updated on 2-Nov-2024

Summary

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Official Symbol
Mntprovided by RGD
Official Full Name
MAX network transcriptional repressorprovided by RGD
Primary source
RGD:1308683
See related
EnsemblRapid:ENSRNOG00000002894 AllianceGenome:RGD:1308683
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including cellular senescence; negative regulation of apoptotic signaling pathway; and regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Orthologous to human MNT (MAX network transcriptional repressor). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Thymus (RPKM 18.8), Spleen (RPKM 18.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mnt in Genome Data Viewer
Location:
10q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60197654..60213221)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (59699208..59714848)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (61683776..61700504)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene methyltransferase 16, RNA N6-adenosine Neighboring gene small G protein signaling modulator 2 Neighboring gene small nucleolar RNA SNORD91 family Neighboring gene TSR1, ribosome maturation factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury. Takayanagi T, et al. Atherosclerosis, 2013 May. PMID 23535568, Free PMC Article
  2. Mnt transcriptional repressor is functionally regulated during cell cycle progression. Popov N, et al. Oncogene, 2005 Dec 15. PMID 16103876
  3. Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor. Meroni G, et al. EMBO J, 1997 May 15. PMID 9184233, Free PMC Article
  4. Deletion of Mnt leads to disrupted cell cycle control and tumorigenesis. Hurlin PJ, et al. EMBO J, 2003 Sep 15. PMID 12970171, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These data identify Mnt as a previously unrecognized negative regulator of pathological vascular remodeling.
    Title: A repressor protein, Mnt, is a novel negative regulator of vascular smooth muscle cell hypertrophy by angiotensin II and neointimal hyperplasia by arterial injury.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular senescence ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
max-binding protein MNT
Names
MNT, MAX dimerization protein
max binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105807.2 → NP_001099277.2  max-binding protein MNT

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A0U1RRY7
    Related
    ENSRNOP00000075865.1, ENSRNOT00000092606.3
    Conserved Domains (1) summary
    cd11402
    Location:222 → 298
    bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60197654..60213221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085506.2 → XP_038941434.1  max-binding protein MNT isoform X1

    UniProtKB/TrEMBL
    D3ZF98
    Related
    ENSRNOP00000003933.5, ENSRNOT00000003933.7
    Conserved Domains (1) summary
    cd11402
    Location:221 → 284
    bHLHzip_Mnt; basic Helix-Loop-Helix-zipper (bHLHzip) domain found in Max-binding protein Mnt and similar proteins

  2. XM_039085507.2 → XP_038941435.1  max-binding protein MNT isoform X2

    Conserved Domains (1) summary
    cl00081
    Location:9 → 36
    bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

  3. XM_039085508.2 → XP_038941436.1  max-binding protein MNT isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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