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Slc43a2 solute carrier family 43 member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 287532, updated on 2-Nov-2024

Summary

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Official Symbol
Slc43a2provided by RGD
Official Full Name
solute carrier family 43 member 2provided by RGD
Primary source
RGD:1305819
See related
EnsemblRapid:ENSRNOG00000003835 AllianceGenome:RGD:1305819
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305819
Summary
Predicted to enable L-amino acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transport. Predicted to act upstream of or within L-alpha-amino acid transmembrane transport and negative regulation of L-leucine import across plasma membrane. Predicted to be located in basolateral plasma membrane. Orthologous to human SLC43A2 (solute carrier family 43 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in Kidney (RPKM 321.7), Brain (RPKM 108.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Slc43a2 in Genome Data Viewer
Location:
10q24
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (60873721..60919113)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (60375462..60420838)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (63676317..63719283)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene Rab interacting lysosomal protein Neighboring gene scavenger receptor class F, member 1 Neighboring gene phosphatidylinositol transfer protein, alpha Neighboring gene glutathione peroxidase 4, pseudogene 2 Neighboring gene inositol polyphosphate-5-phosphatase K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of LAT4, a novel amino acid transporter with system L activity. Bodoy S, et al. J Biol Chem, 2005 Mar 25. PMID 15659399
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-isoleucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-leucine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-methionine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-phenylalanine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables neutral L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within L-alpha-amino acid transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within L-amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in isoleucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in methionine transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of L-leucine import across plasma membrane ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
large neutral amino acids transporter small subunit 4
Names
solute carrier family 43 (amino acid system L transporter), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105812.1 → NP_001099282.1  large neutral amino acids transporter small subunit 4

    See identical proteins and their annotated locations for NP_001099282.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473948
    UniProtKB/TrEMBL
    A6HGS1, D3ZDC2
    Related
    ENSRNOP00000005100.4, ENSRNOT00000005100.6
    Conserved Domains (1) summary
    cl28910
    Location:90 → 239
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    60873721..60919113
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039085518.2 → XP_038941446.1  large neutral amino acids transporter small subunit 4 isoform X1

    UniProtKB/TrEMBL
    A6HGS1, D3ZDC2
    Conserved Domains (1) summary
    cl28910
    Location:90 → 239
    MFS; Major Facilitator Superfamily

  2. XM_063268680.1 → XP_063124750.1  large neutral amino acids transporter small subunit 4 isoform X1

    UniProtKB/TrEMBL
    A6HGS1, D3ZDC2

  3. XM_063268679.1 → XP_063124749.1  large neutral amino acids transporter small subunit 4 isoform X1

    UniProtKB/TrEMBL
    A6HGS1, D3ZDC2

  4. XM_063268681.1 → XP_063124751.1  large neutral amino acids transporter small subunit 4 isoform X2

    Related
    ENSRNOP00000105638.1, ENSRNOT00000132929.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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